2,8-Dihydroxydibenzofuran | 5914-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 2,8-Dihydroxydibenzofuran
• 英文别名: dibenzofuran-2,8-diol；2,8-Dihydroxy-dibenzofuran
• CAS: 5914-48-7
• 化学式: C₁₂H₈O₃
• 分子量: 200.194
• InChiKey: VXDZJGNEPGPUEG-UHFFFAOYSA-N

物化性质

• 熔点：
  243-244 °C
• 沸点：
  433.6±25.0 °C(Predicted)
• 密度：
  1.457±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,8-Dihydroxydibenzofuran 在 咪唑 、 盐酸 、 4-二甲氨基吡啶 、 正丁基锂 、 四甲基乙二胺 、 碘苯二乙酸 、 四丁基氟化铵 、 tetra-N-butylammonium tribromide 、 potassium carbonate 、 N,N-二异丙基乙胺 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 生成 3-Bromo-4a,8,9-trimethoxydibenzofuran-2-one
  参考文献：
  名称：

  Investigations into arylquinone atropisomers: synthesis and evaluation

  摘要：

  An arylquinone capable of existing as two diastereromeric atropisomers was synthesized starting from dibenzofuran. Arylquinone 12 exists as a set of slowly interchanging diastereomeric atropisomers and arylquinone 4 exists as rapidly interchanging atropisomers. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.214
• 作为产物：
  描述：

  二苯并呋喃 在 aluminum (III) chloride 、 乙酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 96.17h， 以4.38 g的产率得到2,8-Dihydroxydibenzofuran
  参考文献：
  名称：

  A Proton Conductive Aromatic Block Copolymer Containing Dibenzofuran Moieties

  摘要：

  在疏水部分提供刚性、平面二苯并呋喃的磺化芳香族嵌段共聚物，具有改善的膜性能，即良好的相分离、有效的水吸收、高质子导电性以及在广泛湿度范围内的适中机械强度。

  DOI：

  10.1246/cl.150242

文献信息

• Pharmaceutically useful oxygen containing heterocyclic derivatives
  申请人：Richardson-Merrell Inc.

  公开号：US03953602A1

  公开（公告）日：1976-04-27

  Compounds of the following general formula are useful in the treatment of conditions of delayed hypersensitivity: ##SPC1## Wherein X represents a bond, --CH.sub.2 --, or carbonyl; Y represents a vinylene group, ##EQU1## carbonyl, oxygen, divalent sulfur, or carbonyloxy with the proviso that when Y is ##EQU2## or vinylene, X is not carbonyl; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms with the proviso that when Y is vinylene, A contains from 1 to 5 carbon atoms and with the proviso that when Y is carbonyloxy or carbonylthio, A contains from 2 to 6 carbon atoms; each of R.sup.1 and R.sup.2 represents hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms; or alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than 1-position; and pharmaceutically acceptable acid addition salts thereof.

  以下一般公式的化合物在治疗延迟型超敏反应症状方面是有用的：##SPC1## 其中X代表键，-CH.sub.2-或羰基；Y代表乙烯基团，##EQU1## 羰基，氧，二价硫，或羰氧基，但当Y为##EQU2## 或乙烯基时，X不是羰基；A代表由1至6个碳原子的直链或支链烷基链，但当Y为乙烯基时，A含有1至5个碳原子，且当Y为羰氧基或羰硫基时，A含有2至6个碳原子；R.sup.1和R.sup.2中的每一个代表氢，由1至4个碳原子的直链或支链较低烷基基团；或具有3至6个碳原子，并且不在1-位置具有乙烯不饱和度的烯基；以及其药学上可接受的酸盐。
• Pharmaceutically useful nitrogen containing heterocyclic derivatives
  申请人：Richardson-Merrell Inc.

  公开号：US03937833A1

  公开（公告）日：1976-02-10

  Bis-basic substituted aromatic polycyclic compounds of the following structure are useful in treating conditions of delayed hypersensitivity: ##SPC1## Wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, dibenzofuran, dibenzothiophene, carbazole, N-(lower)alkyl carbazole, xanthene, xanthone, thioxanthene, phenoxathiin, or anthraquinone; Y represents carbonyloxy, carbonylthio, oxygen, divalent sulfur or carbonyl with the provisos that when Y is carbonyloxy or carbonylthio, [W] is other than thioxanthene, phenoxathiin or anthraquinone, when Y is oxygen or divalent sulfur, [W] is other than thioxanthene or phenoxathiin, and when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms with the proviso that when Y is carbonyloxy or carbonylthio, A contains at least 2 straight chain carbon atoms, that is, an ethylene radical; R represents hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, phenyl or benzyl; and pharmaceutically useful acid addition salts.

  以下结构的Bis-基取代芳香族多环化合物在治疗延迟型超敏反应方面很有用：##SPC1## 其中[W]代表从荧蒽、芴、芴-9-醇、芴-9-酮、二苯并呋喃、二苯并噻吩、咔唑、N-(较低)烷基咔唑、苯酚氧噻吩或蒽醌中选的芳香族多环核；Y代表羰氧基、羰硫基、氧、二价硫或羰基，但当Y为羰氧基或羰硫基时，[W]不是噻吩、苯酚氧噻吩或蒽醌，当Y为氧或二价硫时，[W]不是噻吩或苯酚氧噻吩，当Y为羰基时，[W]不是芴-9-醇或蒽醌；A代表1至6个碳原子的直链或支链烷基链，但当Y为羰氧基或羰硫基时，A含有至少2个直链碳原子，即乙烯基；R代表氢、1至4个碳原子的直链或支链低级烷基、苯基或苄基；以及药用酸盐。
• COPOLYMER AND POLYMER LIGHT EMITTING DEVICE USING THE SAME
  申请人：Suzuki Tomoyuki

  公开号：US20100176376A1

  公开（公告）日：2010-07-15

  A copolymer comprising a repeating unit of the following formula (1) and a repeating unit of the following formula (2): (wherein, a ring A and ring B represent each independently an aromatic ring optionally having a substituent. X is —O—, —S—, —S(═O)—, —S(═O) 2 —, —Si(R 1 ) 2 —Si(R 1 ) 2 —, —Si(R 1 ) 2 —, —, —B(R 1 )—, —P(R 1 )—, —P(═O)(R 1 )—, —O—C(R 1 ) 2 — or —N═C(R 1 )—, and R 1 represents a substituent. When there are two or more R 1 s in the same formula, they may be the same or different.) (wherein, Y is —O—, —S— or —C(═O)—. Ar 1 represents an aryl group optionally having a substituent or a monovalent heterocyclic group optionally having a substituent, and there is no substituent connected to atoms of the ring of Ar 1 , the atoms being adjacent an atom of Ar 1 connected to a nitrogen atom in the formula. R 3 represents a substituent, and n represents an integer of from 0 to 3. When there are two or more R 2 s in the formula, they may be the same or different.).

  一种共聚物，包含如下式(1)的重复单元和如下式(2)的重复单元：（其中，环A和环B各自独立地表示具有取代基的芳香环。X是-O-、-S-、-S（═O）-、-S（═O）2-、-Si（R1）2-Si（R1）2-、-Si（R1）2-、-、-B（R1）-、-P（R1）-、-P（═O）（R1）-、-O-C（R1）2-或-N═C（R1）-，R1表示一个取代基。当在同一式中有两个或更多的R1时，它们可以相同或不同。）（其中，Y是-O-、-S-或-C（═O）-。Ar1表示一个具有取代基的芳基团或一个具有取代基的单价杂环基团，并且没有取代基连接到Ar1的环上的原子，这些原子相邻于公式中连接到氮原子的Ar1的原子。R3表示一个取代基，n表示从0到3的整数。当在公式中有两个或更多的R2时，它们可以相同或不同。）
• Process for producing polymer
  申请人：Ohuchi Kazuei

  公开号：US20090209715A1

  公开（公告）日：2009-08-20

  A process for producing a polymer, characterized by comprising the following step (A) and step (B). (A) A step in which a polymer having repeating units represented by the general formula (1): —Ar 1 — (wherein Ar 1 represents an arylene, divalent heterocyclic, or divalent aromatic amine group having at least one C—H bond on the aromatic ring) is used as a raw material and one or more of the C—H bond(s) on the aromatic ring are converted to thereby produce a polymer having repeating units which have one or more characteristic groups X and are represented by the general formula (2): (wherein X represents a characteristic group; Ar 2 represents an arylene group, heterocyclic group, or aromatic amine group which each has a valence of n+2 and in each of which n of the C—H bonds on the aromatic ring of Ar 1 have been converted into a C—X bond; and n is an integer of 1-4) (hereinafter, this polymer is referred to as polymer having the characteristic group (X)). (B) A step in which the polymer having the characteristic group (X) produced in the step (A) is reacted with a compound having a characteristic group (Y) which reacts with the characteristic group (X) to form a bond.

  一种制备聚合物的方法，其特征在于包括以下步骤（A）和步骤（B）。 （A）使用具有由通式（1）表示的重复单元的聚合物作为原料，并将芳香环上的一个或多个C-H键转化，从而产生具有一个或多个特征基团X的重复单元的聚合物，该聚合物由通式（2）表示：（其中X表示特征基团；Ar2表示具有n+2价的芳香族、杂环族或芳香胺基团，其中每个基团的Ar1芳香环上的n个C-H键已转化为C-X键；n是1-4的整数）（以下简称具有特征基团（X）的聚合物）。 （B）将在步骤（A）中生产的具有特征基团（X）的聚合物与具有与特征基团（X）反应形成键的特征基团（Y）的化合物反应。
• AROMATIC POLYMER
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1892256A1

  公开（公告）日：2008-02-27

  Disclosed is an aromatic polymer containing one or more repeating units represented by the following formula (1). (In the formula, Ar1 represents an arylene group having a fused ring structure or a divalent heterocyclic compound group having a π-conjugated system, and contains a group represented by the formula (2) below. This group is bonded to a carbon atom having a sp2 hybrid orbital which is contained in a ring of the ring structure of the arylene group having a fused ring structure or the divalent heterocyclic compound group having a π-conjugated system represented by Ar1. (In the formula (2), E1 represents a hydrogen atom, a halogen atom or a monovalent organic group; Ar2 represents a group having a divalen-t π-conjugated cyclic compound residue, and two Ar2's may be the same as or different from each other; X1 represents a divalent group selected from the group consisting of -NQ1-, -PQ2- and -BQ3-, and Q1-Q3 independently represent a substituent; Z represents a direct bond or a divalent linking group, and two Z's may be the same as or different from each other; mi' s respectively represent 0 or 1; and in case where two X1's exist, they may be the same as or different from each other.)

  本发明公开了一种芳香族聚合物，该聚合物含有一个或多个由下式(1)表示的重复单元。(式中，Ar1 代表具有融合环结构的芳烯基团或具有π-共轭体系的二价杂环化合物基团，并含有下式（2）所代表的基团。该基团与具有 sp2 杂化轨道的碳原子键合，该碳原子包含在具有融合环结构的芳烯基团或具有 Ar1 所代表的 π 共轭体系的二价杂环化合物基团的环结构中。(在式 (2) 中，E1 代表氢原子、卤素原子或一价有机基团；Ar2 代表具有二价π-共轭环状化合物残基的基团，两个 Ar2 可以相同或不同；X1代表选自-NQ1-、-PQ2-和-BQ3-组成的组的二价基团，Q1-Q3独立地代表取代基；Z代表直接键或二价连接基团，两个Z可以相同或不同；mi's分别代表0或1；如果存在两个X1，它们可以相同或不同。)