5-(1-Methylethyl)-2-pyridinesulfonic acid | 180031-04-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 5-(1-Methylethyl)-2-pyridinesulfonic acid
• 英文别名: 5-propan-2-ylpyridine-2-sulfonic acid
• CAS: 180031-04-3
• 化学式: C₈H₁₁NO₃S
• 分子量: 201.25
• InChiKey: HXAZFIXWZPERHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NOVEL SULFONAMIDES<br/>[FR] NOUVEAUX SULFONAMIDES
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：WO1996019459A1

  公开（公告）日：1996-06-27

  (EN) Compounds of formula (I) wherein R1-R8, A and B have the significance given in the description, are endothelin inhibitors and can be used for the treatment of disorders which are associated with endothelin activities, such as high blood pressure.(FR) Des composés de formule (I), où R1-R8, A et B ont la notation donnée dans le descriptif, sont des inhibiteurs de l'endothéline et peuvent s'utiliser pour le traitement de troubles associés aux activités de l'endothéline, tels que l'hypertension artérielle.

  (中文) 公式（I）中R1-R8，A和B具有描述中给出的意义，是内皮素抑制剂，可用于治疗与内皮素活性相关的疾病，如高血压。
• [EN] 4-HETEROCYCLYSULFONAMIDYL-6-METHOXY-5-(2-METHOXY-PHENOXY)-2-PYRIDYL-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND USE AS ENDOTHELIN RECEPTOR ANTAGONISTS<br/>[FR] DERIVES 4-HETEROCYCLYSULFONAMIDYL-6-METHOXY-5-(2-METHOXY-PHENOXY)-2-PYRIDYL-PYRIMIDINE, PREPARATIONS ET UTILISATIONS COMME ANTAGONISTES DU RECEPTEUR D'ENDOTHELINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2000052007A1

  公开（公告）日：2000-09-08

  The compounds of formula (I) wherein R1 is a heterocyclic residue selected form pyridil and thiazolyl, where said heterocyclic residue may optionally be substituted with lower alkyl or lower alkenyl; and pharmaceutically acceptable salts thereof, are inhibitors of endothelin receptors and can therefore be used for the treatment of disorders which are associated with abnormal vascular tone and endothelial dysfunction; and the corresponding intermediates of formulae (III) and (V).

  化合物的化学式为（I），其中R1是从吡啶基和噻唑基中选择的杂环残基，所述杂环残基可以选择性地用较低的烷基或烯基取代；以及其药学上可接受的盐，是内皮素受体的抑制剂，因此可用于治疗与异常血管张力和内皮功能障碍相关的疾病；以及化学式（III）和（V）的相应中间体。
• Sulfonylamino-acetic acid derivatives
  申请人：Aissaoui Hamed

  公开号：US20060014783A1

  公开（公告）日：2006-01-19

  The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.

  本发明涉及一种新型磺酰氨基乙酸衍生物及其作为制备药物组合物中的活性成分的用途。本发明还涉及相关方面，包括制备这些化合物的过程，含有其中一种或多种化合物的药物组合物，特别是它们作为促进睡眠的药物和促进睡眠的药物。
• Heterocyclic sulfonamides
  申请人：——

  公开号：US20020137933A1

  公开（公告）日：2002-09-26

  The compounds of formula (I) 1 wherein R 1 has the significance as given in the description, are inhibitors of endothelin receptors and can therefore be used for the treatment of disorders which are associated with abnormal vascular tone and endothelial dysfunction.

  式(I)1中的化合物其中R1的含义如描述所述，是内皮素受体的抑制剂，因此可用于治疗与异常血管张力和内皮功能障碍有关的疾病。
• SULFONYLAMINO-ACETIC ACID DERIVATIVES
  申请人：Aissaoui Hamed

  公开号：US20070244156A1

  公开（公告）日：2007-10-18

  The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.

  本发明涉及新型磺酰氨基乙酸衍生物及其作为制备药物组成的活性成分的用途。本发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，特别是它们作为促进睡眠的药物的用途。