methyl 2-pivalamidoisonicotinate | 1235666-16-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: methyl 2-pivalamidoisonicotinate
• 英文别名: 2-(2,2-Dimethyl-propionylamino)-isonicotinic acid methyl ester；methyl 2-(2,2-dimethylpropanoylamino)pyridine-4-carboxylate
• CAS: 1235666-16-6
• 化学式: C₁₂H₁₆N₂O₃
• 分子量: 236.271
• InChiKey: VIINVAGIQKVNOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  68.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  t-butoxide 、 methyl 2-pivalamidoisonicotinate 、 乙腈 在 钾 、 甲苯 、 乙醚 作用下， 以 甲苯 为溶剂， 反应 19.0h， 以to obtain N-[4-(2-cyano-acetyl)-pyridin-2-yl]-2,2-dimethyl-propionamide as a yellow solid (0.9 g, 94.7%)的产率得到N-[4-(2-cyano-acetyl)-pyridin-2-yl]-2,2-dimethyl-propionamide
  参考文献：
  名称：

  Pyrazolo[1,5-A]pyrimidine derivatives and methods of use thereof

  摘要：

  本发明涉及吡唑并[1,5-a]嘧啶衍生物，包括有效量的吡唑并[1,5-a]嘧啶衍生物的组合物以及治疗或预防癌症的方法，包括向需要的受试者施用有效量的吡唑并[1,5-a]嘧啶衍生物。

  公开号：

  US20070219186A1
• 作为产物：
  描述：

  2-amino-isonicotinic acid methyl ester hydrochloride 、 三甲基乙酰氯 、 生成 methyl 2-pivalamidoisonicotinate
  参考文献：
  名称：

  ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS

  摘要：

  本发明涉及一种芳基酰胺衍生物，其具有阻断电压门控钠通道（如TTX-S通道）的活性，并且在涉及电压门控钠通道的疾病和疾病的治疗或预防中有用。本发明还涉及包含这些化合物的制药组合物以及这些化合物和组合物在涉及电压门控钠通道的这种疾病的预防或治疗中的使用。

  公开号：

  US20140336377A1

文献信息

• [EN] AMIDE DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS<br/>[FR] DÉRIVÉS D'AMIDE UTILISÉS EN TANT QUE BLOQUEURS DE NAV1,7 ET DE NAV1,8
  申请人：RAQUALIA PHARMA INC

  公开号：WO2018235851A1

  公开（公告）日：2018-12-27

  The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及酰胺衍生物，具有对Nav1.7和Nav1.8通道的阻塞活性，并且在涉及电压门控钠通道的疾病和疾病的治疗或预防中有用。该发明还涉及包含这些化合物的药物组合物，以及在涉及电压门控钠通道的疾病的预防或治疗中使用这些化合物和组合物。
• [EN] HETEROCYCLIC DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS<br/>[FR] DÉRIVÉS HÉTÉROCYLCIQUES UTILISÉS EN TANT QUE BLOQUEURS NAV1.7 ET NAV1.8
  申请人：RAQUALIA PHARMA INC

  公开号：WO2020138271A1

  公开（公告）日：2020-07-02

  The present invention relates to heterocyclic derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及具有阻断活性的杂环衍生物，其作用于Nav1.7和Nav1.8通道的电压门控钠通道，并且在处理或预防涉及电压门控钠通道的疾病和疾病方面具有用途。该发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的疾病方面的用途。
• [EN] ARYLAMIDE DERIVATIVES AS TTX-S BLOCKERS<br/>[FR] DÉRIVÉS D'ARYLAMIDE EN TANT QU'AGENTS BLOQUANTS DE TTX-S
  申请人：RAQUALIA PHARMA INC

  公开号：WO2012053186A1

  公开（公告）日：2012-04-26

  The present invention relates to arylamide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及具有对电压门控钠通道（如TTX-S通道）具有阻塞活性的芳基酰胺衍生物，用于治疗或预防涉及电压门控钠通道的疾病和疾病。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及电压门控钠通道的这类疾病中使用这些化合物和组合物。
• Arylamide derivatives as TTX-S blockers
  申请人：Yamagishi Tatsuya

  公开号：US09302991B2

  公开（公告）日：2016-04-05

  The present invention relates to arylamide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及芳基酰胺衍生物，其具有阻断电压门控钠通道（TTX-S通道）的活性，并且在治疗或预防涉及电压门控钠通道的疾病和疾病方面有用。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及电压门控钠通道的疾病方面使用这些化合物和组合物。
• Amide derivatives as Nav1.7 and Nav1.8 blockers
  申请人：RaQualia Pharma Inc.

  公开号：US11154544B2

  公开（公告）日：2021-10-26

  The present invention relates to amide derivatives which have blocking activities of voltage gated sodium channels as the Nav1.7 and Nav1.8 channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及对电压门控钠通道（如 Nav1.7 和 Nav1.8 通道）具有阻断活性的酰胺衍生物，它们可用于治疗或预防涉及电压门控钠通道的紊乱和疾病。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在预防或治疗涉及电压门控钠通道的此类疾病中的用途。