2-(methoxycarbonyl)-3-(tetradecyloxy)phenol | 130442-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(methoxycarbonyl)-3-(tetradecyloxy)phenol
• 英文别名: 3-tetradecyloxy-2-carbomethoxyphenol；Methyl 2-hydroxy-6-tetradecoxybenzoate
• CAS: 130442-13-6
• 化学式: C₂₂H₃₆O₄
• 分子量: 364.525
• InChiKey: YYVACOKHVQZSNI-UHFFFAOYSA-N

物化性质

• 沸点：
  465.0±25.0 °C(Predicted)
• 密度：
  1.000±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(methoxycarbonyl)-3-(tetradecyloxy)phenol 在 sodium acetate 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 反应 5.5h， 生成 3-(bromomethyl)phenyl 2-(methoxycarbonyl)-3-(tetradecyloxy)phenyl phosphoric acid diester
  参考文献：
  名称：

  Analogs of platelet activating factor. 6. Mono- and bis-aryl phosphate antagonists of platelet activating factor

  摘要：

  A series of aryl phosphoglyceride (3, 19-6 1) and bis-aryl phosphate (67-135) antagonists of platelet activating factor (PAF) were prepared. A group of four bifunctional phosphorus reagents (5a-c and 7) were developed that allowed the preparation of these aryl phosphates in which the position of aromatic substitution can be varied. These compounds were examined for their ability to inhibit PAF-induced platelet aggregation of rabbit platelets. Selected compounds were also evaluated for their ability to displace [H-3]PAF from its receptor on rabbit platelets. These in vitro data were compared to similar data obtained for a number of known PAF antagonists. The compounds were evaluated in vivo, in both the mouse and rabbit, for their ability to prevent death induced by a lethal challenge of PAF. The relationships between the biological activity and the nature, lipophilicity, and position of substituents of the aromatic rings were studied. Compound 105 (CL 184005) has been selected to undergo further development as a potential therapeutic agent for the treatment of septic shock in man.

  DOI：

  10.1021/jm00087a023
• 作为产物：
  描述：

  2,6-二羟基苯甲酸 在 硫酸 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成 2-(methoxycarbonyl)-3-(tetradecyloxy)phenol
  参考文献：
  名称：

  6-Oxa isosteres of anacardic acids as potent inhibitors of bacterial histidine protein kinase (HPK)-mediated two-component regulatory systems

  摘要：

  A series of 6-oxa isosteres of anacardic acids (6-higher alkkyl/alkenyl-2-hydroxybenzoic acids) was synthesised and several members were discovered to be among the most potent inhibitors (IC50 values less than or equal to 5 mu M) of the bacterial two-component regulatory systems, KinA/SpoOF and NRII/NRI, reported to date. The Gram-positive antibacterial activity in selected strains is also presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00508-9

文献信息

• Bis-arylphosphate ester antagonists of platelet activating factor
  申请人：American Cyanamid Co.

  公开号：US04983592A1

  公开（公告）日：1991-01-08

  The invention is novel compounds of the formula: ##STR1## which are antagonists of platelet activating factor.

  这项发明是一种新型化合物，化学式为：##STR1##，它们是血小板活化因子的拮抗剂。
• Novel bis-arylphosphate ester antagonists of platelet activating factor
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0374513A2

  公开（公告）日：1990-06-27

  The invention is novel compounds of the formula: which are antagonists of platelet activating factor.

  本发明是式中的新型化合物： 是血小板活化因子的拮抗剂。
• US4983592A
  申请人：——

  公开号：US4983592A

  公开（公告）日：1991-01-08
• US5147864A
  申请人：——

  公开号：US5147864A

  公开（公告）日：1992-09-15
• US5231091A
  申请人：——

  公开号：US5231091A

  公开（公告）日：1993-07-27