allyl 3-mercaptopropionate | 61551-80-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: allyl 3-mercaptopropionate
• 英文别名: Prop-2-en-1-yl 3-sulfanylpropanoate；prop-2-enyl 3-sulfanylpropanoate
• CAS: 61551-80-2
• 化学式: C₆H₁₀O₂S
• 分子量: 146.21
• InChiKey: XARAYAUMHDGVKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  27.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NEW ARYL-BENZOCYCLOALKYL AMIDE DERIVATIVES
  申请人：Aebi Johannes

  公开号：US20130018055A1

  公开（公告）日：2013-01-17

  The invention provides novel compounds having the general formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , A 1 , A 2 and n are as described herein, compositions including the compounds and methods of using the compounds.

  该发明提供了具有一般式(I)的新化合物，其中R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、A1、A2和n如本文所述，包括该化合物的组合物以及使用该化合物的方法。
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：KIM SE-HO

  公开号：US20130053406A1

  公开（公告）日：2013-02-28

  The invention provides novel therapeutic compounds, pharmaceutical compositions comprising these compounds, and methods for using these compounds and compositions to treat diseases and disorders such as cancer.

  这项发明提供了新型治疗化合物，包括这些化合物的药物组合物，以及使用这些化合物和组合物治疗癌症等疾病和紊乱的方法。
• Use of Mercapto-Methyl Esters as Chain Transfer Agents
  申请人：ARKEMA FRANCE

  公开号：US20140235807A1

  公开（公告）日：2014-08-21

  Disclosed herein is a chain transfer agent in a free-radical emulsion polymerization process, of at least one mercapto-methyl ester, and also relates to the free-radical emulsion (co)polymerization process comprising at least one such mercapto-methyl ester and uses thereof. Also disclosed herein are mercapto-methyl diesters.

  本文披露了一种自由基乳液聚合过程中的链转移剂，至少包括一种巯基甲酯，并且涉及至少一种这样的巯基甲酯的自由基乳液（共）聚合过程及其用途。本文还披露了巯基甲酯二元酯。
• Process for the preparation of 2-penem compounds
  申请人：SCHERING CORPORATION

  公开号：EP0058317A1

  公开（公告）日：1982-08-25

  in which R1 is hydrogen, lower alkyl, acylamino, wherein R4 is hydrogen, lower alkyl, aryl or heteroaryl, R5 is hydrogen or an hydroxy protecting group, and R8 is halogen, , -SR9 (wherein R9 is lower alkyl, hydrogen or an -S protecting group), or the group in which one of R10 and R11 is an -N protecting group and the other is chosen from hydrogen, lower alkyl, aryl, aralkyl and acyl, or R10 and R11 are independently chosen from hydrogen, lower alkyl, aralkyl, aryl and acyl with the proviso that when one is hydrogen the other is acyl, R2 is lower alkyl, aryl, aralkyl, aminoalkyl, N-protected amino alkyl, hydroxyalkyl, O-protected hydroxyalkyl, thioalkyl, thioaryl, thioheteroaryl, an optionally esterfied a-amino acid residue, an optionally esterfied a-(N protected) amino acid residue or an optionally esterfied alkylcarboxy group; R3 is nitrile, tetrazolyl, or -COOR6 wherein R6 is hydrogen, the radical C(Hal)3 -Alk in which Hal is halogen and Alk represents an alkylene radical, lower alkyl, aryl, an allylic group, a metabolisable ester group, or a carboxy protecting group; X and Z are independently sulfur, oxygen, the radical =NR7 in which R7 is hydrogen, acyl, lower alkyl; aryl, or an N-protecting group, or -(CH2)n- in which n is 1 or 2; subject to the following provisos: (i) Z and X cannot simultaneously be(̵CH2)̵n in which n is 1 or 2; (ii) when X is S, Z is O or =NR7; (iii) when X is O, Z is O, S or =NR7; (iv) when X is -CH2-, Z is =NR7; except that when R7 is H or lower alkyl and R2 is lower alkyl then R1 cannot be acylamino; (v) when X is (̵CH2)̵2, Z is =NR7; and the pharmaceutically acceptable salts. Compounds of formula 1 are antibacterial agents which can be incorporated into pharmaceutical compositions or used as intermediates in the preparation of such agents.

  其中 R1 是氢、低级烷基、酰氨基、 其中 R4 是氢、低级烷基、芳基或杂芳基，R5 是氢或羟基保护基团，R8 是卤素、-SR9（其中 R9 是低级烷基、氢或-S 保护基团），或基团 其中 R10 和 R11 中的一个是-N 保护基团，另一个选自氢、低级烷基、芳基、烷基和酰基，或 R10 和 R11 独立选自氢、低级烷基、烷基、芳基和酰基，但其中一个为氢时，另一个为酰基、 R2 是低级烷基、芳基、芳烷基、氨基烷基、N 保护氨基烷基、羟基烷基、O 保护羟基烷基、硫代烷基、硫代芳基、硫代杂芳基、任选酯化的 a-氨基酸残基、任选酯化的 a-（N 保护）氨基酸残基或任选酯化的烷基羧基； R3 是腈、四唑基或-COOR6，其中 R6 是氢、自由基 C(Hal)3 -Alk （其中 Hal 是卤素，Alk 代表亚烷基、低级烷基、芳基、烯丙基、可代谢酯基或羧基保护基）； X 和 Z 独立地是硫、氧、自由基 =NR7（其中 R7 是氢、酰基、低级烷基、芳基或 N 保护基团）或-(CH2)n-（其中 n 是 1 或 2）；但书如下： (i) Z 和 X 不能同时为(̵ )̵n，其中 n 为 1 或 2； (ii) 当 X 为 S 时，Z 为 O 或 =NR7 (iii) 当 X 为 O 时，Z 为 O、S 或 =NR7 (iv) 当 X 为- -时，Z 为 =NR7；但当 R7 为 H 或低级烷基且 R2 为低级烷基时，R1 不能为酰氨基； (v) 当 X 为 (̵ )̵2 时，Z 为 =NR7； 以及药学上可接受的盐类。式 1 的化合物是抗菌剂，可掺入药物组合物中或用作制备此类药物的中间体。
• New method for the synthesis of 5-thio-1,2,3-thiadiazole
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0104403A1

  公开（公告）日：1984-04-04

  This disclosure describes a novel process for the synthesis of 5-mercapto-1,2,3-thiadiazoles which are useful as intermediates in the preparation of antibacterial agents.

  本公开介绍了一种合成 5-巯基-1,2,3-噻二唑的新工艺，该工艺可用作制备抗菌剂的中间体。