5-(5-羧基吡啶-3-基)苯-1,3-二羧酸 | 1261960-45-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-(5-羧基吡啶-3-基)苯-1,3-二羧酸
• 英文名称: 5-(3',5'-dicarboxylphenyl)nicotinic acid
• 英文别名: 5-(5-carboxypyridin-3-yl)isophthalic acid；5-(5-Carboxypyridin-3-yl)benzene-1,3-dicarboxylic acid
• CAS: 1261960-45-5
• 化学式: C₁₄H₉NO₆
• 分子量: 287.229
• InChiKey: GMPJSOVKZWZUOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  cobalt(II) chloride hexahydrate 、 5-(5-羧基吡啶-3-基)苯-1,3-二羧酸 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 72.5h， 以78%的产率得到
  参考文献：
  名称：

  Simultaneous Trapping of C ₂ H ₂ and C ₂ H ₆ from a Ternary Mixture of C ₂ H ₂ /C ₂ H ₄ /C ₂ H ₆ in a Robust Metal–Organic Framework for the Purification of C ₂ H ₄

  摘要：

  AbstractThe removal of C2H2 and C2H6 from C2H4 streams is of great significance for feedstock purification to produce polyethylene and other commodity chemicals but the simultaneous adsorption of C2H6 and C2H2 over C2H4 from a ternary mixture has never been realized. Herein, a robust metal–organic framework, TJT‐100, was designed and synthesized, which demonstrates remarkably selective adsorption of C2H2 and C2H6 over C2H4. Breakthrough experiments show that TJT‐100 can be used as an adsorbent for high‐performance purification of C2H4 from a ternary mixture of C2H2/C2H4/C2H6 (0.5:99:0.5) to afford a C2H4 purity greater than 99.997 %, beyond that required for ethylene polymerization. Computational studies reveal that the uncoordinated carboxylate oxygen atoms and coordinated water molecules pointing towards the pore can trap C2H2 and C2H6 through the formation of multiple C−H⋅⋅⋅O electrostatic interactions, while the corresponding C2H4–framework interaction is unfavorable.

  DOI：

  10.1002/anie.201809884

文献信息

• Indium–Organic Frameworks Based on Dual Secondary Building Units Featuring Halogen-Decorated Channels for Highly Effective CO₂ Fixation
  作者：Yang Yuan、Jiantang Li、Xiaodong Sun、Guanghua Li、Yunling Liu、Gaurav Verma、Shengqian Ma

  DOI：10.1021/acs.chemmater.8b04792

  日期：2019.2.12

  Accordingly, the three nanochannel MOF catalysts exhibited highly effective performances in catalyzing cycloaddition of CO2 with large-sized epoxides, particularly styrene oxide, into value-added products—styrene carbonates with yields of 91–93% and high selectivity of 95–98%—under mild conditions. We speculated that the superior catalytic efficiencies of the three MOF catalysts could be ascribed to the synergistic

  利用“双功能配体导向策略”，成功地构建了具有针对性结构的基于双重二级建筑单元（SBU）的三个同构铟有机框架。在他们的框架中，两种类型的不饱和单体铟S​​BU-[In（OOC-）2（-N-）X（H 2 O）]和[In（OOC-）2（-N-）X 2 ] -（X = Cl，Br和I）-组装形成一维管状通道，同时具有开放的金属位点和弱碱极化取代基。三聚铟SBU [In 3 O（OOC-）6（DMA）3 ] +用作强大的外部链接器，以扩展为具有纳米级通道的3D蜂窝双壁框架。通过用不同的卤素改变原位偏振取代基（氯- ，溴-和I - ），三点获得同构的MOF显示不同的信道特性，例如作为偏振取代基时，极化开放铟站点的酸度，扩展的通道尺寸的碱度，并增加了孔体积（从-I到-Cl）。随后，我们以三个MOF为平台，研究了不同配位卤离子对通道功能（尤其是对CO 2）的影响。吸附和化学转化。因此，三种纳米通道MOF催化剂在催化CO
• RETRACTED: Two new Cu(II) coordination polymer nanostructures induce human oral squamous cell carcinoma apoptotic cell death in vitro and in vivo
  作者：Fengdi Cao、Chuanliang Shu、Beibei Ni、Zhenhua Gao

  DOI：10.1016/j.molstruc.2019.127142

  日期：2020.1

  Abstract In this contribution, we characterized and synthesized two three-dimensional Cu(II) involving coordination polymers [Cu(L1)](H2O)1}n (1·H2O) and [Cu4Li(L2)2(μ3-OH)2(H2O)2](NO3)(H2O)(DMA)2}n (2, DMA = N,N-dimethylacetamide) along with their nanoparticles based on two pyridine-carboxylate ligands 5-(3′,5′-dicarboxylphenyl)nicotic acid (H3L2) as well as 3,3’-(pyridine-3,5-diyl)dibenzoic acid

  摘要 在这一贡献中，我们表征并合成了两种涉及配位聚合物 [Cu(L1)](H2O)1}n (1·H2O) 和 [Cu4Li(L2)2(μ3-OH )2(H2O)2](NO3)(H2O)(DMA)2}n (2, DMA = N,N-二甲基乙酰胺) 及其基于两个吡啶羧酸配体 5-(3',5'-二羧基苯基)烟酸 (H3L2) 以及 3,3'-(pyridine-3,5-diyl) 二苯甲酸 (H2L1) 通过利用溶剂热和声化学方法。此外，我们报道了纳米粒子 1-2（以下表示为 1 NPs 和 2 NPs）在体内和体外治疗人类癌症中的重要作用。通过细胞计数试剂盒-8 (CCK8) 检测，我们确定了人口腔鳞状细胞癌细胞系 (HSC-4) 的细胞增殖和细胞活力。该结果表明，与纳米颗粒 2 相比，纳米颗粒 1 对 HSC-4 癌细胞显示出更高的抗癌活性。 活性氧检测和 Annexin V-FITC/PI
• Two metal–organic frameworks based on pyridyl–tricarboxylate ligands as size-selective catalysts for solvent-free cyanosilylation reaction
  作者：Yiwen Zhang、Kongzhao Su、Miao Hao、Lin Liu、Zheng-Bo Han、Daqiang Yuan

  DOI：10.1039/c8ce00694f

  日期：——

  Two new three-dimensional metal–organic frameworks [(CH3)2NH2]2[TM2(L)2]}n·x(solvent) (FJI-Y7, FJI = Fujian Institute, TM = Zn; FJI-Y8, TM = Cd) have been solvothermally prepared based on multifunctional pyridyl–tricarboxylate ligand 5-(5-carboxypyridin-3-yl)benzene-1,3-dicarboxylic acid (H3L). Single crystal X-ray analysis reveals that they possess non-interpenetrating binodal (4,4)-connected three-dimensional

  两个新的三维金属有机框架[（CH 3）2 NH 2 ] 2 [TM 2（L）2 ]} n · x（溶剂）（FJI-Y7，FJI =福建研究所，TM = Zn；FJI -Y8（TM = Cd）已基于多功能吡啶基-三羧酸酯配体5-（5-羧基吡啶-3--3-基）苯-1,3-二羧酸（H 3 L）进行溶剂热制备。单晶X射线分析表明，它们具有不互穿的双四面体（4,4）连接的三维PtS型网络，其Schläfli点符号为4 2 ·8 4}。有趣的是，FJI-Y7和FJI-Y8均可用作高效的尺寸选择非均相催化剂，用于在温和条件下进行乙醛的无溶剂氰基硅烷化反应。
• Proton conductivities of four low dimensional MOFs: affected by the amount of chelated ligands
  作者：Chuan-Cong Zhou、Hou-Ting Liu、Li Ding、Jing Lu、Su-Na Wang、Yun-Wu Li

  DOI：10.1039/d1ce00589h

  日期：——

  Hydrogen bonds, existing among water molecules and carboxyl groups, were discontinuous in compound 3. In the structure of compound 4, Ni(II) cations were linked to form a 2D layered structure. There was no phen ligand, more water molecules acted as the terminal ligands and were involved in the formation of continuous hydrogen bonds. The studies of proton conductivity showed that compounds 1 and 2 had

  四个低维 MOF，[Mn 3 (L) 2 (bipy) 2 ]} n ( 1 ), [Mn 3 (L) 2 (phen) 2 ]} n ( 2 ), [Co 3 (L) 2 (phen)(H 2 O) 8 ]·4H 2 O} n ( 3 ) 和[Ni 3 (L) 2 (H 2 O) 12 ]·4H 2 O} n ( 4 ) (H 3L = 5-(3',5'-二羧基苯基)烟酸；bipy = 2,2'-联吡啶；phen = 菲咯啉）已被合成和表征。对于化合物1和2，Mn( II )阳离子通过L 3-配体连接形成二维层状结构。它们的晶体结构包含高比例的双联或苯酚螯合配体，并且没有水分子或氢键。对于化合物3，金属阳离子连接形成一维配位链，苯酚的比例降低，一些作为末端配体的水分子占据了金属阳离子的部分配位位点。水分子和羧基之间存在的氢键在化合物3中是不连续的. 在化合物4的结构中，Ni( II
• A white-light-emitting lanthanide metal–organic framework for luminescence turn-off sensing of MnO₄⁻ and turn-on sensing of folic acid and construction of a “turn-on plus” system
  作者：Zhen-Peng Dong、Fei Zhao、Lei Zhang、Zhi-Liang Liu、Yan-Qin Wang

  DOI：10.1039/d0nj02145h

  日期：——

  A novel single-phase white-light-emitting microscale lanthanide metal–organic framework [Eu0.06Tb0.04Gd0.9(HDPNC)1.5(H2O)(DMF)]·2H2O (H3DPNC = 5-(3′,5′-dicarboxylphenyl) nicotinic acid) abbreviated as Eu0.06Tb0.04Gd0.9-DPNC was obtained successfully under 365 nm excitation, by adjusting the molar ratio of Ln3+ and different excitation wavelengths, with the Commission Internationale de l’Eclairage (CIE)

  一种新型的单相发白光微米级镧系金属-有机骨架[Eu 0.06 Tb 0.04 Gd 0.9（HDPNC）1.5（H 2 O）（DMF）]·2H 2 O（H 3 DPNC = 5-（3'通过在国际照明委员会（C委员会）中调整Ln 3+的摩尔比和不同的激发波长，在365 nm激发下成功获得了缩写为Eu 0.06 Tb 0.04 Gd 0.9 -DPNC的（5'-二羧基苯基）烟酸）CIE）坐标为（0.3328，0.3296）。三发射镧系金属有机骨架（Eu 0.06 Tb 0.04 Gd0.9 -DPNC），作为一种有效的荧光平台，不仅朝向的MnO显示出显着的荧光淬灭（关断） 4 -在水中通过荧光共振能量转移（FRET）机理，线性识别范围为0–0.2 mM，低检测限（LOD）为0.0197μM，而且还显示了荧光增强（开启），可检测叶酸通过宿主与客体之间的相互作用形成水中的脂肪酸（FA），浓度范围为0-18μM，LOD为0