N-acetyl-2-phenylacetamide | 10543-56-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-acetyl-2-phenylacetamide
• 英文别名: N-(Phenylacetyl)acetamide；N-(Phenylacetyl)acetamid；n-acetylphenylacetamide；acetyl-phenylacetyl-amine；Acetyl-phenylacetyl-amin；N-Acetyl-phenacetamid
• CAS: 10543-56-3
• 化学式: C₁₀H₁₁NO₂
• 分子量: 177.203
• InChiKey: VJYZIJKLUPUIKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2925190090

反应信息

• 作为反应物：
  描述：

  N-acetyl-2-phenylacetamide 、 ammonium hydroxide 生成 2-苯乙酰胺
  参考文献：
  名称：

  DOROFEENKO G. N.; KARPENKO V. D.; RYABUXIN YU. I.; KITAJGORODSKAYA S. A., ZH. OBSHCH. XIMII, 1978, 48, HO 10, 2254-2257

  摘要：

  DOI：
• 作为产物：
  描述：

  2-苯乙酰胺 在 盐酸 作用下， 生成 N-acetyl-2-phenylacetamide
  参考文献：
  名称：

  Mikhailov,B.M. et al., Journal of general chemistry of the USSR, 1972, vol. 42, p. 1545 - 1549

  摘要：

  DOI：

文献信息

• Synthesis of 1,3,5-trisubstituted-1,2,4-triazoles by microwave-assisted N-acylation of amide derivatives and the consecutive reaction with hydrazine hydrochlorides
  作者：Jongbok Lee、Myengchan Hong、Yoonchul Jung、Eun Jin Cho、Hakjune Rhee

  DOI：10.1016/j.tet.2012.01.003

  日期：2012.2

  Facile and efficient procedures for the N-acylation reaction of amide derivatives with various acid anhydrides and the cyclization reaction of N-acylated amide derivatives with various hydrazine hydrochlorides were described. The reactions were carried out under microwave irradiation to give products in good yields in a few minutes. The synthesis of 1,3,5-trisubstituted-1,2,4-triazoles from benzamides

  描述了酰胺衍生物与各种酸酐的N-酰化反应以及N-酰化的酰胺衍生物与各种肼盐酸盐的环化反应的简便有效的方法。反应在微波辐射下进行，在几分钟内以高收率得到产物。由苯甲酰胺合成1,3,5-三取代-1,2,4-三唑也可以通过简单的一锅顺序反应来完成。
• Ag-Catalyzed Chemoselective Decarboxylative Mono- and <i>gem</i>-Difluorination of Malonic Acid Derivatives
  作者：Zhen Wang、Cong-Ying Guo、Cheng Yang、Jian-Ping Chen

  DOI：10.1021/jacs.9b00681

  日期：2019.4.10

  Malonic acid derivatives have been successfully applied in a Ag-catalyzed decarboxylative fluorination reaction, providing an unprecedented route to either gem-difluoroalkanes or α-fluorocarboxylic acids by the judicious selection of base and solvent. This reaction features the use of readily available starting materials, tunable chemoselectivity and good functional group compatibility as well as gram-scale

  丙二酸衍生物已成功应用于银催化的脱羧氟化反应，通过明智地选择碱和溶剂，为制备偕二氟烷烃或α-氟羧酸提供了前所未有的途径。该反应的特点是使用容易获得的起始材料、可调的化学选择性和良好的官能团兼容性以及克级合成能力。在这种自由基脱羧官能化中使用丙二酸衍生物的优势通过 α-氟代羧酸向有价值的含氟化合物的轻松转化而进一步突出。初步的机理研究表明，α-羧酸自由基参与了该反应。
• Process for preparing 4-haloazetidin-2-ones
  申请人：ELI LILLY AND COMPANY

  公开号：EP0060120A1

  公开（公告）日：1982-09-15

  A process for preparing 4-haloazetidinones of the formu- which comprises reacting in an inert solvent at a temperature between about -20°C. and about 45°C. a 4-sulfino- azetidinone of the formula with at least one molar equivalent of a positive halogen reagent, where in the above formulas M is hydrogen, sodium or potassium, X is chloro, bromo, or iodo; R is a carboxy-protecting group; and R, is an acylamido or diacylamido group useful as intermediates for the preparation of β-lactam antibiotics.

  一种制备式-4-卤代氮杂环丁酮的工艺 式的 4-氨基磺氮杂环丁酮与至少一种摩尔当量的正卤素试剂反应。 式中 M 为氢、钠或钾，X 为氯、溴或碘；R 为羧基保护基团；R 为酰氨基或二酰基氨基，可用作制备 β-内酰胺类抗生素的中间体。
• Heterocyclic compounds having anti-diabetic activity, their preparation and their use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0676398A2

  公开（公告）日：1995-10-11

  Compounds of formula (I) : [wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group ; Y represents an oxygen or sulphur atom ; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or N-hydroxyureidomethyl group ; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group ; and m is an integer of from 1 to 5] have hypoglycemic and anti-diabetic activities.

  式(I)化合物： 其中X 代表未取代或取代的吲哚基、吲哚啉基、氮杂吲哚啉基、咪唑吡啶基或咪唑嘧啶基； Y 代表氧原子或硫原子；Z 代表 2,4-二氧代噻唑啉-5-亚甲基、2,4-二氧代噻唑啉-5-基甲基、2,4-二氧代恶唑啉-5-基甲基、3,5-二氧代恶唑啉-2-基甲基或 N-羟基脲基甲基；R 代表氢原子、烷基、烷氧基、卤素原子、羟基、硝基、芳烷基或未取代或取代的氨基；以及 m 是 1 至 5 的整数]具有降血糖和抗糖尿病活性。
• n-Butylammonium carboxylates/Tf2O: ionic liquid based systems for the synthesis of unsymmetrical imides via a Ritter-type reaction
  作者：Mohammad Mehdi Khodaei、Ehsan Nazari

  DOI：10.1016/j.tetlet.2012.03.121

  日期：2012.6

  We have developed a new method for the preparation of unsymmetrical imides using liquid carboxylate salts via a Ritter-type process. The reactions were carried out with nitriles and n-butylammonium carboxylates as ionic liquids in the presence of triflic anhydride (Tf2O) as the promoter. Mild reaction conditions, simplicity of the procedure, and proton-free conditions are the main advantages of this procedure. (C) 2012 Elsevier Ltd. All rights reserved.