(chloroacetyl)diphenylphosphane | 67991-19-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (chloroacetyl)diphenylphosphane
• 英文别名: (Cloracetyl)diphenylphosphan；2-Chloro-1-diphenylphosphanylethanone
• CAS: 67991-19-9
• 化学式: C₁₄H₁₂ClOP
• 分子量: 262.675
• InChiKey: JREATSCAPIRNSI-UHFFFAOYSA-N

物化性质

• 沸点：
  372.1±44.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (chloroacetyl)diphenylphosphane 在 magnesium 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 生成 2,2,2,2-tetracarbonyl-1,1-diphenyl-1-phospha-2-manganacyclobutan-4-one
  参考文献：
  名称：

  Lindner, Ekkehard; Merkle, Ralf Dieter; Hiller, Wolfgang, Chemische Berichte, 1986, vol. 119, # 2, p. 659 - 668

  摘要：

  DOI：
• 作为产物：
  描述：

  氯乙酰氯 、 二苯基(三甲基硅基)膦 以 二氯甲烷 为溶剂， 反应 0.33h， 生成 (chloroacetyl)diphenylphosphane
  参考文献：
  名称：

  Asymmetric Synthesis of α-Chiral Hydroxyalkylphosphines by a Catalytic Enantioselective Reduction of Acylphosphines

  摘要：

  Enantioselective reduction of acylphosphines, after precomplexation with borane, proceeded smoothly in the presence of a chiral oxazaborolidine catalyst and catecholborane. alpha-Hydroxyalkylphosphine products were obtained as phosphineborane complexes in good yield and enantioselectivity. One of the products of the enantioselective reduction was successfully applied as an optically active phosphine ligand for asymmetric catalysis after suitable derivatization.

  DOI：

  10.1021/ol5024757

文献信息

• Lindner, Ekkehard; Steinwand, Michael; Hoehne, Sigurd, Chemische Berichte, 1982, vol. 115, # 6, p. 2181 - 2191
  作者：Lindner, Ekkehard、Steinwand, Michael、Hoehne, Sigurd

  DOI：——

  日期：——
• Lindner, Ekkehard; Merkle, Ralf Dieter; Hiller, Wolfgang, Chemische Berichte, 1986, vol. 119, # 2, p. 659 - 668
  作者：Lindner, Ekkehard、Merkle, Ralf Dieter、Hiller, Wolfgang、Fawzi, Riad

  DOI：——

  日期：——
• Asymmetric Synthesis of α-Chiral Hydroxyalkylphosphines by a Catalytic Enantioselective Reduction of Acylphosphines
  作者：Minoru Hayashi、Hiroyuki Ishitobi、Yutaka Matsuura、Takashi Matsuura、Yutaka Watanabe

  DOI：10.1021/ol5024757

  日期：2014.11.21

  Enantioselective reduction of acylphosphines, after precomplexation with borane, proceeded smoothly in the presence of a chiral oxazaborolidine catalyst and catecholborane. alpha-Hydroxyalkylphosphine products were obtained as phosphineborane complexes in good yield and enantioselectivity. One of the products of the enantioselective reduction was successfully applied as an optically active phosphine ligand for asymmetric catalysis after suitable derivatization.