difluoromethyl sulfonium ylide | 507-12-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: difluoromethyl sulfonium ylide
• 英文别名: difluoromethyl mercaptan；difluoromethyl-sulfane；difluoromethylsulfide；difluoromethanethiol；difluoromethylthiol
• CAS: 507-12-0
• 化学式: CH₂F₂S
• 分子量: 84.0897
• InChiKey: KLJYQOSMCTZTGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  difluoromethyl sulfonium ylide 、 [2-(2,6-Dichloro-4-trifluoromethylphenyl)-2H-1,2,3-triazol-4-yl]methyl methanesulfonate 以 乙腈 为溶剂， 反应 72.0h， 以56%的产率得到2-(2,6-dichloro-4-trifluoro-methylphenyl)-4-[(difluoromethylthio)methyl]2H-1,2,3-triazole
  参考文献：
  名称：

  The Synthesis and Insecticidal Activity of a Series of 2‐Aryl‐1,2,3‐triazoles

  摘要：

  Two synthetic routes to 2-aryl-1,2,3-triazoles are outlined. These have been used to synthesise a wide range of compounds of this structural type. Their insecticidal activities were evaluated against a number of veterinary and public health pests. The activity of these compounds is especially good against the housefly (Musca domestica). Structure-activity relationships are discussed particularly in relation to the physical properties of the compounds.

  DOI：

  10.1002/(sici)1096-9063(199610)48:2<189::aid-ps461>3.0.co;2-#
• 作为产物：
  描述：

  Thioacetic acid S-difluoromethyl ester 生成 difluoromethyl sulfonium ylide
  参考文献：
  名称：

  The Synthesis and Insecticidal Activity of a Series of 2‐Aryl‐1,2,3‐triazoles

  摘要：

  Two synthetic routes to 2-aryl-1,2,3-triazoles are outlined. These have been used to synthesise a wide range of compounds of this structural type. Their insecticidal activities were evaluated against a number of veterinary and public health pests. The activity of these compounds is especially good against the housefly (Musca domestica). Structure-activity relationships are discussed particularly in relation to the physical properties of the compounds.

  DOI：

  10.1002/(sici)1096-9063(199610)48:2<189::aid-ps461>3.0.co;2-#

文献信息

• Synthesis and Antibacterial Activity of Novel 4-Pyrrolidinylthio Carbapenems II:2-Alkyl and 2-Arylthiomethyl Derivatives.
  作者：HIDENORI AZAMI、KEIJI MATSUDA、HIDEO TSUTSUMI、TOSHIAKI KAMIMURA、MASAYOSHI MURATA

  DOI：10.7164/antibiotics.51.374

  日期：——
• The Synthesis and Insecticidal Activity of a Series of 2‐Aryl‐1,2,3‐triazoles
  作者：Ian K. Boddy、Geoff G. Briggs、Richard P. Harrison、Tim H. Jones、Mary J. O'Mahony、Ian D. Marlow、Brian G. Roberts、R. John Willis、Richard Bardsley、Jim Reid

  DOI：10.1002/(sici)1096-9063(199610)48:2<189::aid-ps461>3.0.co;2-#

  日期：1996.10

  Two synthetic routes to 2-aryl-1,2,3-triazoles are outlined. These have been used to synthesise a wide range of compounds of this structural type. Their insecticidal activities were evaluated against a number of veterinary and public health pests. The activity of these compounds is especially good against the housefly (Musca domestica). Structure-activity relationships are discussed particularly in relation to the physical properties of the compounds.