1-([1,2,4]Triazolo[1,5-a]pyrimidin-5-yl)ethanone | 869646-10-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: 1-([1,2,4]Triazolo[1,5-a]pyrimidin-5-yl)ethanone
• CAS: 869646-10-6
• 化学式: C₇H₆N₄O
• 分子量: 162.151
• InChiKey: HUCRFBBFBMNSBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-amino-5-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}benzaldehyde 、 1-([1,2,4]Triazolo[1,5-a]pyrimidin-5-yl)ethanone 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 6-[2-((2R)-2-methyl-pyrrolidin-1-yl)-ethyl]-2-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl-quinoline
  参考文献：
  名称：

  In vitro studies on a class of quinoline containing histamine H3 antagonists

  摘要：

  A series of quinoline containing histamine H-3 antagonists is reported herein. These analogs were synthesized via the Friedlander quinoline synthesis between an aminoaldehyde intermediate and a methyl ketone allowing for a wide diversity of substituents at the 2-position of the quinoline ring. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.045

文献信息

• Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands
  申请人：Altenbach J. Robert

  公开号：US20050272736A1

  公开（公告）日：2005-12-08

  Compounds of formula (I) wherein R 1 or R 2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , R 5 , L, X, X′, Y, Y′, Z, and Z′ are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

  式（I）中R1或R2为含有至少两个杂原子的三环或二环环，其中R1、R2、R3、R3a、R3b、R4、R5、L、X、X′、Y、Y′、Z和Z′如本文所定义，在预防或改善组织胺-3受体配体引起的病症或紊乱方面具有治疗作用。还公开了包含组织胺-3受体配体的药物组合物，使用这类化合物和组合物的方法，以及制备符合式（I）范围内化合物的过程。
• Tri-and bi-cyclic heteroaryl histamine-3 receptor ligands
  申请人：Altenbach J. Robert

  公开号：US20050256309A1

  公开（公告）日：2005-11-17

  Compounds of formula (I) wherein R 1 or R 2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R 1 , R 2 , R 3 , R 3a , R 3b , R 4 , R 5 , L, X, X′, Y, Y′, Z, and Z′ are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).

  式（I）中R1或R2为含有至少两个杂原子的三环或二环环，其中R1、R2、R3、R3a、R3b、R4、R5、L、X、X′、Y、Y′、Z和Z′如本文所定义，在预防或改善组织胺-3受体配体引起的病症或紊乱方面具有治疗作用。还公开了包含组织胺-3受体配体的药物组合物，使用这类化合物和组合物的方法，以及制备符合式（I）范围内化合物的方法。
• TRI- AND BI-CYCLIC HETEROARYL HISTAMINE-3 RECEPTOR LIGANDS
  申请人：ABBOTT LABORATORIES

  公开号：EP1751130A2

  公开（公告）日：2007-02-14
• US7205316B2
  申请人：——

  公开号：US7205316B2

  公开（公告）日：2007-04-17
• [EN] TRI- AND BI-CYCLIC HETEROARYL HISTAMINE-3 RECEPTOR LIGANDS<br/>[FR] LIGANDS RÉCEPTEURS HISTAMINE-3 HETEROARYL TRI- ET BICYCLIQUE
  申请人：ABBOTT LAB

  公开号：WO2005113536A2

  公开（公告）日：2005-12-01

  Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X', Y, Y', Z, and Z' are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).