2-amino-6-(4-chloroanilino)purine | 120045-92-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-amino-6-(4-chloroanilino)purine
• 英文别名: 2-amino-6-p-chloroanilinepurine；2-amino-6-p-chloroanilinopurine；N~6~-(4-chlorophenyl)-7H-purine-2,6-diamine；6-N-(4-chlorophenyl)-7H-purine-2,6-diamine
• CAS: 120045-92-3
• 化学式: C₁₁H₉ClN₆
• 分子量: 260.686
• InChiKey: NTKUSIHPGLXJHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.5
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-acetamido-9-acetyl-6-chloropurine 在 水 、 三乙胺 、 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.3h， 生成 2-amino-6-(4-chloroanilino)purine
  参考文献：
  名称：

  Microwave assisted synthesis of 2,6-substituted aromatic-aminopurine derivatives

  摘要：

  AbstractA series of novel 2, 6‐diaromatic‐aminopurines (6a–6t) have been synthesized from guanine and characterized fully. The effects of different catalysts on the N‐alkylation of 2‐position of purine ring were discussed. J. Heterocyclic Chem., (2011).

  DOI：

  10.1002/jhet.629

文献信息

• Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK)
  申请人：CHEN Han-Min

  公开号：US20140303112A1

  公开（公告）日：2014-10-09

  The present invention relates to a method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are useful to activate AMP-activated protein kinase (AMPK) and the use of the compounds in the prevention or treatment of disease, including pre-diabetes, type 2 diabetes, syndrome X, metabolic syndrome and obesity.

  本发明涉及一种治疗疾病或病情的方法，该疾病或病情容易通过AMPK激活剂和公式化合物得到改善，这些化合物有助于激活AMP激活蛋白激酶（AMPK），并将这些化合物用于预防或治疗疾病，包括糖尿病前期、2型糖尿病、X综合症、代谢综合征和肥胖症。
• Yakout, El-Sayed M. A.; Soe, Henrik M.; Pedersen, Erik B., Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1988, vol. 42, # 4, p. 257 - 258
  作者：Yakout, El-Sayed M. A.、Soe, Henrik M.、Pedersen, Erik B.

  DOI：——

  日期：——
• YAKOUT, EL SAUED M. A.;SZHUSTOOL, HENRIK M.;REDERSEN, ERIK V., ACTA CHEM. SCAND., 42,(1988) N 4, 257-258
  作者：YAKOUT, EL SAUED M. A.、SZHUSTOOL, HENRIK M.、REDERSEN, ERIK V.

  DOI：——

  日期：——
• US9938279B2
  申请人：——

  公开号：US9938279B2

  公开（公告）日：2018-04-10
• Microwave assisted synthesis of 2,6-substituted aromatic-aminopurine derivatives
  作者：Hong-Fei Lu、Liang-Ze Zhang、Ding-Ming Wu、Jun-Tao Zhou

  DOI：10.1002/jhet.629

  日期：2011.9

  AbstractA series of novel 2, 6‐diaromatic‐aminopurines (6a–6t) have been synthesized from guanine and characterized fully. The effects of different catalysts on the N‐alkylation of 2‐position of purine ring were discussed. J. Heterocyclic Chem., (2011).