Guaifenesin di-tms derivative | 107966-19-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Guaifenesin di-tms derivative
• 英文别名: [1-(2-methoxyphenoxy)-3-trimethylsilyloxypropan-2-yl]oxy-trimethylsilane
• CAS: 107966-19-8
• 化学式: C₁₆H₃₀O₄Si₂
• 分子量: 342.583
• InChiKey: KLADZOREYXDLAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.15
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  愈创甘油醚 、 六甲基二硅氮烷 在 C₁₂H₂₄KO₆*I₃^(1-) 作用下， 以 二氯甲烷 为溶剂， 反应 0.67h， 以100%的产率得到Guaifenesin di-tms derivative
  参考文献：
  名称：

  A new crystal engineering approach for the synthesis of {[K.18-Crown-6]I3}n as a nanotube-Like and recyclable catalyst for the chemoselective silylation of alcohols

  摘要：

  Reaction of 18-crown-6 with KI in ethanol solution followed by addition of iodine (I-2) afforded a unique triiodide salt with a nanotube-like structure ({[K.18-Crown-6]I-3}(n)). It is shown that this reagent may be used for the chemoselective trimethylsilylation of alcohols. The synthesis of the crystalline reagent is a good example of crystal engineering. Reagent was recycled and reused.

  DOI：

  10.1007/bf03249082

文献信息

• A new crystal engineering approach for the synthesis of {[K.18-Crown-6]I3}n as a nanotube-Like and recyclable catalyst for the chemoselective silylation of alcohols
  作者：M. A. Zolfigol、E. Kolvari、N. Koukabi、S. Salehzadeh、G. Chehardoli、I. S. Tidmarsh、K. Niknam

  DOI：10.1007/bf03249082

  日期：2011.6

  Reaction of 18-crown-6 with KI in ethanol solution followed by addition of iodine (I-2) afforded a unique triiodide salt with a nanotube-like structure ([K.18-Crown-6]I-3}(n)). It is shown that this reagent may be used for the chemoselective trimethylsilylation of alcohols. The synthesis of the crystalline reagent is a good example of crystal engineering. Reagent was recycled and reused.