tert-butyl-[(2S)-1-[2-[(2S)-2-methoxy-4-phenylmethoxybutyl]-1,3-dithian-2-yl]propan-2-yl]oxy-dimethylsilane | 1000866-29-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl-[(2S)-1-[2-[(2S)-2-methoxy-4-phenylmethoxybutyl]-1,3-dithian-2-yl]propan-2-yl]oxy-dimethylsilane
• CAS: 1000866-29-4
• 化学式: C₂₅H₄₄O₃S₂Si
• 分子量: 484.84
• InChiKey: QYZNWEHLVKSGEX-GMAHTHKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.37
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  78.3
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl-[(2S)-1-[2-[(2S)-2-methoxy-4-phenylmethoxybutyl]-1,3-dithian-2-yl]propan-2-yl]oxy-dimethylsilane 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以97%的产率得到(2S)-1-[2-[(2S)-2-methoxy-4-phenylmethoxybutyl]-1,3-dithian-2-yl]propan-2-ol
  参考文献：
  名称：

  First Total Syntheses and Spectral Data Corrections of 11-α-Methoxycurvularin and 11-β-Methoxycurvularin

  摘要：

  [Graphics]Concise and efficient total syntheses of 11-alpha-methoxycurvularin and 11-beta-methoxycurvularin were accomplished for the first time. The three-component linchpin coupling and intramolecular acylation reactions were key steps, in which we found the spectral data of 11-alpha-methoxycurvularin and 11-beta-methoxycurvularin, reported in the literature, were reversed with each other.

  DOI：

  10.1021/jo701885n
• 作为产物：
  描述：

  (-)-(S)-4-(苄氧基)-1,2-环氧丁烷 、 2-(叔丁基二甲基甲硅烷基)-1,3-二噻烷 、 S-环氧丙烷 、 碘甲烷 在 正丁基锂 、 六甲基磷酰三胺 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.5h， 以76%的产率得到tert-butyl-[(2S)-1-[2-[(2S)-2-methoxy-4-phenylmethoxybutyl]-1,3-dithian-2-yl]propan-2-yl]oxy-dimethylsilane
  参考文献：
  名称：

  First Total Syntheses and Spectral Data Corrections of 11-α-Methoxycurvularin and 11-β-Methoxycurvularin

  摘要：

  [Graphics]Concise and efficient total syntheses of 11-alpha-methoxycurvularin and 11-beta-methoxycurvularin were accomplished for the first time. The three-component linchpin coupling and intramolecular acylation reactions were key steps, in which we found the spectral data of 11-alpha-methoxycurvularin and 11-beta-methoxycurvularin, reported in the literature, were reversed with each other.

  DOI：

  10.1021/jo701885n

文献信息

• First Total Syntheses and Spectral Data Corrections of 11-α-Methoxycurvularin and 11-β-Methoxycurvularin
  作者：Qiren Liang、Yongquan Sun、Binxun Yu、Xuegong She、Xinfu Pan

  DOI：10.1021/jo701885n

  日期：2007.12.1

  [Graphics]Concise and efficient total syntheses of 11-alpha-methoxycurvularin and 11-beta-methoxycurvularin were accomplished for the first time. The three-component linchpin coupling and intramolecular acylation reactions were key steps, in which we found the spectral data of 11-alpha-methoxycurvularin and 11-beta-methoxycurvularin, reported in the literature, were reversed with each other.