5-(4-硝基苯基)呋喃-2-碳酰肼 | 103566-27-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-(4-硝基苯基)呋喃-2-碳酰肼
• 英文名称: 5-(4-nitrophenyl) furan-2-carbohydrazide
• 英文别名: 5-(4-nitrophenyl)furan-2-carbohydrazide；5-<4-Nitro-phenyl>-furan-carbonsaeure-(2)-hydrazid；5-(4-Nitro-phenyl)-furan-carbonsaeure-(2)-hydrazid
• CAS: 103566-27-4
• 化学式: C₁₁H₉N₃O₄
• 分子量: 247.21
• InChiKey: RZKRLNOTPUDJMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(4-硝基苯基)呋喃-2-碳酰肼 、 4-氟苯乙酮 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 以59%的产率得到N-[1-(4-fluorophenyl)ethylideneamino]-5-(4-nitrophenyl)furan-2-carboxamide
  参考文献：
  名称：

  Discovery of molecules for the treatment of neuropathic pain: Synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones

  摘要：

  Neuropathic pain is a chronic pain condition that occurs and persists in a heterogeneous group of etiologically different diseases characterized by a primary lesion or dysfunction of the peripheral or central nervous system. Current treatment options do not provide adequate relief for many patients and a significant number of the agents used have dose limiting side effects. During the course of our work on the synthesis and screening of new drugs for the treatment of neuropathic pain, we have identified 5-(4-nitrophenyl)furoic-2-acid hydrazones which showed significant antiallodynic and antihyperalgesic activities in a chronic constriction injury (CCI) model of neuropathic pain in rat. Synthesized compounds thus represent a promising lead for new drug development for the treatment of neuropathic pain. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.04.021
• 作为产物：
  描述：

  ethyl 5-(4-nitrophenyl)furan-2-carboxylate 在 一水合肼 作用下， 以 甲醇 为溶剂， 反应 0.17h， 以64%的产率得到5-(4-硝基苯基)呋喃-2-碳酰肼
  参考文献：
  名称：

  Discovery of molecules for the treatment of neuropathic pain: Synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones

  摘要：

  Neuropathic pain is a chronic pain condition that occurs and persists in a heterogeneous group of etiologically different diseases characterized by a primary lesion or dysfunction of the peripheral or central nervous system. Current treatment options do not provide adequate relief for many patients and a significant number of the agents used have dose limiting side effects. During the course of our work on the synthesis and screening of new drugs for the treatment of neuropathic pain, we have identified 5-(4-nitrophenyl)furoic-2-acid hydrazones which showed significant antiallodynic and antihyperalgesic activities in a chronic constriction injury (CCI) model of neuropathic pain in rat. Synthesized compounds thus represent a promising lead for new drug development for the treatment of neuropathic pain. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.04.021

文献信息

• Large Second‐Order NLO Activity in Poly(4‐vinylpyridine) Grafted with Pd ^II and Cu ^II Chromophoric Complexes with Tridentate Bent Ligands Containing Heterocycles
  作者：Fabio Borbone、Antonio Carella、Ugo Caruso、Giuseppina Roviello、Angela Tuzi、Principia Dardano、Stefano Lettieri、Pasqualino Maddalena、Alberto Barsella

  DOI：10.1002/ejic.200701171

  日期：2008.4

  Two N-salicylidene-N'-acylhydrazines tridentate ligands containing heterocycles were prepared and utilized for the synthesis of mononuclear acentric complexes of Cu-II and Pd-II and pyridine serves as an additional ligand ((MLPy)-Py-x, M = metal, L-x = li

  制备了两个含有杂环的 N-水杨基-N'-酰基肼三齿配体，用于合成 Cu-II 和 Pd-II 的单核无着丝粒配合物，吡啶作为额外的配体 ((MLPy)-Py-x, M =金属，Lx = li
• A novel smart organogel which could allow a two channel anion response by proton controlled reversible sol–gel transition and color changes
  作者：You-Ming Zhang、Qi Lin、Tai-Bao Wei、Xiao-Ping Qin、Yan Li

  DOI：10.1039/b911125e

  日期：——

  A super gelator (F3) with an excellent gelation ability was synthesized; the organogel of F3 could allow two channel recognition of F−, AcO− and H2PO4− through proton controlled reversible sol–gel transition and color changes.

  合成了具有优异凝胶能力的超级凝胶剂（F3）； F3的有机凝胶可以通过质子控制的可逆溶胶-凝胶转变和颜色变化实现F-、AcO-和H2PO4-的双通道识别。
• OLEJNIK A. F.; VOZYAKOVA T. I.; NOVITSKIJ K. YU.; ZYKOVA T. N.; GUSKOVA T+, XIM.-FARMATSEVT. ZH. <KNFZ-AN>, 1976, 10, HO 4, 46-49
  作者：OLEJNIK A. F.、 VOZYAKOVA T. I.、 NOVITSKIJ K. YU.、 ZYKOVA T. N.、 GUSKOVA T+

  DOI：——

  日期：——
• Discovery of molecules for the treatment of neuropathic pain: Synthesis, antiallodynic and antihyperalgesic activities of 5-(4-nitrophenyl)furoic-2-acid hydrazones
  作者：Perumal Yogeeswari、Niloufer Menon、Arvind Semwal、Muralidharan Arjun、Dharmarajan Sriram

  DOI：10.1016/j.ejmech.2011.04.021

  日期：2011.7

  Neuropathic pain is a chronic pain condition that occurs and persists in a heterogeneous group of etiologically different diseases characterized by a primary lesion or dysfunction of the peripheral or central nervous system. Current treatment options do not provide adequate relief for many patients and a significant number of the agents used have dose limiting side effects. During the course of our work on the synthesis and screening of new drugs for the treatment of neuropathic pain, we have identified 5-(4-nitrophenyl)furoic-2-acid hydrazones which showed significant antiallodynic and antihyperalgesic activities in a chronic constriction injury (CCI) model of neuropathic pain in rat. Synthesized compounds thus represent a promising lead for new drug development for the treatment of neuropathic pain. (C) 2011 Elsevier Masson SAS. All rights reserved.