N-{4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)phenyl]thiophen-2-ylmethyl}-N-methylbenzamide | 814255-81-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)phenyl]thiophen-2-ylmethyl}-N-methylbenzamide
• 英文别名: N-[[4-[4-[(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenyl]thiophen-2-yl]methyl]-N-methylbenzamide
• CAS: 814255-81-7
• 化学式: C₂₃H₁₈N₂O₃S₂
• 分子量: 434.54
• InChiKey: PZVNMPWGJCOUFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  120
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-{4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)phenyl]thiophen-2-ylmethyl}-N-methylbenzamide 在 钯 氢气 、 钯 、 silica 、 methanol-dichloromethane 作用下， 以 1,4-二氧六环 为溶剂， 50.0 ℃ 、40.53 MPa 条件下， 反应 6.0h， 以1.5 g (75%) of N-{4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenyl]thiophen-2-ylmethyl}N-methylbenzamide are obtained in the form of a solid with a melting point of 134° C.的产率得到N-{4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenyl]thiophen-2-ylmethyl}-N-methylbenzamide
  参考文献：
  名称：

  Compounds that modulate PPAR gamma-type receptors and cosmetic/pharmaceutical compositions comprising said compounds

  摘要：

  具有以下一般式（I）的新化合物在人类或兽医学中有广泛的应用（在皮肤病学、心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域），或者被制成化妆品配方中。

  公开号：

  US20100247468A1
• 作为产物：
  描述：

  2,4-噻唑烷二酮 、 N-[4-(4-formylphenyl)thiophen-2-ylmethyl]-N-methylbenzamide 在 哌啶乙酸盐 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以78%的产率得到N-{4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)phenyl]thiophen-2-ylmethyl}-N-methylbenzamide
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS THAT MODULATE PPARgamma TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  [FR] NOUVEAUX COMPOSES QUI MODULENT LES RECEPTEURS DE TYPE PPAR DOLLAR G(G) ET UTILISATIONS DE CEUX-CI DANS DES COMPOSITIONS COSMETIQUES OU PHARMACEUTIQUES

  摘要：

  该发明涉及与下列一般式（I）相对应的新化合物：（I），以及用于制备它们的方法，以及它们在用于人类或兽医药物组合物中的用途（在皮肤病学以及心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域），或者在化妆品组合物中的用途。

  公开号：

  WO2004113331A1

文献信息

• Novel compounds that modulate PPARy type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Clary Laurence

  公开号：US20060148862A1

  公开（公告）日：2006-07-06

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下一般式（I）的新化合物在人类或兽医学中具有广泛的应用（在皮肤病学中，以及在心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域），或者被制成化妆品组合物。
• METHODS OF MODULATING PPAR GAMMA-TYPE RECEPTORS
  申请人：CLARY Laurence

  公开号：US20100099689A1

  公开（公告）日：2010-04-22

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下一般式（I）的新化合物在人类或兽医学中具有广泛的应用（在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域），或者被制成化妆品组合物。
• Compounds that modulate PPARγ-type receptors and cosmetic/pharmaceutical compositions comprising said compounds
  申请人：Galderma Research & Development

  公开号：US07968560B2

  公开（公告）日：2011-06-28

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下通式（I）的新化合物在人类或兽医学中的广泛应用中具有用途（在皮肤科，以及心血管疾病，免疫疾病和/或与脂质代谢有关的领域），或者，可以制成化妆品组合物。
• Compounds that modulate PPAR gamma-type receptors and cosmetic/pharmaceutical compositions comprising said compounds
  申请人：Clary Laurence

  公开号：US20100247468A1

  公开（公告）日：2010-09-30

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下一般式（I）的新化合物在人类或兽医学中有广泛的应用（在皮肤病学、心血管疾病、免疫疾病和/或与脂质代谢有关的疾病领域），或者被制成化妆品配方中。
• Compounds that modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Galderma Research & Development

  公开号：US07625914B2

  公开（公告）日：2009-12-01

  Novel compounds having the general formula (I) below: are useful in a wide variety of applications in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively are formulated into cosmetic compositions.

  具有以下一般式（I）的新化合物：在人类或兽医学中广泛应用（在皮肤科，以及心血管疾病，免疫疾病和/或与脂质代谢有关的疾病领域），或者被制成化妆品组合物。