4-benzamido-1H-pyrazolo<3,4-d>pyrimidine | 82436-66-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-benzamido-1H-pyrazolo<3,4-d>pyrimidine
• 英文别名: 4-benzoylaminopyrazolo[3,4-d]pyrimidine；N⁶-benzoylamino-8-aza-7-deazaadenine；4-Benzamido-pyrazolo<3,4-d>pyrimidin；N-(1(2)H-pyrazolo[3,4-d]pyrimidin-4-yl)-benzamide；4-Benzamidopyrazolo(3,4-d)pyrimidine；N-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)benzamide
• CAS: 82436-66-6
• 化学式: C₁₂H₉N₅O
• 分子量: 239.236
• InChiKey: DNLQEUXYAPEVQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-benzamido-1H-pyrazolo<3,4-d>pyrimidine 在 四氧化锇 、 四(三苯基膦)钯 、 水 、 sodium hydride 、 N-甲基吗啉氧化物 、 三苯基膦 作用下， 以 四氢呋喃 、 二甲基亚砜 为溶剂， 反应 53.0h， 生成 9-[(1'R,2'S,3'R,4'S)-2',3',4'-trihydroxycyclopentan-1'-yl]-9-H-N⁶-benzoylamino-8-aza-7-deazapurine
  参考文献：
  名称：

  Synthesis of base-modified noraristeromycin derivatives and their inhibitory activity against human and Plasmodium falciparum recombinant S-adenosyl-l-homocysteine hydrolase

  摘要：

  Noraristeromycin derivatives possessing 2- or 8-position modified adenine or 8-aza-7-deazaadenine were synthesized, and their inhibitory activity against human and Plasmodium falciparum (P. falciparum) recombinant SAH hydrolases was investigated. Among these noraristeromycin derivatives, 2-aminonoraristeromycin selectively showed inhibitory activity against P. falciparum recombinant SAH hydrolase. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)01247-9

文献信息

• Photocatalytic C−H Azolation of Arenes Using Heterogeneous Carbon Nitride in Batch and Flow
  作者：Zhenghui Wen、Ting Wan、Arjun Vijeta、Carla Casadevall、Laura Buglioni、Erwin Reisner、Timothy Noël

  DOI：10.1002/cssc.202101767

  日期：2021.12.6

  Green and versatile! The photocatalytic C(sp2)−H azolation of arenes using heterogeneous carbon nitride is reported. This strategy exhibits a broad substrate scope and is amenable to the late-stage functionalization of several pharmaceuticals. The catalyst can be easily recovered and reused leading to greener and more sustainable routes.

  绿色环保，用途广泛！报道了使用非均相氮化碳对芳烃进行光催化 C(sp 2 )−H 偶氮化。该策略表现出广泛的底物范围，并且适合多种药物的后期功能化。该催化剂可以轻松回收和重复使用，从而形成更环保、更可持续的路线。
• Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 2. Synthesis and activity of some nucleosides of 4-(alkylamino)-1H-pyrazolo[3,4-d]pyrimidines
  作者：Janet L. Rideout、Thomas A. Krenitsky、George W. Koszalka、Naomi K. Cohn、Esther Y. Chao、Gertrude B. Elion、Victoria S. Latter、Raymond B. Williams

  DOI：10.1021/jm00351a007

  日期：1982.9

  A series of 4-(alkylamino)-1-beta-D-ribofuranosyl-1H-pyrazolo[3, 4-d]pyrimidines was synthesized by enzymatic and chemical methods. On the basis of the previous finding that 4-(alkylthio)-1-beta-D-ribofuranosyl-1H-pyrazolo[3,4-d]pyrimidines were effective anticoccidial agents, this series was examined for efficacy against Eimera tenella in chicks. The most active anticoccidial agent in the present

  通过酶和化学方法合成了一系列的4-（烷基氨基）-1-β-D-呋喃呋喃糖基-1H-吡唑并[3,4-d]嘧啶。基于先前的发现，即4-（烷硫基）-1-β-D-呋喃呋喃糖基-1H-吡唑并[3,4-d]嘧啶是有效的抗球虫药，我们对该系列的鸡抗艾美拉虫进行了研究。在本研究中，活性最高的抗球虫药是4-环戊基氨基衍生物（8），该化合物能清除雏鸡饮食中200 ppm的寄生虫。该系列的某些成员在体外对胚胎鸡肝细胞，小鼠细胞和人细胞有毒性。4-二乙氨基衍生物（16）在体外无毒，似乎对雏鸡有毒。
• Inflammatory mediator antagonists
  申请人：GLAXO GROUP LIMITED

  公开号：EP1849478A2

  公开（公告）日：2007-10-31

  The present invention relates to the use of antagonists of Oncostatin M (OSM) such as an antibody or small molecule for the treatment or prophylaxis of an inflammatory arthropathy or other inflammatory disorder, and the use of OSM to screen for such antagonists.

  本发明涉及 Oncostatin M（OSM）拮抗剂（如抗体或小分子）在治疗或预防炎症性关节病或其他炎症性疾病方面的用途，以及使用 OSM 来筛选此类拮抗剂。
• Oncostatin M (OSM) antagonists for preventing cancer metastasis and IL-6 related disorders
  申请人：Jorcyk Cheryl

  公开号：US10286070B2

  公开（公告）日：2019-05-14

  A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, proliferation and metastasis in several cancer types.

  提供了一种治疗癌症或转移瘤的方法，该方法涉及对受试者施用至少一种Oncostatin M（OSM）拮抗剂，其中受试者已被诊断患有癌症。提供了一种 OSM 拮抗剂（如小分子药物）以及一种抗 OSM 抗体、一种抗 OSM 合酶和一种 OSM mRNA 拮抗剂。研究发现，OSM拮抗剂可抑制或防止几种癌症类型的肿瘤细胞脱落、增殖和转移。
• ANTAGONISTS OF THE INFLAMMATORY MEDIATOR ONCOSTATIN M (OSM)
  申请人：GLAXO GROUP LIMITED

  公开号：EP1071449A2

  公开（公告）日：2001-01-31

表征谱图