α-Methyl-propyl-benzeneethanol | 54518-11-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-Methyl-propyl-benzeneethanol
• 英文别名: 2-methyl-1-phenylpentan-2-ol；(+/-)-2-hydroxy-2-methyl-1-phenyl-pentane；(+/-)-2-Hydroxy-2-methyl-1-phenyl-pentan；2-Methyl-1-phenyl-2-pentanol
• CAS: 54518-11-5
• 化学式: C₁₂H₁₈O
• 分子量: 178.274
• InChiKey: MJHGBEOFMCDYKW-UHFFFAOYSA-N

物化性质

• 沸点：
  210.8±8.0 °C(Predicted)
• 密度：
  0.952±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2906299090

反应信息

• 作为反应物：
  描述：

  α-Methyl-propyl-benzeneethanol 在 硫酸 、 溶剂黄146 、 硫脲 作用下， 以 乙醇 为溶剂， 反应 21.0h， 生成 2-methyl-1-phenylpentan-2-amine
  参考文献：
  名称：

  Catalytic C–H Activation of Phenylethylamines or Benzylamines and Their Annulation with Allenes

  摘要：

  Tetrahydro-3-benzazepines and tetrahydroiso-quinolines are synthesized in one,step from allenes and phenylethylamines or benzylamines,Mechanitically, it is assumed that activation of an aromatic ring with Pd(II) occurs, directed by the primary amine, leading to the formation of a palladacycltinto which'ari, allene then undergoes insertion. The resulting, pi-allyl intermediate cyclizes to the products by aniptramolecular allylic alkylation. The process is particularly useful with 2,3-butadienoates and amines having a quaternary carbon at the alpha-position.

  DOI：

  10.1021/jo501658s
• 作为产物：
  描述：

  d,l-1-苯基-2-甲基-4-戊烯-2-醇 在 platinum on activated charcoal 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 反应 1.0h， 以0.416 g的产率得到α-Methyl-propyl-benzeneethanol
  参考文献：
  名称：

  Catalytic C–H Activation of Phenylethylamines or Benzylamines and Their Annulation with Allenes

  摘要：

  Tetrahydro-3-benzazepines and tetrahydroiso-quinolines are synthesized in one,step from allenes and phenylethylamines or benzylamines,Mechanitically, it is assumed that activation of an aromatic ring with Pd(II) occurs, directed by the primary amine, leading to the formation of a palladacycltinto which'ari, allene then undergoes insertion. The resulting, pi-allyl intermediate cyclizes to the products by aniptramolecular allylic alkylation. The process is particularly useful with 2,3-butadienoates and amines having a quaternary carbon at the alpha-position.

  DOI：

  10.1021/jo501658s

文献信息

• Synergistic Relay Reactions To Achieve Redox‐Neutral α‐Alkylations of Olefinic Alcohols with Ruthenium(II) Catalysis
  作者：Chen‐Chen Li、Jian Kan、Zihang Qiu、Jianbin Li、Leiyang Lv、Chao‐Jun Li

  DOI：10.1002/anie.201915218

  日期：2020.3.9

  the first Grignard-type nucleophilic addition using olefinic alcohols as latent carbonyl groups, providing a higher yield of the corresponding secondary alcohol than the classical hydrazone addition to aldehydes does. A broad scope of unsaturated alcohols and hydrazones, including some complex structures, can be successfully employed in this reaction, which shows the versatility of this approach and

  本文中，我们报告了基于不饱和醇的钌催化氧化还原中性α-烷基化，其基于涉及烯烃异构化（链走）和and酚的协同中继过程，该过程利用了两个效率很低的单独反应步骤之间的相互作用实现高效的整体流程。这种转化显示了-型“碳负离子”和活性质子在一锅反应中的相容性，并且同时使用烯烃醇作为潜在的羰基实现了首次格氏式亲核加成，从而提供了更高产率的相应仲醇比传统的除醛还要多。广泛的不饱和醇和，包括一些复杂的结构，可以成功地用于该反应，
• Iron-Catalyzed Nucleophilic Addition Reaction of Organic Carbanion Equivalents via Hydrazones
  作者：Chen-Chen Li、Xi-Jie Dai、Haining Wang、Dianhu Zhu、Jian Gao、Chao-Jun Li

  DOI：10.1021/acs.orglett.8b01391

  日期：2018.7.6

  Earth-abundant and well-defined iron complexes are found to be cheap and effective catalysts for a series of “umpolung” nucleophilic additions of hydrazones. The new catalytic system not only maintains the broad substrate scope of an earlier expensive ruthenium system but also attains chemoselectivity of different kinds of carbonyl groups. Furthermore, the iron catalyst enables this reaction at ambient

  发现富含地球的铁和定义明确的铁络合物对于一系列“ ”亲核加成be而言，是廉价且有效的催化剂。新的催化系统不仅保持了较早的昂贵钌系统的广泛底物范围，而且还获得了不同种类羰基的化学选择性。此外，铁催化剂能够在环境温度下进行该反应。
• PROCESS FOR PREPARING 4-CYCLOHEXYL-2-METHYL-2-BUTANOL
  申请人：Ebel Klaus

  公开号：US20130245132A1

  公开（公告）日：2013-09-19

  Process for preparing 4-cyclohexyl-2-methyl-2-butanol The present invention relates to a process for preparing 4-cyclohexyl-2-methyl-2-butanol. The process comprises the following steps: a) reaction of styrene with isopropanol at elevated temperature to obtain 4-phenyl-2-methyl-2-butanol, and b) heterogeneously catalyzed hydrogenation of 4-phenyl-2-methyl-2-butanol over a catalyst suitable for ring hydrogenation of aromatics.

  制备4-环己基-2-甲基-2-丁醇的过程本发明涉及一种制备4-环己基-2-甲基-2-丁醇的过程。该过程包括以下步骤：a）在高温下将苯乙烯与异丙醇反应，得到4-苯基-2-甲基-2-丁醇；b）在适合进行芳香环加氢的催化剂上对4-苯基-2-甲基-2-丁醇进行非均相催化加氢。
• Levy; Tabart, Bulletin de la Societe Chimique de France, 1931, vol. <4> 49, p. 1782,1786
  作者：Levy、Tabart

  DOI：——

  日期：——
• Ratschinskii; Winokurowa, Zhurnal Obshchei Khimii, 1954, vol. 24, p. 272,278
  作者：Ratschinskii、Winokurowa

  DOI：——

  日期：——