1-hydroxy-azepane-2,7-dione | 35356-89-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-hydroxy-azepane-2,7-dione
• 英文别名: N-hydroxyadipimide；1-Hydroxyazepane-2,7-dione
• CAS: 35356-89-9
• 化学式: C₆H₉NO₃
• 分子量: 143.142
• InChiKey: ALFSJUJGXLTALQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  己二酸 在 羟胺 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 6.0h， 以5.4%的产率得到1-hydroxy-azepane-2,7-dione
  参考文献：
  名称：

  EP1757583

  摘要：

  公开号：

文献信息

• [EN] PEPTIDE-CONJUGATED PRODRUGS<br/>[FR] PROMÉDICAMENTS CONJUGUÉS À UN PEPTIDE
  申请人：UNIV BRANDEIS

  公开号：WO2021055690A1

  公开（公告）日：2021-03-25

  The present disclosure relates to a conjugated prodrug comprising a peptide conjugated to an antibiotic molecules via a cleavable linker and pharmaceutical compositions thereof. Also disclosed are methods of enhancing the intracellular concentration of an antibiotic agent in a bacterium and methods of treating a patient for a bacterial infection.

  本公开涉及一种共轭前药，包括通过可切割连接物将肽与抗生素分子结合在一起的药物，并其制药组合物。还公开了增强细菌内抗生素药物浓度的方法以及治疗患有细菌感染的患者的方法。
• PROCESS FOR PRODUCING CYCLIC N-HYDROXYIMIDE COMPOUND
  申请人：DAICEL CHEMICAL INDUSTRIES, LTD.

  公开号：EP1757583A1

  公开（公告）日：2007-02-28

  A cyclic polycarboxylic acid anhydride, a polycarboxylic acid, or a mixture of them is allowed to react with hydroxylamine or a salt thereof in an organic solvent under dewatering conditions to yield a corresponding cyclic N-hydroxyimide compound. The cyclic polycarboxylic acid anhydride can be, for example, succinic anhydride or glutaric anhydride. The polycarboxylic acid can be, for example, succinic acid, glutaric acid, or adipic acid. In this process, the reaction is preferably carried out using an organic solvent capable of undergoing azeotropy with water as all or part of a reaction solvent while removing water from the reaction system by azeotropy with the organic solvent. This process produces a cyclic N-hydroxyimide compound in a good yield from any of a cyclic polycarboxylic acid anhydride and a polycarboxylic acid.

  在脱水条件下，让环状聚羧酸酐、聚羧酸或它们的混合物在有机溶剂中与羟胺或其盐反应，生成相应的环状 N-羟基亚胺化合物。例如，环状聚羧酸酐可以是琥珀酸酐或戊二酸酐。聚羧酸可以是琥珀酸、戊二酸或己二酸等。在此过程中，反应最好使用能够与水共沸的有机溶剂作为全部或部分反应溶剂，同时通过与有机溶剂共沸从反应体系中除去水分。该工艺可从环状聚羧酸酐和聚羧酸中的任何一种以良好的收率制得环状 N-羟基亚胺化合物。
• Process for producing cyclic n-hydroxy imide compounds
  申请人：Kajikawa Yasuteru

  公开号：US20070197798A1

  公开（公告）日：2007-08-23

  A cyclic polycarboxylic acid anhydride, a polycarboxylic acid, or a mixture of them is allowed to react with hydroxylamine or a salt thereof in an organic solvent under dewatering conditions to yield a corresponding cyclic N-hydroxyimide compound. The cyclic polycarboxylic acid anhydride can be, for example, succinic anhydride or glutaric anhydride. The polycarboxylic acid can be, for example, succinic acid, glutaric acid, or adipic acid. In this process, the reaction is preferably carried out using an organic solvent capable of undergoing azeotropy with water as all or part of a reaction solvent while removing water from the reaction system by azeotropy with the organic solvent. This process produces a cyclic N-hydroxyimide compound in a good yield from any of a cyclic polycarboxylic acid anhydride and a polycarboxylic acid.
• PROCESS FOR PRODUCING CYCLIC N-HYDROXY IMIDE COMPOUNDS
  申请人：KAJIKAWA Yasuteru

  公开号：US20090286993A1

  公开（公告）日：2009-11-19

  A cyclic polycarboxylic acid anhydride, a polycarboxylic acid, or a mixture of them is allowed to react with hydroxylamine or a salt thereof in an organic solvent under dewatering conditions to yield a corresponding cyclic N-hydroxyimide compound. The cyclic polycarboxylic acid anhydride can be, for example, succinic anhydride or glutaric anhydride. The polycarboxylic acid can be, for example, succinic acid, glutaric acid, or adipic acid. In this process, the reaction is preferably carried out using an organic solvent capable of undergoing azeotropy with water as all or part of a reaction solvent while removing water from the reaction system by azeotropy with the organic solvent. This process produces a cyclic N-hydroxyimide compound in a good yield from any of a cyclic polycarboxylic acid anhydride and a polycarboxylic acid.
• PEPTIDE-CONJUGATED PRODRUGS
  申请人：BRANDEIS UNIVERSITY

  公开号：US20220387610A1

  公开（公告）日：2022-12-08

  The present disclosure relates to a conjugated prodrug comprising a peptide conjugated to an antibiotic molecules via a cleavable linker and pharmaceutical compositions thereof. Also disclosed are methods of enhancing the intracellular concentration of an antibiotic agent in a bacterium and methods of treating a patient for a bacterial infection.