3-Hydroxybutyl butyrate | 89457-26-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Hydroxybutyl butyrate
• 英文别名: 3-Hydroxybutyl butanoate
• CAS: 89457-26-1
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: YSZQEASOSAOOHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,3-dibutyroxybutane 生成 3-Hydroxybutyl butyrate
  参考文献：
  名称：

  DE, JESO B.;DROUILLARD, S.;DEGUELL-CASTAING, M.;SAUX, A.;MAILLARD, B., SYNTH. COMMUN., 18,(1988) N 14, C. 1691-1697

  摘要：

  DOI：

文献信息

• Regioselective esterification of diols and triols with lipases in organic solvents
  作者：V.S. Parmar、Rita Sinha、K.S. Bisht、Sandhya Gupta、A.K. Prasad、Poonam Taneja

  DOI：10.1016/s0040-4020(01)89922-1

  日期：1993.5

  Lipases from porcine pancreas (PPL) and Candida cylindracea (CCL) in different organic solvents allow discrimination of the primary and secondary hydroxyl groups, and also between two primary hydroxyl groups towards acylation with 2,2,2-trifluoroethyl butyrate in diols and triols with high regioselectivity.

  来自猪胰腺（PPL）和Candida cylindracea（CCL）的脂肪酶在不同的有机溶剂中可以区分伯羟基和仲羟基，也可以区分两个伯羟基之间的二醇和三醇中的2,2,2-三氟乙基丁酸酯的酰化。高区域选择性。
• SELECTIVE TRIMERIZATION OF ALIPHATIC ALDEHYDES CATALYZED BY POLYNUCLEAR CARBONYLFERRATES
  作者：Keiji Ito、Nobuhiro Kamiyama、Saburo Nakanishi、Yoshio Otsuji

  DOI：10.1246/cl.1983.657

  日期：1983.5.5

  Aliphatic aldehydes undergo a catalytic trimerization to give 1,3-diol monoesters upon treatment with Fe3(CO)12 in pyridine or with Fe3(CO)12-pyridine N-oxide in benzene. Polynuclear carbonylferrates serve as catalyst for this transformation.

  脂肪族醛在Fe3(CO)12催化下于吡啶中，或与Fe3(CO)12-吡啶N-氧化物在苯中处理时，会发生催化三聚反应生成1,3-二醇单酯。多核羰基合铁化合物在反应中起催化作用。
• Porcine pancreatic lipase mediated selective acylation of primary alcohols in organic solvents
  作者：Sowmianarayanan Ramaswamy、Brian Morgan、Allan.C. Oehlschlager

  DOI：10.1016/s0040-4039(00)97408-2

  日期：1990.1

  Porcine pancreatic lipase mediated acylation of 1,n-diols and triols affords primary acylated products in high yields.

  猪胰脂肪酶介导的1，n-二醇和三醇的酰化作用可提供高收率的初级酰化产物。
• Optically active compounds, their preparation and their use in liquid crystal compositions and liquid crystal optical modulators
  申请人：HITACHI, LTD.

  公开号：EP0322862A2

  公开（公告）日：1989-07-05

  The invention relates to optically active compounds represented by the general formula I wherein n, R1, R2, R3, R4., Q1, Q2, Q3, and M are defined as in the specification, methods and intermediates for their preparation, liquid crystal compositions comprising at least one optically active compound of formula I and their use in electrooptical display, switching and modulation devices.

  本发明涉及通式 I 所代表的光学活性化合物，其中 n、R1、R2、R3、R4. 其中 n、R1、R2、R3、R4.、Q1、Q2、Q3 和 M 的定义如说明书中所述，还涉及制备它们的方法和中间体、包含至少一种式 I 的光学活性化合物的液晶组合物以及它们在光电显示、开关和调制装置中的用途。
• Active agents and methods of their use for the treatment of metabolic disorders and nonalcoholic fatty liver disease
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US10953027B2

  公开（公告）日：2021-03-23

  Disclosed herein are active agents, compositions containing them, unit dosage forms containing them, and methods of their use, e.g., for treating a metabolic disorder or nonalcoholic fatty liver disease or for modulating a metabolic marker or nonalcoholic fatty liver disease marker.

  本文公开了活性剂、含有活性剂的组合物、含有活性剂的单位剂型以及活性剂的使用方法，例如用于治疗代谢紊乱或非酒精性脂肪肝或调节代谢标志物或非酒精性脂肪肝标志物。