Methyl 2-(1-methoxy-1,3-dioxobutan-2-yl)pyrrolidine-1-carboxylate | 76460-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Methyl 2-(1-methoxy-1,3-dioxobutan-2-yl)pyrrolidine-1-carboxylate
• CAS: 76460-89-4
• 化学式: C₁₁H₁₇NO₅
• 分子量: 243.26
• InChiKey: XZWJUCBPOMXUMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  331.6±12.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吡咯烷甲基氨基甲酸酯 在 三氟甲磺酸 作用下， 反应 12.0h， 生成 Methyl 2-(1-methoxy-1,3-dioxobutan-2-yl)pyrrolidine-1-carboxylate
  参考文献：
  名称：

  The Mannich-type Reaction between N,O-Acetals and Carbon Nucleophiles under Solvent-free Conditions

  摘要：

  The Mannich-type reaction for 1-methoxycarbonyl- or 1-benzyloxycarbonyl-2-methoxylpyrrolidine with carbon nucleophiles such as acetylacetone, methyl acetoacetate, dimethyl malonates, benzoylacetone, dibenzoylmethane, or cyclohexane-1, 3-dione proceeded by acid catalysis under solvent-free conditions with more efficiency than that in dichloromethane.

  DOI：

  10.3987/com-05-s(t)34

文献信息

• Electroorganic chemistry. 46. A new carbon-carbon bond forming reaction at the .alpha.-position of amines utilizing anodic oxidation as a key step
  作者：Tatsuya Shono、Yoshihiro Matsumura、Kenji Tsubata

  DOI：10.1021/ja00395a029

  日期：1981.3
• The Mannich-type Reaction between N,O-Acetals and Carbon Nucleophiles under Solvent-free Conditions
  作者：Yoshihiro Matsumura、Takashi Ikeda、Osamu Onomura

  DOI：10.3987/com-05-s(t)34

  日期：——

  The Mannich-type reaction for 1-methoxycarbonyl- or 1-benzyloxycarbonyl-2-methoxylpyrrolidine with carbon nucleophiles such as acetylacetone, methyl acetoacetate, dimethyl malonates, benzoylacetone, dibenzoylmethane, or cyclohexane-1, 3-dione proceeded by acid catalysis under solvent-free conditions with more efficiency than that in dichloromethane.