1,3-Diaminoindan | 26976-66-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1,3-Diaminoindan
• 英文别名: cis 1,3-diaminoindan；2,3-dihydro-1H-indene-1,3-diamine
• CAS: 26976-66-9
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: CLTXLGPSIXHRDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,3-indandione dioxime 在 sodium 作用下， 以 乙醇 、 水 为溶剂， 生成 1,3-Diaminoindan
  参考文献：
  名称：

  US5646188

  摘要：

  公开号：

文献信息

• DIAMINOPROPANE DERIVED MACROCYCLES AS INHIBITORS OF BETA AMYLOID PRODUCTION
  申请人：Marcin Lawrence R.

  公开号：US20080194535A1

  公开（公告）日：2008-08-14

  There is provided a series of macrocyclic diaminopropanes of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , m, n, W, X, Y, Z and L as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

  提供一系列宏环脂肪二胺丙烷化合物的化学式（I）或其立体异构体；或其药用盐， 其中R1，R2，R3，m，n，W，X，Y，Z和L如本文所定义，它们的药物组合物和使用方法。这些新化合物抑制β-分泌酶对淀粉样前体蛋白（APP）的加工，更具体地说，抑制Aβ-肽的产生。本公开涉及对治疗与β-淀粉样蛋白产生相关的神经系统疾病的化合物，如阿尔茨海默病和其他受抗淀粉样活性影响的疾病。
• LIGAND COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERAZATION, AND METHOD FOR OLEFIN OLIGOMERIZATION USING THE SAME
  申请人：LG CHEM, LTD.

  公开号：US20160122371A1

  公开（公告）日：2016-05-05

  This disclosure relates to a ligand compound, a catalyst system for olefin oligomerization, and a method for olefin oligomerization using the same. The catalyst system for olefin oligomerization according to the present invention has excellent catalytic activity, and yet, exhibits high selectivity to 1-hexene and 1-octene, thus enabling efficient preparation of alpha-olefin.

  本公开涉及一种配体化合物、用于烯烃寡聚的催化剂体系以及使用该催化剂体系的烯烃寡聚方法。根据本发明的烯烃寡聚催化剂体系具有优异的催化活性，同时对1-己烯和1-辛烯具有高选择性，因此能够有效制备α-烯烃。
• Polyamine derivatives of 1-aminoindan
  申请人：Teva Pharmaceutical Industries, Ltd.

  公开号：US05646188A1

  公开（公告）日：1997-07-08

  A compound of general formula I ##STR1## wherein n is 1 or 2; R.sub.1 and R.sub.2 are each independently hydrogen, hydroxy, substituted or unsubstituted C.sub.1-4 alkyl, substituted or unsubstituted C.sub.1-4 alkoxy or halogeno; R.sub.5 is hydrogen, substituted or unsubstituted C.sub.1-4 alkyl, amino or NR.sub.6 R.sub.7 ; R.sub.3, R.sub.4, R.sub.6 and R.sub.7 are each independently hydrogen or (CH.sub.2).sub.m --[NH(CH.sub.2).sub.x ].sub.y --NHR.sub.11 wherein m is from 0-5, y is from 0-5 and each x is independently from 1-5 and R.sub.11 is hydrogen or C(NH)NH.sub.2 ; provided that when R.sub.3 and R.sub.4 are both hydrogen, R.sub.5 is amino or NR.sub.6 R.sub.7 ; pharmaceutically acceptable salts and optically active isomers thereof.

  通式为I的化合物：##STR1## 其中n为1或2；R.sub.1和R.sub.2各自独立地为氢、羟基、取代或未取代的C.sub.1-4烷基、取代或未取代的C.sub.1-4烷氧基或卤素基；R.sub.5为氢、取代或未取代的C.sub.1-4烷基、氨基或NR.sub.6R.sub.7；R.sub.3、R.sub.4、R.sub.6和R.sub.7各自独立地为氢或(CH.sub.2).sub.m--[NH(CH.sub.2).sub.x].sub.y--NHR.sub.11，其中m为0-5，y为0-5，每个x独立地为1-5，R.sub.11为氢或C(NH)NH.sub.2；但当R.sub.3和R.sub.4都为氢时，R.sub.5为氨基或NR.sub.6R.sub.7；其药学上可接受的盐和光学异构体。
• LIGAND COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION, AND OLEFIN OLIGOMERIZATION METHOD USING SAME
  申请人：LG Chem, Ltd.

  公开号：EP2987783A1

  公开（公告）日：2016-02-24

  This disclosure relates to a ligand compound, a catalyst system for olefin oligomerization, and a method for olefin oligomerization using the same. The catalyst system for olefin oligomerization according to the present invention has excellent catalytic activity, and yet, exhibits high selectivity to 1-hexene and 1-octene, thus enabling efficient preparation of alpha-olefin.

  本发明涉及一种配体化合物、一种用于烯烃低聚的催化剂体系，以及使用该催化剂体系进行烯烃低聚的方法。本发明的烯烃低聚催化剂体系具有优异的催化活性，而且对 1-己烯和 1-辛烯具有高选择性，从而能够高效制备α-烯烃。
• EP0865276A4
  申请人：——

  公开号：EP0865276A4

  公开（公告）日：2003-07-30