(Z)-7-[((E)-4-Hydroxy-non-2-enyl)-methanesulfonyl-amino]-hept-5-enoic acid | 63857-32-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z)-7-[((E)-4-Hydroxy-non-2-enyl)-methanesulfonyl-amino]-hept-5-enoic acid
• 英文别名: (Z)-7-[[(E)-4-hydroxynon-2-enyl]-methylsulfonylamino]hept-5-enoic acid
• CAS: 63857-32-9
• 化学式: C₁₇H₃₁NO₅S
• 分子量: 361.503
• InChiKey: NWTKHPNFGAQNLK-QTJHGLNVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  ethyl 7-bromo-5-heptynoate 生成 (Z)-7-[((E)-4-Hydroxy-non-2-enyl)-methanesulfonyl-amino]-hept-5-enoic acid
  参考文献：
  名称：

  11,12-Secoprostaglandins. 4. 7-(N-Alkylmethanesulfonamido)heptanoic acids

  摘要：

  A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.

  DOI：

  10.1021/jm00220a014

文献信息

• 11,12-Secoprostaglandins. 4. 7-(N-Alkylmethanesulfonamido)heptanoic acids
  作者：James H. Jones、Wilbur J. Holtz、John B. Bicking、Edward J. Cragoe、Lewis R. Mandel、Frederick A. Kuehl

  DOI：10.1021/jm00220a014

  日期：1977.10

  A series of 7-(N-alkylmethanesulfonamido) heptanoic acids has been prepared which represents an extension of our 8-aza-11,12-secoprostaglandin studies. The studies. The compounds mimic the natural prostaglandins in that they markedly stimulate cAMP formation in the mouse ovary assay.