1,8-dimorpholino-octane | 79089-27-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1,8-dimorpholino-octane
• 英文别名: 1,8-Dimorpholino-octan；4-(8-Morpholin-4-yloctyl)morpholine
• CAS: 79089-27-3
• 化学式: C₁₆H₃₂N₂O₂
• 分子量: 284.442
• InChiKey: AYSJVPMRGPIBOI-UHFFFAOYSA-N

物化性质

• 沸点：
  391.3±37.0 °C(Predicted)
• 密度：
  0.981±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吗啉 、 1,8-辛二醇 在 Pt-Sn/γ-Al2O3 作用下， 以 邻二甲苯 为溶剂， 反应 24.0h， 以84%的产率得到1,8-dimorpholino-octane
  参考文献：
  名称：

  Heterogeneous bimetallic Pt–Sn/γ-Al2O3 catalyzed direct synthesis of diamines from N-alkylation of amines with diols through a borrowing hydrogen strategy

  摘要：

  Direct synthesis of diamines has been efficiently realized from the N-alkylation of amines with diols by means of heterogeneous bimetallic Pt-Sn/gamma-Al2O3 catalyst (0.5 wt % Pt, molar ratio Pt:Sn = 1:3) through a 'Borrowing Hydrogen' strategy under ligand-free conditions. The present methodology provides an environmentally benign route to diamines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.10.100

文献信息

• One-Pot Synthesis of Tertiary α,ω-Diamines via Carbonylative Bis[hydroaminomethylation] of α,ω-Diolefins Using Di(μ-chloro)bis(η4-1,5-cyclooctadine)dirhodium as a Catalyst Precursor
  作者：Christian L. Kranemann、Peter Eilbracht

  DOI：10.1055/s-1998-4481

  日期：1998.1

  Tertiary α,ω-diamines are selectively prepared in high yields by the reaction of α,ω-diolefins with secondary amines, carbon monoxide and hydrogen in the presence of [Rh(cod)Cl]2 as a catalyst precursor. This one-pot synthesis proceeds via a hydroformylation-amine condensation-reduction sequence and leads to a mixture of n,n-, n,iso-, and iso,iso-products.

  通过α,ω-二烯与二级胺、一氧化碳和氢气在[Rh(cod)Cl]2作为催化前体的存在下反应，可选择性地高产率制备三级α,ω-二胺。这种一步合成法经过羰基化-胺缩合-还原的连续步骤，生成n,n-、n,异-和异,异-产品的混合物。
• alpha, omega-Amino Alcohols. I. N-Phenyl-N′-(ω-hydroxyalkyl)-piperazines from α,ω-Chlorohydrins. Derivatives of Piperazine. XVII
  作者：George W. Anderson、C. B. Pollard

  DOI：10.1021/ja01267a062

  日期：1939.12
• US5120731A
  申请人：——

  公开号：US5120731A

  公开（公告）日：1992-06-09
• Heterogeneous bimetallic Pt–Sn/γ-Al2O3 catalyzed direct synthesis of diamines from N-alkylation of amines with diols through a borrowing hydrogen strategy
  作者：Liandi Wang、Wei He、Kaikai Wu、Songbo He、Chenglin Sun、Zhengkun Yu

  DOI：10.1016/j.tetlet.2011.10.100

  日期：2011.12

  Direct synthesis of diamines has been efficiently realized from the N-alkylation of amines with diols by means of heterogeneous bimetallic Pt-Sn/gamma-Al2O3 catalyst (0.5 wt % Pt, molar ratio Pt:Sn = 1:3) through a 'Borrowing Hydrogen' strategy under ligand-free conditions. The present methodology provides an environmentally benign route to diamines. (C) 2011 Elsevier Ltd. All rights reserved.