2,3,4-trifluorothiophene | 396100-64-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 2,3,4-trifluorothiophene
• 英文别名: trifluorothiophene
• CAS: 396100-64-4
• 化学式: C₄HF₃S
• 分子量: 138.113
• InChiKey: NVYGAQHFLTUGFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2,3,3-tetrafluorobutane-1,4-diyl bis(4-methylbenzenesulfonate) 在 sodiumsulfide nonahydrate 、 Selectfluor 、 potassium hydroxide 作用下， 以 N,N-二甲基乙酰胺 、 环丁砜 、 二甲基亚砜 为溶剂， 反应 11.25h， 生成 3,3,4,4-四氟四氢呋喃 、 2,3,4-trifluorothiophene
  参考文献：
  名称：

  Tetrafluorothiophene S,S-Dioxide: A Perfluorinated Building Block

  摘要：

  Tetrafluorothiophene S,S-dioxide, a highly reactive diene and dienophile, has been synthesized. A new route to 3,4-difluoro- and tetrafluorothiophene has been realized, and the previously unknown 2,3,4-trifluorothiophene has been obtained. The reactivity of tetrafluorothiophene S-oxide has been compared with that of the S,S-dioxide.

  DOI：

  10.1021/jo402373x

文献信息

• Tetrafluorothiophene <i>S</i>,<i>S</i>-Dioxide: A Perfluorinated Building Block
  作者：David M. Lemal、Marc Akashi、Yan Lou、Vivek Kumar

  DOI：10.1021/jo402373x

  日期：2013.12.20

  Tetrafluorothiophene S,S-dioxide, a highly reactive diene and dienophile, has been synthesized. A new route to 3,4-difluoro- and tetrafluorothiophene has been realized, and the previously unknown 2,3,4-trifluorothiophene has been obtained. The reactivity of tetrafluorothiophene S-oxide has been compared with that of the S,S-dioxide.