1-(2-hydroxy-ethyl)-5-methyl-1,3-dihydro-benzoimidazol-2-one | 63387-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-(2-hydroxy-ethyl)-5-methyl-1,3-dihydro-benzoimidazol-2-one
• 英文别名: 1,3-dihydro-1-(2-hydroxyethyl)-5-methyl-2H-benzimidazol-2-one；1-(2-Hydroxyethyl)-5-methyl-1H-benzo[d]imidazol-2(3H)-one；3-(2-hydroxyethyl)-6-methyl-1H-benzimidazol-2-one
• CAS: 63387-92-8
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: IQWHFPFKJCSXMQ-UHFFFAOYSA-N

物化性质

• 密度：
  1.252±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  52.6
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氯化亚砜 、 氯仿 、 1-(2-hydroxy-ethyl)-5-methyl-1,3-dihydro-benzoimidazol-2-one 以12 parts (42%)的产率得到1-(2-chloro-ethyl)-5-methyl-1,3-dihydro-benzoimidazol-2-one
  参考文献：
  名称：

  1-Benzazolylalkyl-4-substituted-piperidines

  摘要：

  苯并咪唑烷基哌啶衍生物类化合物，可用作抗精神病药物。

  公开号：

  US04035369A1
• 作为产物：
  描述：

  1,3-dihydro-1-(2-hydroxyethyl)-5-methyl-3-(1-methylethenyl)-2H-benzimidazol-2-one 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 以22.3 parts (58%)的产率得到1-(2-hydroxy-ethyl)-5-methyl-1,3-dihydro-benzoimidazol-2-one
  参考文献：
  名称：

  1-Benzazolylalkyl-4-substituted-piperidines

  摘要：

  苯并咪唑烷基哌啶衍生物类化合物，可用作抗精神病药物。

  公开号：

  US04035369A1

文献信息

• 4-HETEROCYCLOALKYLPYRI(MI)DINES, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
  申请人：Engelhardt Harald

  公开号：US20090203673A1

  公开（公告）日：2009-08-13

  The present invention encompasses compounds of general Formula (I) wherein X and R 1 to R 3 are defined as in claim 1 , which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

  本发明涵盖一般式（I）中定义为权利要求1中定义的X和R1到R3的化合物，适用于治疗以细胞过度或异常增殖为特征的疾病，并且利用其制备具有上述特性的制药组合物。
• THERMOPLASTIC POLYMER, THERMOPLASTIC POLYMER COMPOSITION, ANTISTATIC AGENT, AND RESIN COMPOSITION
  申请人：MITSUI TAKEDA CHEMICALS, INC.

  公开号：EP1541608A1

  公开（公告）日：2005-06-15

  A thermoplastic polymer compound can be obtained by allowing a compound having a bivalent organic group to react with a polyoxyalkylene diol obtained by addition-polymerization of an urea compound having a partial structure refractivity of 14 to 35 and a dipole moment of 2.5D to 5.5D with an alkylene oxide. A thermoplastic polymer composition comprises the thermoplastic polymer compound and an inorganic salt of an alkali metal or the like. The polymer compound and the polymer composition are useful as an antistatic agent and have excellent antistatic properties and excellent transparency.

  让具有二价有机基团的化合物与通过部分结构折射率为 14 至 35、偶极矩为 2.5D 至 5.5D 的脲化合物与环氧亚烷基加成聚合得到的聚氧亚烷基二元醇反应，可以得到一种热塑性聚合物化合物。热塑性聚合物组合物由热塑性聚合物化合物和碱金属或类似物质的无机盐组成。该聚合物化合物和聚合物组合物可用作抗静电剂，具有优异的抗静电性能和极佳的透明度。
• Thermoplastic polymer, thermoplastic polymer composition, antistatic agent, and resin composition
  申请人：Matsumoto Shinsuke

  公开号：US20060155096A1

  公开（公告）日：2006-07-13

  A thermoplastic polymer compound can be obtained by allowing a compound having a bivalent organic group to react with a polyoxyalkylene diol obtained by addition-polymerization of an urea compound having a partial structure refractivity of 14 to 35 and a dipole moment of 2.5 D to 5.5 D with an alkylene oxide. A thermoplastic polymer composition comprises the thermoplastic polymer compound and an inorganic salt of an alkali metal or the like. The polymer compound and the polymer composition are useful as an antistatic agent and have excellent antistatic properties and excellent transparency.

  让具有二价有机基团的化合物与通过部分结构折射率为 14 至 35、偶极矩为 2.5 D 至 5.5 D 的脲化合物与环氧亚烷基加成聚合得到的聚氧亚烷基二元醇反应，可以得到热塑性聚合物化合物。热塑性聚合物组合物由热塑性聚合物化合物和碱金属或类似物质的无机盐组成。该聚合物化合物和聚合物组合物可用作抗静电剂，具有优异的抗静电性能和极佳的透明度。
• INHIBITORS OF THE MENIN-MLL INTERACTION
  申请人：Vitae Pharmaceuticals, LLC

  公开号：US20210179611A1

  公开（公告）日：2021-06-17

  The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.
• US4035369A
  申请人：——

  公开号：US4035369A

  公开（公告）日：1977-07-12