S-(8-hydroxyoctyl) thioacetate | 176753-25-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 硫代羧酸及其衍生物
• 英文名称: S-(8-hydroxyoctyl) thioacetate
• 英文别名: 8-acetylthio-1-octanol；S-(8-hydroxyoctyl) ethanethioate
• CAS: 176753-25-6
• 化学式: C₁₀H₂₀O₂S
• 分子量: 204.334
• InChiKey: FVAQUEDCAQLDKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  S-(8-hydroxyoctyl) thioacetate 在 盐酸 、 甲醇 作用下， 以100%的产率得到8-巯基-1-辛醇
  参考文献：
  名称：

  金上链烷硫醇官能化自组装单层的分子识别

  摘要：

  描述了使用荧光受体探测有机界面上的分子识别事件的系统。由间苯二甲酸的双 (2,6-二氨基吡啶) 酰胺形成的受体被纳入金上链烷硫醇的混合自组装单层 (SAM) 中，并显示出与溶液中的巴比妥酸衍生物相互作用。已经检查了影响表面受体从溶液中识别配体的能力的各个参数以及配体溶液的各种溶剂。

  DOI：

  10.1021/ja973166h
• 作为产物：
  描述：

  8-溴-1-辛醇 、 硫代乙酸 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 13.5h， 以71%的产率得到S-(8-hydroxyoctyl) thioacetate
  参考文献：
  名称：

  Redox-active self-assembled monolayers as novel solid contacts for ion-selective electrodes

  摘要：

  一种新的方法论，通过使用亲脂性红氧化活性化合物的自组装单层(SAMs)来制造固体接触离子选择电极(SC-ISEs)，以促进界面上的电荷转移，从而提高了电位稳定性，并防止了基于伏拉霉素的SC-ISEs受到氧化还原或O2的干扰。

  DOI：

  10.1039/a909532b

文献信息

• NEPHROTROPIC DRUGS
  申请人：Drug Delivery System Institute, Ltd.

  公开号：EP0953357A1

  公开（公告）日：1999-11-03

  Disclosed are a drug having renal selectivity and a drug carrier for specifically transporting a drug supported thereon to a kidney. A segment structure specifically recognizable in the kidney is utilized. More specifically, since a segment structure represented by formula (I) is kidney-oriented, introduction of a drug into a molecule having the segment structure can provide a renal targeting drug. A compound, which has the segment structure and can support a drug thereon, can be utilized as a drug carrier which can specifically transport a drug supported thereon to the kidney.         A-U-V-     (I) wherein A represents glycosyl, such as glucosyl, mannosyl, or 2-deoxy-glucosyl; U represents O, S, or NH; and V represents an aromatic hydrocarbon or a straight-chain or branched C1-18 aliphatic hydrocarbon.

  本发明涉及一种具有肾脏选择性的药物和一种药物载体，用于将支持在其上的药物专门运输到肾脏。利用在肾脏中特别可识别的片段结构。更具体地说，由式（I）表示的片段结构是以肾脏为导向的，将药物引入具有该片段结构的分子中可以提供肾脏靶向药物。具有该片段结构并能支持药物的化合物可用作药物载体，可将支持在其上的药物专门运输到肾脏。其中，A代表糖基，如葡萄糖基、甘露糖基或2-脱氧葡萄糖基；U代表O、S或NH；V代表芳香族碳氢化合物或直链或支链C1-18脂肪族碳氢化合物。
• Synthesis of (3<i>E</i>)-Dodecen-12-olide, a Potential Pheromone Component of the Emerald Ash Borer
  作者：D. I. MaGee、P. D. Mayo、P. J. Silk、B. Beattie

  DOI：10.1080/00397911.2011.634083

  日期：2013.5.15

  Emerald ash borer (EAB), Agrilus planipennis Fairmaire, is an invasive insect that has killed millions of ash trees in the USA and Canada. A concise synthesis of a potential EAB pheromone component, (3E)-dodecen-12-olide, using highly stereoselective JuliaKocienski olefination as the key step, is reported. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.
• Synthesis and antifungal activity of alkylthio and alkylsulfonyl derivatives of SM-8668
  作者：Hiroshi Miyauchi、Koichi Kozuki、Tomoharu Tanio、Naohito Ohashi

  DOI：10.1016/0968-0896(95)00180-8

  日期：1996.2

  Triazole analogues which contained alkylthio or alkylsulfonyl groups where synthesized as derivatives of antifungal SM-8668 and estimated for their in vitro and in vivo activity. Derivatives having pentylthio, heptylthio or nonylthio groups showed excellent efficacy against both candidiasis and aspergillosis. Introduction of a hydrophilic group at the end of their alkyl chain made their activity stronger. Especially, 5-hydroxypentylthio and 7-hydroxyheptylthio derivatives showed the strongest antifungal activity.
• Molecular Recognition on Functionalized Self-Assembled Monolayers of Alkanethiols on Gold
  作者：Kianoush Motesharei、David C. Myles

  DOI：10.1021/ja973166h

  日期：1998.7.1

  A system for probing molecular recognition events at organic interfaces using fluorescent receptors is described. Receptors formed from the bis(2,6-diaminopyridine) amide of isophthalic acid are incorporated in mixed self-assembled monolayers (SAMs) of alkanethiols on gold and shown to interact with barbituric acid derivatives from solution. Individual parameters that affect the ability of receptors

  描述了使用荧光受体探测有机界面上的分子识别事件的系统。由间苯二甲酸的双 (2,6-二氨基吡啶) 酰胺形成的受体被纳入金上链烷硫醇的混合自组装单层 (SAM) 中，并显示出与溶液中的巴比妥酸衍生物相互作用。已经检查了影响表面受体从溶液中识别配体的能力的各个参数以及配体溶液的各种溶剂。
• Redox-active self-assembled monolayers as novel solid contacts for ion-selective electrodes
  作者：Monia Fibbioli、Olivier Enger、François Diederich、Ernö Pretsch、Krisanu Bandyopadhyay、Sheng-Gao Liu、Luis Echegoyen、Philippe Bühlmann

  DOI：10.1039/a909532b

  日期：——

  A new methodology to fabricate solid-contact ion-selective electrodes (SC-ISEs) using SAMs of a lipophilic redox-active compound to facilitate the charge transfer across the interface leads to improved potential stability and prevents redox or O2 interference of valinomycin-based SC-ISEs.

  一种新的方法论，通过使用亲脂性红氧化活性化合物的自组装单层(SAMs)来制造固体接触离子选择电极(SC-ISEs)，以促进界面上的电荷转移，从而提高了电位稳定性，并防止了基于伏拉霉素的SC-ISEs受到氧化还原或O2的干扰。