2-mercapto-N-(o-tolyl)acetamide | 36076-50-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-mercapto-N-(o-tolyl)acetamide
• 英文别名: Mercapto-N-o-tolylacetamid；N-(o-Tolyl)mercaptoacetamid；N-(o-Tolyl)-2-mercaptoacetamid；N-(o-tolyl)-2-mercaptoacetamide；mercapto-acetic acid o-toluidide；Mercapto-essigsaeure-o-toluidid；Thioglykolsaeure-o-toluidid；Thioglycolic acid o-toluidide；N-(2-methylphenyl)-2-sulfanylacetamide
• CAS: 36076-50-3
• 化学式: C₉H₁₁NOS
• mdl: MFCD01670853
• 分子量: 181.258
• InChiKey: TVBOSLXNNWWFEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  30.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-mercapto-N-(o-tolyl)acetamide 在 盐酸 、 乙醇 、 三氯化铁 作用下， 生成 2,2’-dithiobis(N-(2-methylphenyl)acetamide)
  参考文献：
  名称：

  Farm Wages and Living Standards in the Industrial Revolution: England,1670–1869

  摘要：

  This article calculates, nationally and by region, real wages for male English farm workers. Rural living costs are also estimated. Only in the 1820s did real day wages begin to increase from their level in the century before the industrial revolution, but by the 1860s they had climbed to 46 per cent above the average for 1670-1769. It is argued that these farm real wage gains will imply equivalent improvements in urban living standards. But, given what we know of land rents and returns on capital, farm wages entail no agricultural productivity gains before 1820, and modest gains thereafter.

  DOI：

  10.1111/1468-0289.00200
• 作为产物：
  描述：

  2-S-(acetylthio)-N-(o-tolyl)acetamide 在 potassium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 0.75h， 以99%的产率得到2-mercapto-N-(o-tolyl)acetamide
  参考文献：
  名称：

  N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa

  摘要：

  同时抑制金属β-内酰胺酶（MBLs）和像拉斯B这样的毒力因子，如来自铜绿假单胞菌的，提供了一种对抗抗生素耐药病原体的新方法。

  DOI：

  10.1039/d1md00187f

文献信息

• Some new organozirconium(IV) compounds with N-(aryl)-2-mercaptoacetamides
  作者：Satish C. Dixit、Ram Sharan、Ramesh N. Kapoor

  DOI：10.1016/0022-328x(87)85132-x

  日期：1987.9

  Reactions of dichlorodicyclopentadienylzirconium(IV) with various stoichiometric proportions of mercaptoacetamides have been examined. Complexes of the type Cp2Zr(MA)Cl and Cp2Zr(MA)2 (Cp  Cyclopentadienyl and MAH  N-(aryl)-2-mercaptoacetamide; aryl  phenyl, o-tolyl, m-tolyl, p-tolyl, α-naphthyl or 3,5-dimethylphenyl) were obtained, and were characterized by elemental analysis and by 1H NMR, variable

  已经研究了二氯二环戊二烯基锆（IV）与各种化学计量比例的巯基乙酰胺的反应。该类型的复合物的Cp 2 Zr的（MA）Cl和的Cp 2 Zr的（MA）2（CP环戊二烯基和MAH ñ - （芳基）-2-巯基乙酰胺;芳基苯基，ö甲苯基，米间-甲苯基，p -得到甲苯基，α-萘基或3,5-二甲基苯基），并通过元素分析和1 H NMR，可变温度1 H NMR，IR和电子光谱数据进行表征。
• NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
  申请人：Girardet Jean-Luc

  公开号：US20080249131A1

  公开（公告）日：2008-10-09

  Various carbonyl amides are employed in vitro and in vivo as non-nucleoside inhibitors of a reverse transcriptase, and particularly of HIV reverse transcriptase. Therefore, contemplated compounds may be employed in the treatment of HIV infected patients. Further contemplated aspects include pharmaceutical compositions comprising therapeutically effective amounts of contemplated compounds.

  各种羰基酰胺在体外和体内被用作反转录酶的非核苷类抑制剂，尤其是HIV反转录酶的抑制剂。因此，考虑到的化合物可以用于治疗HIV感染患者。进一步考虑的方面包括包含考虑化合物的治疗有效量的制药组合物。
• 5-(benz-(z)-ylidene)-thiazolidin-4-one derivatives as immunosuppressant agents
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2295418A1

  公开（公告）日：2011-03-16

  The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4- one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

  本发明涉及含有至少一种噻唑烷-4-酮衍生物的药物组合物，用于预防或治疗与活化免疫系统相关的疾病。此外，本发明还涉及新型噻唑烷-4-酮衍生物，特别是用作药物活性化合物。所述化合物尤其还可用作免疫抑制剂。
• Non-nucleoside reverse transcriptase inhibitors
  申请人：Ardea Biosciences, Inc.

  公开号：EP2353593A1

  公开（公告）日：2011-08-10

  Various carbonyl amides are employed in vitro and in vivo as non-nucleoside inhibitors of a reverse transcriptase, and particularly of HIV reverse transcriptase. Therefore, contemplated compounds may be employed in the treatment of HIV infected patients. Further contemplated aspects include pharmaceutical compositions comprising therapeutically effective amounts of contemplated compounds.

  各种羰基酰胺在体外和体内被用作逆转录酶，特别是 HIV 逆转录酶的非核苷抑制剂。因此，预期化合物可用于治疗艾滋病毒感染患者。进一步考虑的方面包括包含治疗有效量的预期化合物的药物组合物。
• Singh, Y.; Sharan, R.; Kapoor, R. N., Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1986, vol. 16, p. 1225 - 1236
  作者：Singh, Y.、Sharan, R.、Kapoor, R. N.

  DOI：——

  日期：——