4,N-dibutyl-aniline | 167864-23-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4,N-dibutyl-aniline
• 英文别名: 4-Butylamino-1-butyl-benzol；4,N-Dibutyl-anilin；N,4-dibutylaniline
• CAS: 167864-23-5
• 化学式: C₁₄H₂₃N
• mdl: MFCD11123735
• 分子量: 205.343
• InChiKey: PIEKAOJPGHYSLM-UHFFFAOYSA-N

物化性质

• 沸点：
  309.9±21.0 °C(Predicted)
• 密度：
  0.915±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4,N-dibutyl-aniline 在 盐酸 、 亚硝酸 作用下， 生成 4,N-dibutyl-N-nitroso-aniline
  参考文献：
  名称：

  Reilly; Hickinbottom, Journal of the Chemical Society, 1920, vol. 117, p. 133

  摘要：

  DOI：
• 作为产物：
  描述：

  1-正-丁基-4-碘苯 、 正丁胺 在 1,1'-双(二苯基膦)二茂铁 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以47%的产率得到4,N-dibutyl-aniline
  参考文献：
  名称：

  Sterically Hindered Chelating Alkyl Phosphines Provide Large Rate Accelerations in Palladium-Catalyzed Amination of Aryl Iodides, Bromides, and Chlorides, and the First Amination of Aryl Tosylates

  摘要：

  DOI：

  10.1021/ja981318i

文献信息

• Synthesis of quinolines via ruthenium-catalysed amine exchange reaction between anilines and trialkylamines
  作者：Chan Sik Cho、Byoung Ho Oh、Joon Seok Kim、Tae-Jeong Kim、Sang Chul Shim

  DOI：10.1039/b005966h

  日期：——

  Anilines react with an array of trialkylamines in the presence of a catalytic amount of RuCl3·nH2O and bis(diphenylphosphino)methane together with SnCl2·2H2O and hex-1-ene as hydrogen acceptor in dioxane at 180 °C to afford the corresponding 2,3-disubstituted quinolines in moderate to good yields.

  苯胺与一系列三烷基胺在催化量的 RuCl3-nH2O 和双（二苯基膦）甲烷以及 SnCl2-2H2O 和作为氢接受体的 1-己烯的存在下，于二噁烷中在 180 °C 下发生反应，生成相应的 2,3-二取代喹啉，收率中等至良好。
• FR2234293
  申请人：——

  公开号：——

  公开（公告）日：——
• Hickinbottom, Journal of the Chemical Society, 1927, p. 66
  作者：Hickinbottom

  DOI：——

  日期：——
• Systematic Variation of Bidentate Ligands Used in Aryl Halide Amination. Unexpected Effects of Steric, Electronic, and Geometric Perturbations
  作者：Blake C. Hamann、John F. Hartwig

  DOI：10.1021/ja9721881

  日期：1998.4.1

  This paper presents effects of varying bidentate phosphine steric properties, electronic properties, and bite angle on product ratios in the amination of aryl bromides. Comparisons of the ratios of amine products to dehydrohalogenation products showed that catalysts containing electron rich, modestly hindered phosphines with small bite angles (similar to 90 degrees) gave the best selectivities. Surprisingly, the arene side product formed from reaction of alkylamines deuterated in the N-H position or deuterated in the position or to the nitrogen showed low levels of deuterium incorporation in many examples. Steric properties and ligand bite angle had the greatest impact on the selectivity for monoarylation versus diarylation of primary amines: ligands with small bite angles gave higher monoarylation-to-diarylation ratios, as did ligands with increased steric bulk. Electron poor or sterically hindered bidentate phosphines reduced the amount of product resulting from aryl exchange of electron rich palladium-bound arenes with those of aryl groups on the phosphine ligands.
• AMINE DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY AND THE USES THEREOF
  申请人：OKUNO Takayuki

  公开号：US20100273842A1

  公开（公告）日：2010-10-28

  This invention provides an anorectic or anti-obesity composition comprising a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is optionally substituted lower alkyl, Y is —S(O) n — wherein n is 1 or 2, or —CO—, R 2 is hydrogen or lower alkyl, R 7 is hydrogen or lower alkyl, X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, and Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like.