5-(5-methyl-5-methoxycarbonyl-<1,2,4>trioxolan-3-yl)pentanoic acid | 189575-21-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(5-methyl-5-methoxycarbonyl-<1,2,4>trioxolan-3-yl)pentanoic acid
• 英文别名: 5-(5-Methoxycarbonyl-5-methyl-1,2,4-trioxolan-3-yl)pentanoic acid
• CAS: 189575-21-1
• 化学式: C₁₀H₁₆O₇
• 分子量: 248.233
• InChiKey: LQABEHAFZLICKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-(5-methyl-5-methoxycarbonyl-<1,2,4>trioxolan-3-yl)pentanoic acid 在 盐酸 、 三乙胺 作用下， 生成 己二酸
  参考文献：
  名称：

  Syntheses of bifunctional compounds from cycloalkenes via ozonide intermediates

  摘要：

  The ozonolytic cleavage of cycloalkene in the presence of methyl pyruvate affords a tri-substituted ozonide. The resulted tri-substituted ozonide moiety contained three reactive centers (i.e. peroxide, ozonide ring proton and methoxycarbonyl group) which could be transformed to different functional groups under different conditions in good yields. It is a very efficient and versatile methodology to prepare the terminal differentiated compounds from symmetric cycloalkenes in two steps in high yields. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00207-x
• 作为产物：
  描述：

  丙酮酸甲酯 、 环己烯 在 臭氧 作用下， 以 二氯甲烷 为溶剂， 以64%的产率得到5-(5-methyl-5-methoxycarbonyl-<1,2,4>trioxolan-3-yl)pentanoic acid
  参考文献：
  名称：

  The ozonolytic cleavage of cycloalkenes in the presence of methyl pyruvate to yield the terminally differentiated compounds

  摘要：

  DOI：

  10.1016/0040-4039(93)88113-w

文献信息

• Syntheses of bifunctional compounds from cycloalkenes via ozonide intermediates
  作者：Yung-Son Hon、Jiann-Long Yan

  DOI：10.1016/s0040-4020(97)00207-x

  日期：1997.4

  The ozonolytic cleavage of cycloalkene in the presence of methyl pyruvate affords a tri-substituted ozonide. The resulted tri-substituted ozonide moiety contained three reactive centers (i.e. peroxide, ozonide ring proton and methoxycarbonyl group) which could be transformed to different functional groups under different conditions in good yields. It is a very efficient and versatile methodology to prepare the terminal differentiated compounds from symmetric cycloalkenes in two steps in high yields. (C) 1997 Elsevier Science Ltd.
• The ozonolytic cleavage of cycloalkenes in the presence of methyl pyruvate to yield the terminally differentiated compounds
  作者：Hon Yung-Son、Yanb Sann-Long

  DOI：10.1016/0040-4039(93)88113-w

  日期：1993.10