ethyl 4-((1,3-dimethyl-2-oxoindolin-3-yl)methyl)benzoate | 1618656-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 4-((1,3-dimethyl-2-oxoindolin-3-yl)methyl)benzoate
• 英文别名: Ethyl 4-[(1,3-dimethyl-2-oxoindol-3-yl)methyl]benzoate；ethyl 4-[(1,3-dimethyl-2-oxoindol-3-yl)methyl]benzoate
• CAS: 1618656-94-2
• 化学式: C₂₀H₂₁NO₃
• 分子量: 323.392
• InChiKey: DMGJGIPDTRRHPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对碘苯甲酸乙酯 在 tetrafluoroboric acid 、 copper(II) bis(trifluoromethanesulfonate) 、 间氯过氧苯甲酸 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 生成 ethyl 4-((1,3-dimethyl-2-oxoindolin-3-yl)methyl)benzoate
  参考文献：
  名称：

  Copper-Catalyzed Diarylation of Activated Alkenes with Diaryliodonium Salts

  摘要：

  Cu(OTf)(2)-catalyzed diarylation of activated alkenes by using diaryliodonium(III) salts has been developed. With this method, arylated oxindoles can be easily accessed in good yields. Insights into the mechanism of copper-catalyzed arylations are discussed, and the findings are expected to help increase the level of understanding of catalytic arylations with diaryliodonium salts.

  DOI：

  10.1055/s-0033-1339004

文献信息

• Copper-Catalyzed Diarylation of Activated Alkenes with Diaryliodonium Salts
  作者：Jianwei Han、Limin Wang、Yang Yang、Xunshen Wu、Song Mao、Jianjun Yu

  DOI：10.1055/s-0033-1339004

  日期：——

  Cu(OTf)(2)-catalyzed diarylation of activated alkenes by using diaryliodonium(III) salts has been developed. With this method, arylated oxindoles can be easily accessed in good yields. Insights into the mechanism of copper-catalyzed arylations are discussed, and the findings are expected to help increase the level of understanding of catalytic arylations with diaryliodonium salts.