ethyl 4-(2-(1-ethoxy-1,3-dioxobutan-2-ylidene)hydrazinyl)benzoate | 34582-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 4-(2-(1-ethoxy-1,3-dioxobutan-2-ylidene)hydrazinyl)benzoate
• 英文别名: ethyl 4-((1-ethoxy-1,3-dioxobutan-2-yl) hydrazono)benzoate；AHE-13；ethyl 4-[2-(1-ethoxy-1,3-dioxobutan-2-ylidene)hydrazinyl]benzoate
• CAS: 34582-85-9
• 化学式: C₁₅H₁₈N₂O₅
• 分子量: 306.318
• InChiKey: HXVZLMIWVJXPTC-UHFFFAOYSA-N

物化性质

• 沸点：
  423.2±47.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.78
• 重原子数：
  22.0
• 可旋转键数：
  7.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  94.06
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  (2,4-dinitro-phenyl)-acetic acid hydrazide 、 ethyl 4-(2-(1-ethoxy-1,3-dioxobutan-2-ylidene)hydrazinyl)benzoate 在 溶剂黄146 作用下， 生成 4-{N'-[1-[2-(2,4-Dinitro-phenyl)-acetyl]-3-methyl-5-oxo-1,5-dihydro-pyrazol-(4E)-ylidene]-hydrazino}-benzoic acid ethyl ester
  参考文献：
  名称：

  Misra, V. S.; Chaudhary, Chapla; Agarwal, Rajesh, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, # 5, p. 466 - 467

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酰乙酸乙酯 、 苯佐卡因 在 盐酸 、 sodium nitrite 、 sodium acetate 作用下， 以 水 、 乙醇 为溶剂， 以81%的产率得到ethyl 4-(2-(1-ethoxy-1,3-dioxobutan-2-ylidene)hydrazinyl)benzoate
  参考文献：
  名称：

  Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictus

  摘要：

  A novel series of aryl hydrazono esters (AHE) (1-13) were synthesized (yield 76-98%) to study the oviposition responses in Aedes albopictus (Skuse) mosquitoes for the first time. At a concentration of 10 mu g ml(-1) in dual choice experiment, among the screened compounds, AHE-12 showed remarkable oviposition attractant activity with an oviposition activity index (OAI) of +0.299 (greater than 95% confidence limit) comparable to p-cresol (OAI +0.320) which is well-reported oviposition attractant for Aedes aegypti. Conversely, AHE-10 exhibited highest oviposition deterrent activity with OAI -0.247. The possible utilization of these compounds will be in integrated vector management strategies. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.11.101

文献信息

• Amir, Mohd; Agarwal, Rajesh, Journal of the Indian Chemical Society, 1997, vol. 74, # 2, p. 154 - 155
  作者：Amir, Mohd、Agarwal, Rajesh

  DOI：——

  日期：——
• Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictus
  作者：Prabal Bandyopadhyay、Lopamudra Guha、T. Seenivasagan、Manisha Sathe、Pratibha Sharma、B.D. Parashar、M.P. Kaushik

  DOI：10.1016/j.bmcl.2010.11.101

  日期：2011.1

  A novel series of aryl hydrazono esters (AHE) (1-13) were synthesized (yield 76-98%) to study the oviposition responses in Aedes albopictus (Skuse) mosquitoes for the first time. At a concentration of 10 mu g ml(-1) in dual choice experiment, among the screened compounds, AHE-12 showed remarkable oviposition attractant activity with an oviposition activity index (OAI) of +0.299 (greater than 95% confidence limit) comparable to p-cresol (OAI +0.320) which is well-reported oviposition attractant for Aedes aegypti. Conversely, AHE-10 exhibited highest oviposition deterrent activity with OAI -0.247. The possible utilization of these compounds will be in integrated vector management strategies. (C) 2010 Elsevier Ltd. All rights reserved.
• Misra, V. S.; Chaudhary, Chapla; Agarwal, Rajesh, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, # 5, p. 466 - 467
  作者：Misra, V. S.、Chaudhary, Chapla、Agarwal, Rajesh

  DOI：——

  日期：——