hippuric acid 2-phenylethyl ester | 1003863-63-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: hippuric acid 2-phenylethyl ester
• 英文别名: 2-Phenylethyl 2-benzamidoacetate；2-phenylethyl 2-benzamidoacetate
• CAS: 1003863-63-5
• 化学式: C₁₇H₁₇NO₃
• 分子量: 283.327
• InChiKey: POTGSKZAPHAICP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯基马尿酸 、 苯乙醇 在 tetrabutylammonium tricarbonylnitrosylferrate 4 A molecular sieve 作用下， 以 正己烷 为溶剂， 反应 24.0h， 以42%的产率得到hippuric acid 2-phenylethyl ester
  参考文献：
  名称：

  A Nucleophilic Fe Catalyst for Transesterifications under Neutral Conditions

  摘要：

  Carboxylic esters belong to the most important functional groups in organic chemistry. Strong efforts have been made in developing mild catalytic procedures for their preparation. Among the various methods developed to date, transesterifications have occupied an important space. In the present paper, a new catalytic method for this process based on the use of nucleophilic Fe(-II) complexes is presented. Evidence for the formation of an intermediate acyl Fe complex will be presented as well as investigations on scope and limitations.

  DOI：

  10.1021/ol702580a

文献信息

• Nucleophilic Iron Catalysis in Transesterifications: Scope and Limitations
  作者：Silja Magens、Bernd Plietker

  DOI：10.1021/jo1004636

  日期：2010.6.4

  The ester bond is one of the most common structural motifs found in nature. Apart from the condensation between an acid and an alcohol, transesterifications represent another mechanistic alternative for the preparation of this compound class. The present paper summarizes our most recent investigations in this field, using nucleophilic iron complexes as catalysts for transesterifications under neutral conditions. This new type of metal catalyst complements the existing methodologies, which rely on Lewis acidic metal complexes. Investigations on scope and limitations, stereochemical course, and chemoselectivities will be presented.
• A Nucleophilic Fe Catalyst for Transesterifications under Neutral Conditions
  作者：Silja Magens、Melanie Ertelt、Anja Jatsch、Bernd Plietker

  DOI：10.1021/ol702580a

  日期：2008.1.1

  Carboxylic esters belong to the most important functional groups in organic chemistry. Strong efforts have been made in developing mild catalytic procedures for their preparation. Among the various methods developed to date, transesterifications have occupied an important space. In the present paper, a new catalytic method for this process based on the use of nucleophilic Fe(-II) complexes is presented. Evidence for the formation of an intermediate acyl Fe complex will be presented as well as investigations on scope and limitations.