1-chloro-3-(2-methoxyphenyl)-2-propanol | 6859-53-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-chloro-3-(2-methoxyphenyl)-2-propanol
• 英文别名: 1-chloro-3-(2-methoxy-phenyl)-propan-2-ol；1-Chlor-3-(2-methoxy-phenyl)-propan-2-ol；(+/-)-2-Methoxy-1-(3-chlor-2-hydroxy-propyl)-benzol；(+/-)-3-Chlor-2-hydroxy-1-(2-methoxy-phenyl)-propan；1-Chloro-3-(2-methoxyphenyl)propan-2-ol
• CAS: 6859-53-6
• 化学式: C₁₀H₁₃ClO₂
• 分子量: 200.665
• InChiKey: YLWMOTAVTBVYKO-UHFFFAOYSA-N

物化性质

• 沸点：
  183 °C(Press: 15 Torr)
• 密度：
  1.202 g/cm3(Temp: 7 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-chloro-3-(2-methoxyphenyl)-2-propanol 在 盐酸 、 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 4-(o-Methoxy-phenyl)-3-hydroxy-buttersaeure
  参考文献：
  名称：

  4-（对-联苯甲酰基）-3-羟基丁酸及相关化合物的合成及抗炎活性。

  摘要：

  DOI：

  10.1021/jm00312a008
• 作为产物：
  描述：

  2-烯丙基苯甲醚 在 次氯酸 作用下， 生成 1-chloro-3-(2-methoxyphenyl)-2-propanol
  参考文献：
  名称：

  Normant, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1944, vol. 219, p. 163

  摘要：

  DOI：

文献信息

• Substituted heteroaryl amide modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof
  申请人：Sheppeck James

  公开号：US20060154973A1

  公开（公告）日：2006-07-13

  The present invention relates to new class of non-steroidal compounds which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory- and immune-associated diseases, and have the structure including all stereoisomers thereof, tautomers thereof, or a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein X is selected from N, O, and S; Y is N or CR 6 ; Z is a ring; and where R, R a , R b , R c , R d , R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

  本发明涉及一类新的非甾体化合物，用于治疗与糖皮质激素受体、AP-1和/或NF-κB活性调节相关的疾病，包括肥胖、糖尿病、炎症和免疫相关疾病，并具有结构，包括其所有立体异构体、互变异构体或前药，或其药用可接受盐，其中X选自N、O和S；Y为N或CR6；Z为一个环；R、Ra、Rb、Rc、Rd、R1、R2、R3、R4和R5如本文所定义。还提供了包含所述化合物的药物组合物和治疗肥胖、糖尿病以及炎症或免疫相关疾病的方法。
• New morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity
  申请人：Bentley Mark Jonathan

  公开号：US20060178510A1

  公开（公告）日：2006-08-10

  The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.

  本发明涉及化合物式(I)的化学化合物，以及其药学上可接受的盐和酯，其中R1至R5具有权利要求1中给出的含义。这些化合物可用于制备药物。
• Regioselective ring-opening of epoxides with ortho-lithioanisoles catalyzed by BF3·OEt2
  作者：Erkan Ertürk、Mustafa A. Tezeren、Taner Atalar、Tahir Tilki

  DOI：10.1016/j.tet.2012.05.116

  日期：2012.8

  It is presented that a number of o-2-hydroxyalkylanisoles could be efficiently synthesized through the regioselective ring-opening reaction of epoxides with o-lithioanisoles in the presence of BF3 center dot OEt2 Lewis-acid catalyst. Sterically demanding o-lithioanisoles had to be generated by exploiting the combination of (BuLi)-Bu-n and a catalytic amount of TMEDA (0.20 equiv) in Et2O as the lithiator whereas 'normal' anisole could be lithiated at ortho-position by treatment with (BuLi)-Bu-n in THE as usual. Surprisingly, the availability of THE and a catalytic amount of TMEDA (0.20 equiv) in the reaction mixture was found to enhance the reaction yields dramatically. A complex aggregate formation by the co-operative ligation of THF and TMEDA to ortho-lithioanisole(s) was proposed to rationalize the high reactivity achieved in the ring-opening reaction of epoxides. (C) 2012 Elsevier Ltd. All rights reserved.
• Beasley et al., Journal of Pharmacy and Pharmacology, 1959, vol. 11, p. 36,41
  作者：Beasley et al.

  DOI：——

  日期：——
• Alkoxyphenyl N-Substituted Aminopropanols
  作者：Elias Epstein

  DOI：10.1021/ja01532a025

  日期：1959.12