N-Benzhydrylcarbaminsaeuremethylester | 14983-80-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Benzhydrylcarbaminsaeuremethylester
• 英文别名: methyl N-benzhydrylcarbamate
• CAS: 14983-80-3
• 化学式: C₁₅H₁₅NO₂
• mdl: MFCD03040342
• 分子量: 241.29
• InChiKey: CDSSYNXBUGMMSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.133
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  methyl 2-amino-2,2-diphenylacetate 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以73%的产率得到N-Benzhydrylcarbaminsaeuremethylester
  参考文献：
  名称：

  Synthesis of 3-tert-alkyl-2,4-imidazolidinediones

  摘要：

  DOI：

  10.1021/jo00202a021

文献信息

• An expedient, efficient and solvent-free synthesis of T3P®-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation
  作者：Srinivas Cheruku、Sandhya C. Nagarakere、Makanahalli P. Sunilkumar、Yatheesh Narayana、Kumara N. Manikyanally、Kanchugarakoppal S. Rangappa、Kempegowda Mantelingu

  DOI：10.1039/d1nj04502d

  日期：——

  An expedient, efficient, economical, environmentally benign, and solvent free amidation protocol of benzhydrols with less reactive nitrogen nucleophiles assisted by propylphosphonic anhydride (T3P®) under microwave irradiation has been developed. The methodology has been deployed for a wide range of heterocycles and electron-withdrawing & electron-donating groups. The protocol resulted in good to excellent

  已经开发了一种方便、高效、经济、环境友好且无溶剂的苯甲醇与低活性氮亲核试剂的酰胺化方案，该方案在微波辐射下由丙基膦酸酐 (T3P®) 辅助。该方法已应用于广泛的杂环和吸电子和给电子基团。该协议在给定条件下产生了良好的产量（26 个示例，68-93% 的产量）。
• Acat inhibitors
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0415413A1

  公开（公告）日：1991-03-06

  The present invention are novel amino acid amide compounds of the following general formula which inhibit the enzyme acylcoenzyme A:cholesterol acyltransferase: wherein R is phenyl or 1- or 2-naphthyl which are unsubstituted or may be substituted; R₁ is hydrogen or a straight or branched alkyl group having from 1 to 6 carbon atoms; R₂ is hydrogen, an aliphatic group, an aromatic group, an aralkyl or diarylalkyl group or R₁ and R₂ form a carbocyclic group; R₃ is hydrogen, an aliphatic group, an aralkyl group wherein the alkyl moiety may contain a carbocyclic entity; R₄ is hydrogen, an aliphatic group, SO₂R₁₄, -C(=S)NHR₁₅, -CO₂R₁₅, -COR₁₈, or -C(=O)NHR₁₅ wherein R₁₄ is morpholino, phenyl or substituted phenyl; R₁₅ is an alkyl group, phenyl or phenylalkyl wherein the phenyl group may be substituted; and R₁₈ is the same is R₁₅ or is halo-substituted alkyl, 9-fluorenylmethylene or pyrrolidino.

  本发明是通式如下的新型氨基酸酰胺化合物，可抑制酰辅酶 A：胆固醇酰基转移酶： 其中 R 是苯基或 1-或 2-萘基，它们未被取代或可能被取代；R₁ 是氢或具有 1 至 6 个碳原子的直链或支链烷基；R₂ 是氢、脂肪族基团、芳香族基团、芳烷基或二芳基烷基，或 R₁ 和 R₂ 形成碳环基团； R₃ 是氢、脂肪族基团、芳烷基基团，其中烷基可包含碳环实体；R₄ 是氢、脂肪族基团、SO₂R₁₄、-C(=S)NHR₁₅、-COR₂R₁₅、-COR₁₈ 或 -C(=O)NHR₁₅，其中 R₁₄ 是吗啉基、苯基或取代苯基；R₁₅ 是烷基、苯基或苯基烷基，其中苯基可被取代；以及 R₁₈ 与 R₁₅ 相同，或者是卤代烷基、9-芴基亚甲基或吡咯烷基。
• Process for producing isocyanates
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0672653A1

  公开（公告）日：1995-09-20

  Provided is a process for producing isocyanates from carbamic acid esters which comprises thermally decomposing carbamic acid esters in the presence of a catalyst containing at least one compound selected from the group consisting of organic sulfonic acids and alkaline metal salts of organic sulfonic acids. Thereby, a high thermal decomposition rate can be provided and isocyanate can be obtained in a high yield.

  本发明提供了一种从氨基甲酸酯生产异氰酸酯的工艺，该工艺包括在含有至少一种从有机磺酸和有机磺酸的碱金属盐组成的组中选出的化合物的催化剂存在下对氨基甲酸酯进行热分解。 因此，热分解率高，异氰酸酯的收率也高。
• METHOD FOR TREATMENT OF ISOCYANATE RESIDUE, AND METHOD FOR TREATMENT OF CARBONATE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2518044A1

  公开（公告）日：2012-10-31

  A method for treating an isocyanate residue, which comprises carrying out a thermal decomposition reaction of a carbamate that is produced by the reaction among an amine, urea and/or an N-unsubstituted carbamic acid ester and an alcohol to produce a decomposition solution, separating an isocyanate and the alcohol from the decomposition solution to produce the isocyanate residue, and bringing the isocyanate residue into contact with high-pressure/high-temperature water to decompose the isocyanate residue into an amine; and a method for treating a carbonate, which comprises bringing the carbonate into contact with high-pressure/high-temperature water to decompose the carbonate into an alcohol.

  一种处理异氰酸酯残留物的方法，包括对氨基甲酸酯进行热分解反应，该氨基甲酸酯是由胺、尿素和/或 N-未取代氨基甲酸酯与醇反应生成的，从分解溶液中分离出异氰酸酯和醇，生成异氰酸酯残留物，将异氰酸酯残留物与高压/高温水接触，将异氰酸酯残留物分解成胺；一种处理碳酸盐的方法，包括使碳酸盐与高压/高温水接触，将碳酸盐分解成醇。
• Rhodium-catalyzed arylation of α-amido sulfones with arylboronic acids in a water–toluene biphasic system
  作者：Xiao-Yong Dou、Qi Shuai、Liang-Nian He、Chao-Jun Li

  DOI：10.1016/j.ica.2010.09.056

  日期：2011.4

  An efficient method for the synthesis of N-protected diaryl-methyl-amines was developed through a rhodium-catalyzed arylation of alpha-amido sulfones with arylboronic acids in a water-toluene biphasic system. The use of a base combined with a surfactant played a key role in this biphasic reaction. A diverse range of alpha-branched amine derivatives bearing different functional groups were obtained within 10 min under the present conditions. (C) 2010 Elsevier B. V. All rights reserved.