1-[(6aR,8R,9R,9aS)-9-[(E)-3-(4-methyl-3,5-dioxo-1,2,4-triazolidin-1-yl)prop-1-enyl]-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione | 214264-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-[(6aR,8R,9R,9aS)-9-[(E)-3-(4-methyl-3,5-dioxo-1,2,4-triazolidin-1-yl)prop-1-enyl]-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione
• CAS: 214264-55-8
• 化学式: C₂₇H₄₅N₅O₈Si₂
• 分子量: 623.854
• InChiKey: LHJSCCSEHGMMOW-KEIPIJCRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.45
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  139
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-[(6aR,8R,9R,9aS)-9-[(E)-3-(4-methyl-3,5-dioxo-1,2,4-triazolidin-1-yl)prop-1-enyl]-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione 在 吡啶 、 sodium tetrahydroborate 、 臭氧 、 triethylamine tris(hydrogen fluoride) 作用下， 以 四氢呋喃 为溶剂， 反应 3.17h， 生成 2'-deoxy-2'-α-C-(acetoxymethyl)uridine
  参考文献：
  名称：

  The Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA

  摘要：

  Five 2'-C-functionalized nucleosides (1-5) have been prepared and incorporated into dinucleoside monophosphates. The effect of the functionality on the stability of the adjacent phosphodiester bond toward hydrolysis by nuclease enzymes and extremes of pH has been assessed.

  DOI：

  10.1080/07328319708006215
• 作为产物：
  描述：

  4-甲基-1,2,4-三吖啉-3,5-二酮 、 1-((2R,3R,3aS,9aR)-3-Allyl-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-4-hydroxy-1H-pyrimidin-2-one 以 二氯甲烷 为溶剂， 反应 16.0h， 以91%的产率得到1-[(6aR,8R,9R,9aS)-9-[(E)-3-(4-methyl-3,5-dioxo-1,2,4-triazolidin-1-yl)prop-1-enyl]-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione
  参考文献：
  名称：

  The synthesis of 2′-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer

  摘要：

  An efficient route to 2'-homouridine (1), a new nucleoside analogue, is reported that is based on an ene reaction. This nucleoside has been incorporated into a dinucleoside monophosphate and hydrolytic studies on the dimer show that it does not behave like a ribonucleotide. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01478-6

文献信息

• The synthesis of 2′-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer
  作者：John B.J. Pavey、Anthony J. Lawrence、Andrew J. Potter、Richard Cosstick、Ian A. O'Neil

  DOI：10.1016/s0040-4039(98)01478-6

  日期：1998.9

  An efficient route to 2'-homouridine (1), a new nucleoside analogue, is reported that is based on an ene reaction. This nucleoside has been incorporated into a dinucleoside monophosphate and hydrolytic studies on the dimer show that it does not behave like a ribonucleotide. (C) 1998 Elsevier Science Ltd. All rights reserved.
• The Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA
  作者：Anthony J. Lawrence、John B. J. Pavey、Ian A. O'Neil、Richard Cosstick

  DOI：10.1080/07328319708006215

  日期：1997.7

  Five 2'-C-functionalized nucleosides (1-5) have been prepared and incorporated into dinucleoside monophosphates. The effect of the functionality on the stability of the adjacent phosphodiester bond toward hydrolysis by nuclease enzymes and extremes of pH has been assessed.