(Z)-7-[(1S,2R,3S,4R)-3-[(E)-3-hydroxy-4-phenylpent-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid | 87983-63-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-7-[(1S,2R,3S,4R)-3-[(E)-3-hydroxy-4-phenylpent-1-enyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
• CAS: 87983-63-9
• 化学式: C₂₄H₃₂O₄
• 分子量: 384.5
• InChiKey: VGRCPALIWBYEPM-ANBWURGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Use of a thromboxane A2 receptor antagonist for the manufacture of a medicament for the treatment of ulcerative gastrointestinal conditions
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0448274A2

  公开（公告）日：1991-09-25

  A method is provided for protecting against and/or treating ulcerative gastrointestinal conditions, including anti-inflammatory drug-induced gastrointestinal ulcers, using a thromboxane A₂ receptor antagonist. In addition, a combination is provided which includes a thromboxane A₂ receptor antagonist and an anti-inflammatory agent which combination may be used to treat inflammatory conditions, such as arthritis, while inhibiting formation of and/or treating gastrointestinal ulcers.

  本发明提供了一种使用血栓素 A₂受体拮抗剂防止和/或治疗胃肠道溃疡病的方法，包括抗炎药物诱发的胃肠道溃疡。此外，还提供了一种组合物，其中包括血栓素 A₂受体拮抗剂和一种消炎药，该组合物可用于治疗关节炎等炎症，同时抑制胃肠道溃疡的形成和/或治疗胃肠道溃疡。
• TXA2 inhibitor as stimulator or inducer of MHC Class I cross-presentation
  申请人：INSTITUT PASTEUR

  公开号：EP3037106A1

  公开（公告）日：2016-06-29

  The application relates to a thromboxane A2 (TXA2) inhibitor. The application also relates to an Antigen Presenting Cell (APC), in the cytosol of which said TXA2 inhibitor is contained. Said TXA2 inhibitor can e.g., be a Non-Steroidal Anti-Inflammatory Drug (NSAID). More particularly, the application relates to means, such as preparations, compositions, and methods, which comprise or involve said TXA2 inhibitor or APC. Said TXA2 inhibitor or APC can notably be used as stimulator or inducer of the immune response, more particularly of MHC Class I cross-presentation.

  本申请涉及一种血栓素 A2（TXA2）抑制剂。本申请还涉及一种抗原呈递细胞（APC），其细胞液中含有所述 TXA2 抑制剂。所述 TXA2 抑制剂可以是非类固醇消炎药 (NSAID)。 更具体地说，本申请涉及包含或涉及所述 TXA2 抑制剂或 APC 的手段，如制剂、组合物和方法。 所述TXA2抑制剂或APC可显著用作免疫反应的刺激剂或诱导剂，尤其是MHC I类交叉呈递的刺激剂或诱导剂。
• US5312818A
  申请人：——

  公开号：US5312818A

  公开（公告）日：1994-05-17
• US5462726A
  申请人：——

  公开号：US5462726A

  公开（公告）日：1995-10-31