5,5a(2)-Ethenylidenebis[1-[(4-methoxyphenyl)methyl]-1H-pyrazole] | 173730-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5,5a(2)-Ethenylidenebis[1-[(4-methoxyphenyl)methyl]-1H-pyrazole]
• 英文别名: 1-[(4-methoxyphenyl)methyl]-5-[1-[2-[(4-methoxyphenyl)methyl]pyrazol-3-yl]ethenyl]pyrazole
• CAS: 173730-28-4
• 化学式: C₂₄H₂₄N₄O₂
• 分子量: 400.48
• InChiKey: RKRKBWCVFJHSPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  54.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲基三苯基溴化膦 、 Bis-[2-(4-methoxy-benzyl)-2H-pyrazol-3-yl]-methanone 在 正丁基锂 作用下， 生成 5,5a(2)-Ethenylidenebis[1-[(4-methoxyphenyl)methyl]-1H-pyrazole]
  参考文献：
  名称：

  An Unusual dependency of counterion during wittig methylenation of bis-heteroaryl ketones

  摘要：

  Attempted Wittig methylenation of some bis-heteroaromatic ketones (8, 11 and 13) using MeP(+)Ph(3)Br and n-BuLi gave none of the desired olefin. However, when KtBuO was used as the base for generation of the ylide, efficient olefination of these ketones was observed. A possible mechanistic pathway for this interesting but unprecedented observation is proposed.

  DOI：

  10.1016/0040-4039(95)02016-i

文献信息

• Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts and compositionsand methods of use thereof
  申请人：STERLING WINTHROP INC.

  公开号：EP0656359A1

  公开（公告）日：1995-06-07

  Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts of Formula, pharmaceutical compositions containing them, and methods for the treatment or prevention of neurodegenerative disorders or neurotoxic injuries utilizing them.

  式中的取代的 6,11-乙hano-6,11-二氢苯并[b]喹嗪盐、 含有它们的药物组合物，以及利用它们治疗或预防神经退行性疾病或神经毒性损伤的方法。
• US5554620A
  申请人：——

  公开号：US5554620A

  公开（公告）日：1996-09-10
• US5631264A
  申请人：——

  公开号：US5631264A

  公开（公告）日：1997-05-20
• An Unusual dependency of counterion during wittig methylenation of bis-heteroaryl ketones
  作者：Chakrapani Subramanyam

  DOI：10.1016/0040-4039(95)02016-i

  日期：1995.12

  Attempted Wittig methylenation of some bis-heteroaromatic ketones (8, 11 and 13) using MeP(+)Ph(3)Br and n-BuLi gave none of the desired olefin. However, when KtBuO was used as the base for generation of the ylide, efficient olefination of these ketones was observed. A possible mechanistic pathway for this interesting but unprecedented observation is proposed.