5,10,15,20-Tetra(2-hydroxyphenyl)porphyrin | 25186-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 5,10,15,20-Tetra(2-hydroxyphenyl)porphyrin
• 英文别名: 2-[10,15,20-tris(2-hydroxyphenyl)-21,23-dihydroporphyrin-5-yl]phenol
• CAS: 25186-28-1
• 化学式: C₄₄H₃₀N₄O₄
• 分子量: 678.7
• InChiKey: RHBJMYOTXIENOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  52
• 可旋转键数：
  4
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  138
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  吡咯 、 水杨醛 以 丙酸 为溶剂， 反应 24.5h， 以to yield 5,10,15,20-tetrakis(2′-hydroxyphenyl) porphyrin的产率得到5,10,15,20-Tetra(2-hydroxyphenyl)porphyrin
  参考文献：
  名称：

  Main-group metal-based asymmetric catalysts and applications thereof

  摘要：

  本发明涉及一种对底物的反应性π键进行立体选择性核苷酸加成的方法和催化剂。本发明的手性、非外消旋催化剂是首个包含主族金属和三或四配位配体的催化剂，用于核苷酸加成反应。

  公开号：

  US06844448B2

文献信息

• Asymmetric cycloaddition reactions
  申请人：——

  公开号：US20020004602A1

  公开（公告）日：2002-01-10

  The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of substrates, each either chiral or prochiral, that contain reactive &pgr;-systems, in the presence of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product. The present invention also relates to novel asymmetric catalyst complexes comprising a metal and an asymmetric tridentate ligand.

  本发明涉及一种立体选择性环加成反应的过程，通常包括在非外消旋手性催化剂的存在下，在含有反应性π-系统的手性或前手性的一对底物之间进行环加成反应，以产生立体异构体富集的产物。本发明还涉及一种新型的不对称催化剂配合物，包括金属和不对称三齿配体。
• Hydrolytic kinetic resolution of cyclic substrates
  申请人：——

  公开号：US20020032338A1

  公开（公告）日：2002-03-14

  The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.

  本发明涉及一种立体选择性或区域选择性化学合成的方法，通常包括在非外消旋手性催化剂的存在下，将亲核试剂和手性或前手性环状底物反应，以产生立体异构体和/或区域异构体富集的产物。本发明还涉及外消旋环氧化物的混合物的水解动力学分离。
• Stereoselective ring opening reactions
  申请人：President and Fellows of Harvard College

  公开号：US05665890A1

  公开（公告）日：1997-09-09

  The present invention relates a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catalyst to produce a steroisomerically or regioselectively enriched product.

  本发明涉及一种立体或区域选择性化学合成的方法，通常包括在非外消旋手性催化剂的存在下，将亲核试剂和手性或原手性环状底物反应，以产生立体异构体或区域选择性富集的产物。
• Nucleophilic kinetic resolution of cyclic substrates using silyl azides
  申请人：——

  公开号：US20040044233A1

  公开（公告）日：2004-03-04

  The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.

  本发明涉及一种立体选择性或区域选择性化学合成的过程，通常包括在非外消旋、手性催化剂的存在下，将亲核试剂和手性或前手性环状底物反应，以产生立体异构体和/或区域异构体富集的产物。本发明还涉及外消旋和二对映异构体环氧化物的水解动力学分辨。
• Main-group metal based asymmetric catalysts and applications thereof
  申请人：President and Fellows of Harvard College

  公开号：US06521561B1

  公开（公告）日：2003-02-18

  The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive &pgr;-bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.

  本发明涉及一种对底物的反应性π键进行立体选择性核受体加成的方法和催化剂。本发明的手性、非外消旋催化剂是首个包括主族金属和三-或四-配位配体的用于亲核加成的催化剂的例子。