3-(p-vinylbenzylthio)propionic acid | 138895-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(p-vinylbenzylthio)propionic acid
• 英文别名: 3-[(4-ethenylphenyl)methylsulfanyl]propanoic acid
• CAS: 138895-40-6
• 化学式: C₁₂H₁₄O₂S
• 分子量: 222.308
• InChiKey: ATWQTFCCUCCPMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,6-二叔丁基-4-甲基苯酚 、 4-氯甲基苯乙烯 、 3-巯基丙酸 在 盐酸 、 氢氧化钾 作用下， 以 乙醚 、 乙醇 、 正己烷 、 二氯甲烷 为溶剂， 生成 3-(p-vinylbenzylthio)propionic acid
  参考文献：
  名称：

  Carboxy containing monomers

  摘要：

  某些具有反应性羧基的乙烯基不饱和可聚合单体对于制备用于多种用途的同聚物和共聚物是有用的，包括诊断分析。聚合物可以以乳胶粒的形式在水性配方中提供。这些单体由以下结构表示：##STR1## 其中：R是氢、卤素或1到3个碳原子的烷基，M是氢、碱金属离子或铵离子，L是一个连接基团，其连接链中有8到50个原子，并包含两个或多个二价烃基团，这些基团通过一个或多个氮、氧或硫原子连接或终止，或者通过连接链中含有一个或多个这样的原子的一个或多个基团，前提是L至少含有一个不是直接连接到端部##STR2##基团的芳基，并且进一步提供，没有任何烃基团具有非芳香不饱和度。

  公开号：

  US05210289A1

文献信息

• Carboxy containing monomers and polymers and latices prepared from same
  申请人：Eastman Kodak Company

  公开号：US05149737A1

  公开（公告）日：1992-09-22

  Certain ethylenically unsaturated polymerizable monomers having a reactive carboxy group are useful for preparing homo- and copolymers for a variety of uses, including diagnostic assays. The polymers can be supplied as latex particles in aqueous compositions. The monomers are represented by the structure: ##STR1## wherein: R is hydrogen, halo or alkyl or 1 to 3 carbon atoms, M is hydrogen, an alkali metal ion or an ammonium ion, and L is a linking group having from 8 to 50 atoms in its linking chain, and comprises two or more divalent hydrocarbon groups connected or terminated with one or more nitrogen, oxygen or sulfur atoms, or with one or more groups containing such atoms in the linking chain, provided L has at least one arylene which is not directly connected to the terminal ##STR2## and further provided that none of the hydrocarbon groups has non-aromatic unsaturation.

  具有反应性羧基的某些乙烯基不饱和可聚合单体可用于制备用于各种用途的同聚物和共聚物，包括诊断检测。聚合物可以作为水性组合物中的乳胶粒子提供。单体由以下结构表示：##STR1##其中：R为氢，卤素或1至3个碳原子的烷基，M为氢，碱金属离子或铵离子，L为具有8至50个原子的连接链中的连接基，并包括两个或多个二价碳氢基团连接或终止于一个或多个氮、氧或硫原子，或包含这样的原子的基团在连接链中，前提是L至少有一个芳基，该芳基未直接连接到末端##STR2##并且进一步提供，没有任何碳氢基团具有非芳香不饱和性。
• Immunoreagent composition, test kit and rapid assay for human chorionic gonadotropin
  申请人：CLINICAL DIAGNOSTIC SYSTEMS, INC.

  公开号：EP0456308A1

  公开（公告）日：1991-11-13

  A rapid immunometric assay for human chorionic gonadotropin (hCG), commonly used for detection of pregnancy in human females, has been developed using a specific wash solution and conjugate level which reduces background and improves sensitivity. The assay can be carried out within two minutes using a microporous membrane to capture the "sandwich" complex of antigen and two antibodies, one of which is located on the membrane. Greater sensitivity at low levels of hCG have been demonstrated so the assay is useful as an early indicator of pregnancy. An immunoreagent composition and test kit are provided for use in the assay.

  人类绒毛膜促性腺激素（hCG）通常用于检测人类女性是否怀孕，我们开发出了一种快速免疫测定法，该方法采用特定的洗涤液和共轭物水平，可降低本底，提高灵敏度。使用微孔膜捕获抗原和两种抗体的 "三明治 "复合物（其中一种抗体位于膜上），可在两分钟内完成检测。实验证明，当 hCG 含量较低时，检测灵敏度更高，因此该检测方法可作为怀孕的早期指标。我们提供了用于检测的免疫试剂组合物和检测试剂盒。
• Biologically active reagents prepared from carboxy-containing polymer, analytical element and methods of use
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0462644A1

  公开（公告）日：1991-12-27

  Biologically active reagents are prepared from particles of copolymers having highly reactive carboxy or equivalent groups. The reagents are prepared by covalently attaching biologically active substances, for example antibodies, to the particles, directly or indirectly through highly reactive carboxy groups on the particle surface. These reagents are used to advantage in analytical elements, methods for the detection of specific binding ligands (such as immunological species) and immunoassays, and in purification methods as affinity chromatography reagents.

  生物活性试剂由具有高活性羧基或等效基团的共聚物颗粒制备而成。制备试剂的方法是将生物活性物质（如抗体）直接或间接地通过颗粒表面的高活性羧基共价连接到颗粒上。这些试剂可用于分析元件、检测特定结合配体（如免疫物种）的方法和免疫测定，也可作为亲和层析试剂用于纯化方法。
• Test devices
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0478047A1

  公开（公告）日：1992-04-01

  In test devices used for polymerase chain reaction amplification of DNA, beads bearing reagents are used to attach to the DNA. However, in such test devices, the flow of liquid sample is through the layer of the beads. It is desirable in some test devices to have the flow of liquid sample past the bead layer. However, this has the disadvantage that a number of the beads may be washed away leaving an insufficient number to complete the test analysis. Described herein is a test device (10) comprising beads (80, 82, 84, 86) with a reagent attached, the beads being physically fused to a support (70). The support (70) comprises a material selected to have a melting temperature significantly lower than that of the beads (80, 82, 84, 86). Polyethylene is a preferred example of such a material.

  在用于 DNA 聚合酶链反应扩增的测试装置中，珠子上的试剂被用来附着在 DNA 上。然而，在这些测试装置中，液体样品的流动是通过珠子层的。在某些测试装置中，液体样品最好流过珠子层。但这样做的缺点是，一些珠子可能会被冲走，留下的珠子数量不足以完成测试分析。本文描述的是一种测试装置（10），包括附有试剂的珠子（80、82、84、86），珠子与支架（70）物理融合。支架（70）包括一种材料，该材料的熔化温度明显低于珠子（80、82、84、86）的熔化温度。聚乙烯是此类材料的首选。
• Wash composition containing signal stop reagent, test kit and method of use with peroxidase-labeled specific binding ligand
  申请人：Johnson & Johnson Clinical Diagnostics, Inc.

  公开号：EP0537825A1

  公开（公告）日：1993-04-21

  A buffered composition containing a nonionic or anionic surfactant, and a certain amount of a hydroxamic acid (or salt thereof) or an acyl hydrazine can be used as a wash composition in specific binding assays. Such assays include the use of a peroxidase labeled specific binding reactant to form a detectable peroxidase-labeled specific binding complex. The buffered composition and labeled reactant can be supplied in a diagnostic test kit. The hydroxamic acid or acyl hydrazine can be represented by the structure(I):         R-CO-NH-R' wherein R is aryl or 6 to 10 carbon atoms in the aromatic nucleus, alkyl of 1 to 7 carbon atoms, cycloalkyl of 5 to 10 carbon atoms in the ring, or heterocyclyl of 5 to 10 atoms in the ring, at least one of which is an oxygen, nitrogen or sulfur atom, and R' is hydroxy or amino.

  含有非离子或阴离子表面活性剂和一定量的羟肟酸（或其盐）或酰基肼的缓冲组合物可用作特异性结合试验中的洗涤组合物。此类检测包括使用过氧化物酶标记的特异性结合反应物，以形成可检测的过氧化物酶标记的特异性结合复合物。缓冲组合物和标记反应物可在诊断检测试剂盒中提供。羟肟酸或酰基肼可由结构(I)表示： R-CO-NH-R' 其中 R 是芳基或芳香核中 6 至 10 个碳原子的芳基、1 至 7 个碳原子的烷基、环中 5 至 10 个碳原子的环烷基或环中 5 至 10 个原子的杂环烷基，其中至少一个是氧、氮或硫原子，R'是羟基或氨基。