S-Methyl-β-N-(diphenylmethylen)dithiocarbazid | 26158-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S-Methyl-β-N-(diphenylmethylen)dithiocarbazid
• 英文别名: S-methyl-β-N-(diphenylmethylene)dithiocarbazate；methyl N-(benzhydrylideneamino)carbamodithioate
• CAS: 26158-46-3
• 化学式: C₁₅H₁₄N₂S₂
• 分子量: 286.422
• InChiKey: HPUMLCZXRRCNIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  81.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  RuH₂(CO)(PPh₃)₃ 、 S-Methyl-β-N-(diphenylmethylen)dithiocarbazid 以 苯 为溶剂， 以70%的产率得到
  参考文献：
  名称：

  Jayakumar, N.; Yogalakshmi, P.; Natarajan, K., Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1990, vol. 20, p. 661 - 672

  摘要：

  DOI：
• 作为产物：
  描述：

  二苯甲酮 、 肼基二硫代甲酸甲酯 在 硫酸 作用下， 以 甲醇 为溶剂， 生成 S-Methyl-β-N-(diphenylmethylen)dithiocarbazid
  参考文献：
  名称：

  Synthesis antimicrobial and anticancer activity of N′-arylmethylidene-piperazine-1-carbothiohydrazide

  摘要：

  Ten newly synthesized thiosemicarbazones of piperazine (3a-3j) were evaluated for their antibacterial and antifungal activity against non-pathogenic strains of Escherichia coli (NCIM 2068), Klebsiella pneumonia (NCIM 2957), Staphylococcus aureus (NCIM 2079), and Bacillus subtilis (NCIM 2921); pathogenic strains of Vibrio cholerae, protease, Candida albicans and Aspergillus niger. All the 10 compounds (3a-3j) were found to be better than Ciprofloxacin against B. subtilis and four molecules (3c, 3d, 3e, and 3h) against S. aureus. Compound 3j, a derivative of benzophenone, has been identified as a potent and promising candidate against C. albicans. The compounds were also evaluated for their anticancer activity against HBL-100 and HL60 cell lines. Compound 3a, a p-hydroxy benzaldehyde derivative, has been identified as a potent and promising candidate.

  DOI：

  10.1007/s00044-012-0279-4

文献信息

• 2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents
  作者：Daniel L. Klayman、Joseph F. Bartosevich、T. Scott Griffin、Carl J. Mason、John P. Scovill

  DOI：10.1021/jm00193a020

  日期：1979.7

  Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety

  基于对2-乙酰基吡啶4-苯基-3-硫代半乳糖苷（1）观察到的抗疟疾特性，制备了一系列相关的硫代半胱氨酸并在小鼠中对柏氏疟原虫进行了测试。筛选结果表明2-吡啶基亚乙基的存在是关键的，并且在硫半脲部分的N 4处的某些苯基，苄基，苯乙基或环烷基也有助于抗疟活性。
• Complexes of technetium(V) with bidentate schiff bases derived from S-methyldithiocarbazate
  作者：J.G.H. Du Preez、T.I.A. Gerber、O. Knoesen

  DOI：10.1016/s0020-1693(00)81749-1

  日期：1987.9

  oxotechnetium(V) complexes with substituted S-methyldithiocarbazate Schiff bases are described. These six-coordinated complexes show a definite correlation between the strength of the TcO bond and the degree of double bond character of the coordinating CN bond. The relative strength of the TcO bond is mainly determined by the electronic influence of the cis-ligands and not by the presence or influence of a

  摘要描述了几种带有取代的S-甲基二硫代咔唑席夫碱的中性氧tech（V）配合物的合成和表征。这六个配位的配合物显示出TcO键的强度与配位的CN键的双键特征程度之间具有明确的相关性。Tc ＝ O键的相对强度主要由顺式配体的电子影响决定，而不是由反式至氧代基团的配体的存在或影响决定。根据元素分析，红外光谱和电子光谱，电导率和磁化率测量对复合物进行了表征。
• Sharan, Ram; Gupta, Gopal; Kapoor, Ramesh Narain, Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1983, vol. 13, p. 1015 - 1028
  作者：Sharan, Ram、Gupta, Gopal、Kapoor, Ramesh Narain

  DOI：——

  日期：——
• Metal chelates of dithiocarbazic acid and its derivatives. IX. Metal chelates of ten new schiff bases derived from S-methyldithiocarbazate
  作者：M. Das、S.E. Livingstone

  DOI：10.1016/s0020-1693(00)91065-x

  日期：1976.1
• Sengupta, S. K.; Kumar, Shyam, Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1982, vol. 12, p. 297 - 308
  作者：Sengupta, S. K.、Kumar, Shyam

  DOI：——

  日期：——