methacrylic acid-(3-nitro-phenyl ester) | 16522-40-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: methacrylic acid-(3-nitro-phenyl ester)
• 英文别名: Methacrylsaeure-(3-nitro-phenylester)；(3-Nitrophenyl) 2-methylprop-2-enoate
• CAS: 16522-40-0
• 化学式: C₁₀H₉NO₄
• 分子量: 207.186
• InChiKey: UTISFCFKPMKVKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  间硝基苯酚 、 甲基丙烯酰氯 生成 methacrylic acid-(3-nitro-phenyl ester)
  参考文献：
  名称：

  核取代的甲基丙烯酸苯酯在与苯乙烯自由基共聚中的反应性

  摘要：

  为了阐明烷基取代基对甲基丙烯酸酯单体对自由基攻击的反应性的影响，研究了一系列核取代的甲基丙烯酸苯酯与苯乙烯的共聚反应。根据结果​​，确定了单体反应性比率和 Alfrey-Price Q 和 e 值。发现对聚苯乙烯基团的相对反应性与普通的哈米特方程无关，但通过包含取​​代基共振贡献项的修正哈米特方程获得了线性关系。因此，认为取代的甲基丙烯酸苯酯的反应性取决于由取代基引起的极性和共振效应。

  DOI：

  10.1246/bcsj.41.204

文献信息

• NOVEL PROPENOHYDROXAMIC ACID DERIVATIVES
  申请人：WAKUNAGA PHARMACEUTICAL CO., LTD.

  公开号：EP1314721A1

  公开（公告）日：2003-05-28

  Provided are a propenohydroxamic acid derivative represented by the following formula (1): [wherein, R1 represents a hydrogen atom, an alkyl group or a halogen atom, R2 represents a cycloalkyl group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group, R3 represents a hydrogen atom or a halogen atom, R4 represents a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted alkenyl group, R5 represents R6CO-, R6SO2-, R6NRCO- or R6NHCS- (in which, R6 represents a substituted or unsubstituted alkyl or cycloalkyl group, a cyclic amino group, a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group), R7 represents a hydrogen atom or a protecting group and A represents CH, a nitrogen atom or an oxidized nitrogen atom], or salt thereof; and a medicament containing the propenohydroxamic acid derivative or salt thereof. The compound (1) or salt thereof has excellent TACE inhibitory activity and is therefore useful as a medicament for preventing and/or treating diseases such as septicemia, rheumatoid arthritis, osteoarthritis, infectious diseases, autoimmune diseases, malignant neoplasm, collagenosis, chronic ulcerative colitis, MOF and insulin-independent diabetes.

  提供的是以下式（1）所表示的丙烯羟羟肟酸衍生物：[其中，R1代表氢原子、烷基或卤素原子，R2代表环烷基、取代或未取代芳基或取代或未取代杂环芳基，R3代表氢原子或卤素原子，R4代表氢原子、取代或未取代烷基或取代或未取代烯基，R5代表R6CO-、R6SO2-、R6NRCO-或R6NHCS-（其中，R6代表取代或未取代烷基或环烷基、环氨基、取代或未取代芳基或取代或未取代杂环芳基），R7代表氢原子或保护基，A代表CH、氮原子或氧化氮原子]，或其盐；以及含有该丙烯羟羟肟酸衍生物或其盐的药物。该化合物（1）或其盐具有优异的TACE抑制活性，因此可用作预防和/或治疗败血症、类风湿关节炎、骨关节炎、传染病、自身免疫疾病、恶性肿瘤、结缔组织病、慢性溃疡性结肠炎、多器官功能障碍综合征和胰岛素非依赖性糖尿病等疾病的药物。
• Ethylene polymers or copolymers having improved insulating properties, compositions, and power cables made therefrom
  申请人：NIPPON PETROCHEMICALS COMPANY, LIMITED

  公开号：EP0463402A2

  公开（公告）日：1992-01-02

  The invention provides a polar group-containing ethylene polymer or copolymer having improved insulating properties, or a composition thereof characterized in that said polar group-containing ethylene polymer or copolymer contains 20 to 8000 ppm of a polar group having a dipolemoment of more than 0.8 debye. Provided is furthermore a power cable having an insulating layer which comprises a polar group-containing ethylene polymer or copolymer containing 20 to

  本发明提供了一种具有更好绝缘性能的含极性基团的乙烯聚合物或共聚物，或其组合物，其特征在于所述含极性基团的乙烯聚合物或共聚物含有 20 至 8000 ppm 的极性基团，该极性基团的偶极矩大于 0.8 debye。本发明还提供了一种电力电缆，其绝缘层由含极性基团的乙烯聚合物或共聚物组成，该极性基团的偶极矩大于 0.8 德贝。
• Responsive microgel and methods related thereto
  申请人：——

  公开号：US20030152623A1

  公开（公告）日：2003-08-14

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.

  本发明提供了一种响应型微凝胶，该微凝胶可对选自由温度、pH 值和离子条件组成的组中的一种或多种水性条件的变化作出体积上和可逆的响应、和离子条件）组成的共价交联均聚可离子化单体的可离子化网络，其中可离子化网络与两性共聚物共价连接，形成多条 "悬链"，两性共聚物的 "悬链 "在水溶液中形成不动的胶束状聚集体。还提供了一种响应性微凝胶，它包含至少一种治疗实体，并能在生理条件下提供治疗实体的线性和持续释放。
• Lebedew; Andrianowa, Zhurnal Obshchei Khimii, 1955, vol. 25, p. 210,211, 212; engl. Ausg. S. 193
  作者：Lebedew、Andrianowa

  DOI：——

  日期：——
• Palladium catalysed reactions of allenes, carbon monoxide and nucleophiles
  作者：Ronald Grigg、Michael Monteith、Visuvanathar Sridharan、Catherine Terrier

  DOI：10.1016/s0040-4020(98)00115-x

  日期：1998.4

  Hydridopalladium(II) species generated in situ by oxidative addition of Pd(0) to acetic acid or acidic hydroxyl substrates (phenols, oximes) catalyse the termolecular assembly of allenes, CO and amines (primary, secondary) or oxygen nucleophiles to give methacrylamides or methacrylate esters and derivatives thereof in good to excellent yield. (C) 1998 Elsevier Science Ltd. All rights reserved.