Propanil | 25487-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Propanil
• 英文别名: propionic acid-(2,4-dichloro-anilide)；Propionsaeure-(2,4-dichlor-anilid)；N-(2,4-dichlorophenyl)propanamide
• CAS: 25487-78-9
• 化学式: C₉H₉Cl₂NO
• mdl: MFCD00507330
• 分子量: 218.083
• InChiKey: OZCNFDJEXXWEKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Propanil 在 sodium acetate 、 氯 、 溶剂黄146 作用下， 生成 propionic acid-(2,4,N-trichloro-anilide)
  参考文献：
  名称：

  Chattaway, Journal of the Chemical Society, 1902, vol. 81, p. 639,641

  摘要：

  DOI：
• 作为产物：
  描述：

  N-苯基丙酰胺 在 溶剂黄146 作用下， 生成 Propanil
  参考文献：
  名称：

  Chattaway, Journal of the Chemical Society, 1902, vol. 81, p. 639,641

  摘要：

  DOI：

文献信息

• [EN] ACLY INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS D'ACLY ET LEURS UTILISATIONS
  申请人：NIMBUS ARTEMIS INC

  公开号：WO2020097408A1

  公开（公告）日：2020-05-14

  The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.

  本发明提供了作为ATP柠檬酸裂合酶（ACLY）抑制剂的化合物、其组合物以及使用方法。
• IDO inhibitors
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US10167254B2

  公开（公告）日：2019-01-01

  There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.

  本发明公开了调节或抑制吲哚胺-2,3-二氧化酶（IDO）酶活性的化合物、含有上述化合物的药物组合物以及利用本发明化合物治疗增殖性疾病（如癌症、病毒感染和/或炎症性疾病）的方法。
• National Socialism and Literary Adaptation: Gustaf Gründgens’s Der Schritt vom Wege and Helmut Käutner’s Kleider Machen Leute
  作者：Paul Coates

  DOI：10.1111/1468-0483.00162

  日期：2000.4

  Eric Rentschler argues that ‘film production in the Third Reich offers a strikingly concrete example’ of the theoretical construct of ‘the dominant cinema’ (‘Hollywood’) devised by film theorists. But is the era of ‘Germany’s Hollywood’ ideological in the same way as Hollywood, or in a different way? Consideration of National Socialist adaptations of non‐Nazi texts may help one determine the specific meaning of the ideological in the Nazi context. The admittedly small area of National Socialist literary adaptation acquires a disproportionately revelatory potential due to the clearly perceptible disparities between the original, pre‐Nazi texts and their Nazi‐era reworkings. The adaptations considered here are Gustaf Gründgens’s Der Schritt vom Wege (1939), based on Fontane’s Effi Briest – a parti‐cularly problematic work for National Socialist ideology – and Helmut Käutner’s version of Gottfried Keller’s Kleider machen Leute (1940), whose admission of its own approximate relationship with the original narrative seems to dismiss the probably irresoluble problem of fidelity to the original, but which is also problematic.
• IDO INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20170231999A1

  公开（公告）日：2017-08-17

  There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
• ACLY INHIBITORS AND USES THEREOF
  申请人：Nimbus Artemis, Inc.

  公开号：US20200148634A1

  公开（公告）日：2020-05-14

  The present invention provides compounds useful as inhibitors of ATP citrate lyase (ACLY), compositions thereof, and methods of using the same.