(R)-(+)-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-6,6'-dimethyl-1,1'-binaphthyl | 355392-51-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-(+)-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-6,6'-dimethyl-1,1'-binaphthyl
• 英文别名: 2,2'-bis[bis-(3,5-dimethylphenyl)phosphino]-6,6'-dimethyl-1,1'-binaphthyl；[1-[2-Bis(3,5-dimethylphenyl)phosphanyl-6-methylnaphthalen-1-yl]-6-methylnaphthalen-2-yl]-bis(3,5-dimethylphenyl)phosphane；[1-[2-bis(3,5-dimethylphenyl)phosphanyl-6-methylnaphthalen-1-yl]-6-methylnaphthalen-2-yl]-bis(3,5-dimethylphenyl)phosphane
• CAS: 355392-51-7
• 化学式: C₅₄H₅₂P₂
• 分子量: 762.954
• InChiKey: LXJCKPKEBQQBDC-UHFFFAOYSA-N

物化性质

• 沸点：
  844.3±65.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  15.1
• 重原子数：
  56
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  三乙烯二胺 、 (R)-6,6'-dimethyl-1,1'-bi-2-naphthol Bis(Trifluoromethanesulfonate) 、 氯二(3,5-二甲基苯基)膦 在 palladium/activated carbon 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (R)-(+)-2,2'-bis[bis(3,5-dimethylphenyl)phosphino]-6,6'-dimethyl-1,1'-binaphthyl
  参考文献：
  名称：

  Process for preparing optically active secondary alcohols having nitrogenous or oxygenic functional groups

  摘要：

  通过使用钌/光学活性双齿膦/二胺配合物作为催化剂，在存在氢气的情况下或与碱一起，通过不对称地氢化具有氮或氧官能团在α、β和γ位置中的酮化合物（1）来制备通式（3）的光学活性二级醇，[其中R1是线性低碳烷基、芳香环基等；A是CH2NR2R3或类似物；n是0到2的整数；*代表不对称碳原子]。通过该过程获得的光学活性二级醇可用作药物及药物中间体的制备。

  公开号：

  US20030045727A1

文献信息

• HETEROGENEOUS RHODIUM METAL CATALYSTS
  申请人：Bergens Steven H.

  公开号：US20130053576A1

  公开（公告）日：2013-02-28

  Novel polymeric rhodium catalysts having repeating subunits of Formula (I), wherein R 1 -R 8 , X, A, m, n and p are as defined in the application, are described along with methods of using these catalysts, as well as precursors therefor, in the chemical synthesis transformations.

  本发明涉及一种具有公式（I）的重复亚单位的新型聚合物铑催化剂，其中R1-R8、X、A、m、n和p如申请中所定义，以及使用这些催化剂的方法，以及它们的前体，在化学合成转化中的应用。
• PROCESS FOR PREPARING OPTICALLY ACTIVE SECONDARY ALCOHOLS HAVING NITROGENOUS OR OXYGENIC FUNCTIONAL GROUPS
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP1254885A1

  公开（公告）日：2002-11-06

  The present invention provides a process for the preparation of an optically active secondary alcohol represented by the general formula (3): wherein R1 represents a straight-chain lower alkyl group, an aromatic ring group, or the like; A represents CH2NR2R3, or the like; n is an integer of from 0 to 2; and * represents an asymmetric carbon atom, which comprises asymmetrically hydrogenating with selectivity among the functional groups, a ketone compound represented by the general formula (1) having a nitrogenous or oxygenic functional group at any of the α-, β- and γ-positions: wherein R1, A and n are as defined above, using a ruthenium/optically active bidentate phosphine/diamine complex as a catalyst in the presence of hydrogen or in the presence of hydrogen and a base. The optically active secondary alcohols obtained by the present process are useful as medicaments and intermediates for producing medicaments.

  本发明提供了一种由通式（3）表示的光学活性仲醇的制备方法： 其中 R1 代表直链低级烷基、芳香环基或类似基团；A 代表 CH2NR2R3 或类似基团；n 是 0 至 2 的整数；以及 * 代表不对称碳原子，其包括以官能团之间的选择性不对称氢化通式 (1) 所代表的酮化合物，该酮化合物在 α-、β- 和 γ- 位置上具有含氮或含氧官能团： 其中 R1、A 和 n 如上定义，使用钌/光学活性双齿膦/二胺络合物作为催化剂，在氢气存在下或在氢气和碱存在下进行。 通过本工艺获得的光学活性仲醇可用作药物和生产药物的中间体。
• CATIONIC TRANSITION METAL CATALYSTS
  申请人：Abdur-Rashid Kamaluddin

  公开号：US20100311975A1

  公开（公告）日：2010-12-09

  The present disclosure includes catiome complexes of iron, ruthenium, and osmium, and their use as catalysts in organic synthesis transformations including the hydrogenation of unsaturated compounds. The complexes are represented by the following formulae I, II, III, IV, and V, wherein M is Fe, Ru or Os, P is a monodentate ligand with a phosphorus donor atom, P2 is a bidentate neutral ligand with two phosphorus donor atoms, N 2 is a bidentate neutral ligand with two nitrogen donor atoms, PN is a bidentate neutral ligand with phosphorus and nitrogen donor atoms, PNNP is a tetradentate neutral ligand bonded to M via two phosphorus and two nitrogen atoms, X is any anionic ligand, LB is any neutral Lewis base, Y is any non-coordinating anion, n is 0, 1, or 2, m is 1 or 2, q is 0 or 1, r is 1 or 2 and q+r=2.
• US8962516B2
  申请人：——

  公开号：US8962516B2

  公开（公告）日：2015-02-24
• [EN] HETEROGENEOUS RHODIUM METAL CATALYSTS<br/>[FR] CATALYSEURS MÉTALLIQUES HÉTÉROGÈNES AU RHODIUM
  申请人：UNIV ALBERTA

  公开号：WO2011035445A1

  公开（公告）日：2011-03-31

  Novel polymeric rhodium catalysts having repeating subunits of Formula (I), wherein R1-R8, X, A, m, n and p are as defined in the application, are described along with methods of using these catalysts, as well as precursors therefor, in the chemical synthesis transformations.