2,3-dichloropropyl benzoate | 856816-70-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-dichloropropyl benzoate
• CAS: 856816-70-1
• 化学式: C₁₀H₁₀Cl₂O₂
• 分子量: 233.094
• InChiKey: PUDNUPVEGKLDCI-UHFFFAOYSA-N

物化性质

• 沸点：
  329.3±32.0 °C(Predicted)
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯甲酸烯丙酯 在 四氯化碳 、 氯 、 甲烷 作用下， 生成 2,3-dichloropropyl benzoate
  参考文献：
  名称：

  Ing, Journal of the Chemical Society, 1948, p. 1394

  摘要：

  DOI：

文献信息

• Synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by ZnO
  作者：Yuqi Tang、Chengliang Feng、Wanfeng Yang、Min Ji、Wei Wang、Junqing Chen

  DOI：10.1007/s11696-020-01267-2

  日期：2021.1

  An efficient method for the synthesis of chloroesters by the reaction of ethers with acyl chlorides catalyzed by nano-ZnO under solvent-free condition at room temperature was described. The method is compatible with a range of ethers including tricyclic ethers, tetracyclic ethers, pentacyclic ethers and hexacyclic ethers and have afforded the products with moderate to good yields. The ZnO could be

  介绍了一种在室温无溶剂条件下，在纳米ZnO催化下，醚与酰氯反应合成氯代酯的有效方法。该方法与包括三环醚、四环醚、五环醚和六环醚在内的一系列醚相容，并以中等至良好的收率提供了产物。ZnO最多可重复使用3次，3次循环后产品收率为87%。
• Mild and efficient method for the cleavage of cyclic and acyclic ethers by iodine under solvent-free conditions
  作者：J.S. Yadav、B.V.S. Reddy、P. Murali Krishna Reddy、Manoj K. Gupta

  DOI：10.1016/j.tetlet.2005.10.017

  日期：2005.12

  Ethers undergo smooth cleavage with acyl chlorides in the presence of a catalytic amount of elemental iodine under extremely mild conditions to give the corresponding halo esters. This new procedure offers significant advantages such as high conversions, short reaction times and enhanced selectivity together with mild reaction conditions, which makes it an attractive strategy.

  醚在极适度的条件下，在催化量的碘元素存在下，用酰氯进行平滑裂解，得到相应的卤代酯。该新方法具有显着的优势，例如高转化率，较短的反应时间和更高的选择性以及温和的反应条件，这使其成为一种有吸引力的策略。
• A mild and efficient synthesis of chloroesters by the cleavage of cyclic and acyclic ethers using Bi(NO₃)₃·5H₂O as a catalyst under solvent-free conditions
  作者：V Suresh、N Suryakiran、Y Venkateswarlu

  DOI：10.1139/v07-126

  日期：2007.12.1

  A facile, efficient synthesis of chloroesters is described. The reaction of cyclic and acyclic ethers with acid chlorides in the presence of catalytic amounts of Bi(NO₃)₃·5H₂O under solvent-free conditions yielded the corresponding chloroesters. Also, the catalyst can be recovered conveniently and reused efficiently for at least six times.Key words: Bismuth(III) nitrate pentahydrate, cyclic and acyclic ethers, chloroesters.

  本文介绍了一种简便、高效的氯酯合成方法。在无溶剂条件下，环状和非环状醚与酸性氯化物在催化量 Bi(NO3)3-5H2O 的存在下发生反应，生成相应的氯酯。此外，催化剂可以方便地回收并有效地重复使用至少六次：五水硝酸铋（III） 环醚和无环醚 氯酯
• Synthesis of Vicinal Dichlorides via Activation of Aliphatic Terminal Epoxides with Triphosgene and Pyridine
  作者：Alexander H. Cleveland、Frank R. Fronczek、Rendy Kartika

  DOI：10.1021/acs.joc.7b03197

  日期：2018.3.16

  Herein we report a novel synthetic reaction to convert unactivated terminal aliphatic epoxide to alkyl vicinal dichloride based on triphosgene–pyridine activation. Our methodology is operationally simple and readily tolerated by a broad of scope of substrates as well as protecting groups. Furthermore, these mild conditions generally yield clean reaction mixtures that are free of byproducts upon aqueous

  在本文中，我们报道了一种基于三光气-吡啶活化将未活化的末端脂肪族环氧化物转化为烷基邻二氯乙烷的新型合成反应。我们的方法操作简单，容易被广泛的底物和保护基团所容忍。此外，这些温和的条件通常产生干净的反应混合物，该混合物在含水后处理时不含副产物。
• Combining AlCl3·6H2O and an ionic liquid to prepare chlorohydrin esters from glycerol
  作者：Gemma Villorbina、Albert Tomàs、Marc Escribà、Mireia Oromí-Farrús、Jordi Eras、Mercè Balcells、Ramon Canela

  DOI：10.1016/j.tetlet.2009.03.183

  日期：2009.6

  We describe here the first example in which glycerol has been transformed into chlorohydrin esters using an ionic liquid and hydrated aluminium chloride. The method avoids using Crown-18 ether, which was needed to obtain a similar yield when KCl was used. Alkyl and aryl acids can be used, although yields are very dependent on the carboxylic acid used.

  我们在这里描述第一个例子，其中使用离子液体和水合氯化铝将甘油转化为氯醇酯。该方法避免了使用Crown-18醚，而使用KCl时需要使用Crown-18醚才能获得相似的收率。可以使用烷基和芳基酸，尽管产率非常取决于所用的羧酸。