(3'-methoxy[1,1'-biphenyl]-4-yl)(methyl)sulfane | 646505-59-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3'-methoxy[1,1'-biphenyl]-4-yl)(methyl)sulfane
• 英文别名: 1,1'-Biphenyl, 3-methoxy-4'-(methylthio)-；1-methoxy-3-(4-methylsulfanylphenyl)benzene
• CAS: 646505-59-1
• 化学式: C₁₄H₁₄OS
• 分子量: 230.331
• InChiKey: NSICTLPNNRZHMH-UHFFFAOYSA-N

物化性质

• 沸点：
  356.2±25.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  间甲氧基苯甲酰氯 在 bis-triphenylphosphine-palladium(II) chloride 、 碳酸氢钠 、 三乙胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基乙酰胺 、 甲苯 为溶剂， 反应 5.0h， 生成 (3'-methoxy[1,1'-biphenyl]-4-yl)(methyl)sulfane
  参考文献：
  名称：

  Palladium-Catalyzed Decarbonylative Suzuki–Miyaura Coupling of Amides To Achieve Biaryls via C–N Bond Cleavage

  摘要：

  The palladium-catalyzed decarbonylative Suzuki-Miyaura coupling of amides via selective amide C-N bond cleavage was reported, which afforded mild access to substitute biaryl products in the presence of low catalyst loading with NaHCO3 as the base in good yields within 4 h (29 examples).

  DOI：

  10.1021/acs.joc.9b01103

文献信息

• Palladium-Catalyzed Cross-CouplingReaction of Potassium Diaryldifluoroborates with Aryl Halides
  作者：Takatoshi Ito、Toshiyuki Iwai、Takumi Mizuno、Yoshio Ishino

  DOI：10.1055/s-2003-40851

  日期：——

  The catalytic cross-coupling reaction of potassium di­aryldifluoroborates with aryl halides proceeds to afford the biphenyls in good yields. These salts on an arylation reagent were readily prepared via a protocol of the Grignard method and transformation to potassium salts. Two aryl groups of these salts were efficiently transferred in the Suzuki-Miyaura reaction.

  钾二芳基二氟硼酸盐与芳烃卤化物的催化交叉耦合反应能够以良好的产率产生产酚。通过格氏试剂法及转化为钾盐的步骤，这些盐作为芳烃化试剂被容易制备。通过铃木-宫浦反应，这些盐的两个芳基高效转移。
• Palladium-Catalyzed Decarbonylative Suzuki–Miyaura Coupling of Amides To Achieve Biaryls via C–N Bond Cleavage
  作者：Zhongfeng Luo、Li Xiong、Tingting Liu、Yuqi Zhang、Siqi Lu、Yuwen Chen、Weijie Guo、Yulin Zhu、Zhuo Zeng

  DOI：10.1021/acs.joc.9b01103

  日期：2019.9.6

  The palladium-catalyzed decarbonylative Suzuki-Miyaura coupling of amides via selective amide C-N bond cleavage was reported, which afforded mild access to substitute biaryl products in the presence of low catalyst loading with NaHCO3 as the base in good yields within 4 h (29 examples).