(Z)-3-cyclohexylbut-2-en-1-ol | 74896-75-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-3-cyclohexylbut-2-en-1-ol
• 英文别名: 3-Cyclohexyl-2-butenoic acid；(Z)-3-cyclohexylbut-2-enoic acid
• CAS: 74896-75-6
• 化学式: C₁₀H₁₆O₂
• 分子量: 168.236
• InChiKey: WVRIPRILKKOIQL-FPLPWBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  ethyl 3-cyclohexylbut-2-enoate 在 二异丁基氢化铝 、 水 、 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 (Z)-3-cyclohexylbut-2-en-1-ol 、 (E)-3-cyclohexylbut-2-enoic acid
  参考文献：
  名称：

  简单烯烃的对映选择性分子内醛 α-烷基化：直接获得同烯产品

  摘要：

  通过对映选择性 SOMO 催化，实现了一种从未活化的醛-烯烃前体合成不对称取代的碳环和杂环的高选择性方法。在悬垂烯烃上添加催化生成的烯胺自由基阳离子有助于建立一般的不对称策略，以产生广泛的具有烯烃转位的甲酰基取代的环。从概念上讲，这种新颖的机制允许直接访问“均烯”型产品。

  DOI：

  10.1021/ja4047312

文献信息

• [EN] BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS DE BENZIMIDAZOLE UTILES EN TANT QUE MODULATEURS DU RÉCEPTEUR TRP M8
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010132247A1

  公开（公告）日：2010-11-18

  The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8 (transient receptor potential M8 channel). More particularly, the compounds of the present invention are useful in the treatment of inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold, anxiety and depression.

  本发明涉及苯并咪唑衍生物，含有它们的药物组合物以及它们在治疗由TRP M8（瞬时受体电位M8通道）调节的疾病和症状中的应用。更具体地说，本发明的化合物在治疗炎症性疼痛、炎症性过敏症、炎症性过敏性疾病、神经病性疼痛、神经性寒冷触痛、炎症性体感过敏症、炎症性内脏过敏症、受寒加重的心血管疾病、焦虑和抑郁方面具有用处。
• Hydride reduction of alpha, beta-unsaturated carbonyl compounds using chiral organic catalysts
  申请人：MacMillan David

  公开号：US20060161024A1

  公开（公告）日：2006-07-20

  Nonmetallic, chiral organic catalysts are used to catalyze the 1,4-hydride reduction of an α,β-unsaturated carbonyl compound. The α,β-unsaturated carbonyl compound may be an aldehyde or cyclic ketone, and the hydride donor may be a dihydropyridine. The reaction is enantioselective, and proceeds with a variety of hydride donors, catalysts, and substrates. The invention also provides compositions effective in carrying out the 1,4-hydride addition of α,β-unsaturated carbonyl compounds.

  非金属手性有机催化剂被用于催化α，β-不饱和羰基化合物的1,4-氢化物还原。α，β-不饱和羰基化合物可以是醛或环酮，氢化物供体可以是二氢吡啶。该反应是对映选择性的，并且可以使用多种氢化物供体、催化剂和底物进行。该发明还提供了用于进行α，β-不饱和羰基化合物的1,4-氢化物加成的有效组合物。
• Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems
  申请人：——

  公开号：US20030125563A1

  公开（公告）日：2003-07-03

  One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, the transition metal catalyst consists essentially of copper and an asymmetric bidentate bisphosphine ligand.

  本发明的一个方面涉及过渡金属催化的手性1,4-加成方法，用于将亲核试剂（例如氢化物）加成到环状和非环状烯酸酯和烯酮上。在本发明的某些实施方式中，过渡金属催化剂基本上由铜和手性双膦配体组成。
• BENZIMIDAZOLE DERIVATIVES USEFUL AS TRP M8 RECEPTOR MODULATORS
  申请人：Calvo Raul R.

  公开号：US20100292276A1

  公开（公告）日：2010-11-18

  The present invention is directed to benzimidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8 (transient receptor potential M8 channel). More particularly, the compounds of the present invention are useful in the treatment of inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold, anxiety and depression.

  本发明涉及苯并咪唑衍生物、含有它们的制药组合物以及它们在TRP M8（瞬时受体电位M8通道）调节的疾病和症状治疗中的应用。更具体地说，本发明的化合物在治疗炎性疼痛、炎性过敏症、炎性过敏性疾病、神经病理性疼痛、神经性冷痛觉过敏、炎性体表过敏症、炎性内脏过敏症、寒冷加重的心血管疾病、焦虑和抑郁方面具有用途。
• Ethylene alpha-olefin polymer substituted Mannich base lubricant dispersant additives
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0356010A1

  公开（公告）日：1990-02-28

  The present invention is directed to oil-soluble lubricating oil additives comprising Mannich Base condensates of an alkyl substituted hydroxy aromatic compound with formaldehyde and an amine, wherein the alkyl-moiety of the aromatic compounds is derived from at least one ethylene alpha-olefin copolymer of 300 to 10,000 number average molecular weight, wherein at least about 30% of the polymer's chains contain terminal ethenylidene unsaturation. The Mannich Base condensates of this invention are useful as dispersants.

  本发明涉及油溶性润滑油添加剂，包括烷基取代的羟基芳香化合物与甲醛和胺的曼尼希碱缩合物，其中芳香化合物的烷基分子来自至少一种平均分子量为 300 至 10,000 的乙烯-α-烯烃共聚物，其中至少约 30% 的聚合物链含有末端乙烯不饱和。本发明的曼尼希碱缩合物可用作分散剂。