Tetradecatriin-(2.5.8)-ol-(1) | 35378-84-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Tetradecatriin-(2.5.8)-ol-(1)
• 英文别名: Tetradeca-2,5,8-triin-1-ol；1-hydroxy-2,5,8-tetradecatriyne；tetradeca-2,5,8-triyn-1-ol
• CAS: 35378-84-8
• 化学式: C₁₄H₁₈O
• 分子量: 202.296
• InChiKey: PJJVUOIWULPJMG-UHFFFAOYSA-N

物化性质

• 熔点：
  27.5-29.5 °C
• 沸点：
  137-138 °C(Press: 0.06 Torr)
• 密度：
  0.977±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Tetradecatriin-(2.5.8)-ol-(1) 在 吡啶 、 三溴化磷 作用下， 以 乙醚 为溶剂， 生成 docosa-4c,7c,10c,13c,16c-pentaenoic acid methyl ester
  参考文献：
  名称：

  Osbond,J.M. et al., Journal of the Chemical Society, 1961, p. 2783 - 2787

  摘要：

  DOI：
• 作为产物：
  描述：

  1-溴-2辛炔 在 吡啶 、 三溴化磷 作用下， 以 乙醚 为溶剂， 反应 3.0h， 生成 Tetradecatriin-(2.5.8)-ol-(1)
  参考文献：
  名称：

  Osbond,J.M. et al., Journal of the Chemical Society, 1961, p. 2783 - 2787

  摘要：

  DOI：

文献信息

• In situ alcohol oxidation-Wittig reactions using N-methoxy-N-methyl-2-(triphenylphosphoranylidine)acetamide: application to the synthesis of a novel analogue of 5-oxo-eicosatetraenoic acid
  作者：Leonie Blackburn、Hisashi Kanno、Richard J.K. Taylor

  DOI：10.1016/s0040-4039(02)02498-x

  日期：2003.1

  Benzylic, allylic, propargylic and unactivated alcohols can be oxidised with activated manganese dioxide in the presence of N-methoxy-N-methyl-2-(triphenylphosphoranylidine)acetamide to generate directly the corresponding α,β-unsaturated Weinreb amides. Elaboration of the resulting Weinreb amides is also described, in particular as part of a new route to analogues of the arachidonic acid metabolite

  可以在N-甲氧基-N-甲基-2-（三苯基膦基甲酰基）乙酰胺的存在下，用活化的二氧化锰将苯甲酸，烯丙基，炔丙基和未活化的醇氧化，以直接生成相应的α，β-不饱和Weinreb酰胺。还描述了所得Weinreb酰胺的制备，特别是作为花生四烯酸代谢物5-氧代-6 E，8 Z，11 Z，14 Z-二十碳四烯酸类似物的新途径的一部分。
• Sulphur-containing eicosanoides and their application in pharmacy and in
  申请人：Centre International de Recherches Dermatologiques C.I.R.D.

  公开号：US05268494A1

  公开（公告）日：1993-12-07

  Compounds corresponding to the formula: ##STR1## wherein A represents --CH.sub.2).sub.2 or --C.tbd.C--; n is equal to 0, 1 or 2; R represents hydroxyl, alkoxy having the formula --OR.sub.1, or amino having the formula ##STR2## R.sub.1 represents alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl; R.sub.2 and R.sub.3 represent hydrogen, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl or benzyl; R.sub.2 and R.sub.3 form, with the nitrogen atom, a heterocyclic ring. Application of these compounds in pharmacy and cosmetics.

  对应于以下公式的化合物：##STR1## 其中A代表--CH₂)₂或--C≡C--; n等于0、1或2; R代表羟基、具有公式--OR₁的烷氧基或具有公式##STR2##的氨基; R₁代表烷基、单羟基烷基、多羟基烷基、芳基或芳烷基; R₂和R₃代表氢、烷基、单羟基烷基、多羟基烷基、芳基或苄基; R₂和R₃与氮原子一起形成杂环环。这些化合物在制药和化妆品领域的应用。
• Eicosatetraynoic acid amides and their application in pharmacy
  申请人：Centre International de Recherches Dermatologioues C.I.R.D.

  公开号：US04916136A1

  公开（公告）日：1990-04-10

  Compound, characterized in that it corresponds to the formula: C.sub.5 H.sub.11 (C.tbd.C--CH.sub.2).sub.4 --CH.sub.2 CH.sub.2 CO R (I) in which R is an amino group of structure ##STR1## in which R.sub.1 and R.sub.2, which may be identical or different, denote a hydrogen atom or a linear or branches C.sub.1 -C.sub.8 lower alkyl radical substituted with at least one hydroxyl group, it being possible for this C.sub.1 -C.sub.8 lower alkyl radical to be interrupted by one or more hetero atoms chosen from oxygen, nitrogen or sulphur, R.sub.1 and R.sub.2 not simultaneously denoting a hydrogen atom and it being possible for R.sub.1 and R.sub.2 to form, with the nitrogen atom to which they are attached, a heterocycle containing one or more nitrogen, oxygen or sulphur atoms as an additional hetero atom, it being possible for this heterocycle to be optionally substituted with an alkyl or a hydroxyalkyl, and it also being possible for the amino group to be derived from a sugar, and their salts with inorganic or organic acids. These compounds are used, in particular, in the treatment and prophylaxis of allergic conditions and in the treatment of dermatoses and inflammatory conditions.

  该化合物的化学式为：C.sub.5 H.sub.11 (C.tbd.C--CH.sub.2).sub.4 --CH.sub.2 CH.sub.2 CO R (I)，其中R是结构为##STR1##的氨基基团，其中R.sub.1和R.sub.2可以相同也可以不同，表示氢原子或线性或支链C.sub.1-C.sub.8低级烷基基团，该基团至少取代有一个羟基，这个C.sub.1-C.sub.8低级烷基基团可以被来自氧、氮或硫的一个或多个杂原子所中断，R.sub.1和R.sub.2不能同时表示氢原子，R.sub.1和R.sub.2可以与它们所连接的氮原子形成一个杂环，该杂环含有一个或多个氮、氧或硫原子作为额外的杂原子，该杂环可以被选修地取代为烷基或羟基烷基，该氨基基团也可以来自于糖，并且它们与无机或有机酸的盐被用于特别是治疗和预防过敏症和治疗皮肤病和炎症状况。
• (poly)thiaalkynoic compounds and pharmaceutical/cosmetic compositions comprised thereof
  申请人：Societe L'Oreal S.A.

  公开号：US06511670B1

  公开（公告）日：2003-01-28

  Novel pharmaceutically/cosmetically-active (poly)thiaalkynoic compounds have the structural formula (I): R1—Y—CH2—C≡C—CH2—S—CH2—R2  (I) and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example inflammation disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

  具有药用/化妆品活性的新型聚硫炔烃化合物具有结构式（I）：R1—Y—CH2—C≡C—CH2—S—CH2—R2  （I），可用于治疗各种疾病状态，无论是人类还是兽医，例如炎症性疾病，以及哺乳动物皮肤和毛发状况/疾病的治疗。
• Lapitskaya; Vasiljeva; Pivnitsky, Synthesis, 1993, # 1, p. 65 - 66
  作者：Lapitskaya、Vasiljeva、Pivnitsky

  DOI：——

  日期：——