piperazin-1-yl(4-propylphenyl)methanone | 1146119-42-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: piperazin-1-yl(4-propylphenyl)methanone
• 英文别名: 1-(4-Propylbenzoyl)piperazine；piperazin-1-yl-(4-propylphenyl)methanone
• CAS: 1146119-42-7
• 化学式: C₁₄H₂₀N₂O
• 分子量: 232.326
• InChiKey: GPAHJZIJPCELJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  piperazin-1-yl(4-propylphenyl)methanone 、 3-[4-(2-Amino-6-chloro-pyrimidin-4-yloxy)-phenyl]-2-methyl-2-phenoxy-propionic acid ethyl ester 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Discovery of novel dual functional agent as PPARγ agonist and 11β-HSD1 inhibitor for the treatment of diabetes

  摘要：

  PPAR gamma and 11 beta-HSD1 are attractive therapeutic targets for type 2 diabetes. However, PPAR gamma agonists induce adipogenesis, which causes the side effect of weight gain, whereas 11 beta-HSD1 inhibitors prevent adipogenesis and may be beneficial for the treatment of obesity in diabetic patients. For the first time, we designed, synthesized a series of alpha-aryloxy-alpha-methylhydrocinnamic acids as dual functional agents which activate PPAR gamma and inhibit 11 beta-HSD1 simultaneously. The compound 11e exhibited the most potent inhibitory activity compared to that of the lead compound 2, with PPAR gamma (EC50 = 6.76 mu M) and 11 beta-HSD1 (IC50 = 0.76 mu M) in vitro. Molecular modeling study for compound 11e was also presented. Compound 11e showed excellent efficacy for lowering glucose, triglycerides, body fat, in well established mice and rats models of diabetes and obesity and had a favorable ADME profile. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.082

文献信息

• VERWENDUNG SUBSTITUIERTER PYRIMIDINDIONE ODER JEWEILS DEREN SALZE ALS WIRKSTOFFE GEGEN ABIOTISCHEN PFLANZENSTRESS
  申请人：Bayer CropScience AG

  公开号：EP3332645A1

  公开（公告）日：2018-06-13

  Die Erfindung betrifft die Verwendung substituierter Pyrimidindione der Formel (I) oder deren Salze wobei die Reste in der allgemeinen Formel (I) den in der Beschreibung gegebenen Definitionen entsprechen, zur Erhöhung der Stresstoleranz in Pflanzen gegenüber abiotischem Stress und/oder zur Erhöhung des Pflanzenertrags.

  本发明涉及式 (I) 取代的嘧啶二酮或其盐类的用途 其中通式（I）中的基团与描述中给出的定义相对应、 用于提高植物对非生物胁迫的耐受性和/或增加植物产量。