Visible Light-Induced Methoxycarbonyldifluoromethylation of Trimethylsilyl Enol Ethers and Allyltrimethylsilanes with FSO<sub>2</sub>
CF<sub>2</sub>
CO<sub>2</sub>
Me
作者:Wei Yu、Yao Ouyang、Xiu-Hua Xu、Feng-Ling Qing
DOI:10.1002/cjoc.201800318
日期:2018.11
omethylation of trimethylsilyl enol ethers with FSO2CF2CO2Me in the presence of fac‐Ir(ppy)3 was developed. This reaction provided a practical strategy for the construction of various α‐CF2CO2R aromatic ketones, which are difficult to access by other methods. Furthermore, a series of methoxycarbonyldifluoromethylated allylic compounds could also be obtained from allyltrimethylsilanes using the same
在fac -Ir(ppy)3存在下,用FSO 2 CF 2 CO 2 Me对三甲基甲硅烷基烯醇醚进行了光催化甲氧基羰基二氟甲基化反应。该反应的各种α-CF的构造提供了一种实用的策略2 CO 2 - [R芳族酮,这是难以通过其它方法获得。此外,也可以使用相同策略从烯丙基三甲基硅烷获得一系列甲氧基羰基二氟甲基化的烯丙基化合物。所得的含CF 2 CO 2 R的产品是有用的组成部分,在药物化学和材料科学中具有潜在的价值。
A Highly Enantioselective Hydrogenation of Silyl Enol Ethers Catalyzed by Chiral Frustrated Lewis Pairs
作者:Simin Wei、Haifeng Du
DOI:10.1021/ja507536n
日期:2014.9.3
Using a simple combination of tri-tert-butylphosphine and chiral borane generated in situ by the hydroboration of chiral diene with HB(C6F5)2 as a frustratedLewis pair catalyst, a highly enantioselective metal-freehydrogenation of silyl enol ethers was successfully realized to furnish a variety of optically active secondary alcohols in 93-99% yields with 88->99% ee's.
通过手性二烯与 HB(C6F5)2 的硼氢化反应原位生成的三叔丁基膦和手性硼烷的简单组合作为受挫的路易斯对催化剂,成功实现了甲硅烷基烯醇醚的高对映选择性无金属氢化以 93-99% 的收率提供各种光学活性仲醇,其中 ee 为 88->99%。
α-Arylation of Silyl Enol Ethers via Rhodium(III)-Catalyzed C–H Functionalization
作者:Xuezhen Kou、Kevin G. M. Kou
DOI:10.1021/acscatal.9b05622
日期:2020.3.6
Carbon–hydrogen (C–H) bond functionalization streamlines synthesis by increasing step- and atom-economies. This approach, catalyzed by Rh(III), is combined with the α-arylation of ketone-derived silyl enol ethers to achieve a direct cross-coupling event. The advancement of electron-rich alkenes as substrates is enabled through the use of a silver additive and complements existing C–H activation methods
Synthese von 4,4-Bis(trifluormethyl)-1-oxabuta-1,3-dienen
作者:Klaus Burger、Brigitte Helmreich
DOI:10.1002/prac.19923340304
日期:——
Silyl enol ethers (1) and hexafluoroacetone (2) react to give O-silylated aldol adducts 3 which, after desilylation with methanol/hydrochloric acid, are transformed into 4.4-bis(trifluoromethyl)-1-oxabuta-1,3-dienes (5) on treatment with trifluoroacetic acid anhydride/pyridine.
Shipov, A. G.; Baukov, Yu. I., Journal of general chemistry of the USSR, 1986, p. 111 - 122