N-[1-[2-[1-(2-aminoethyl)cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide | 518284-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[1-[2-[1-(2-aminoethyl)cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide
• 英文别名: N-[1-[2-[1-(2-aminoethyl)cyclohexyl]ethyl]piperidin-4-yl]-N-(4-methylphenyl)furan-2-carboxamide
• CAS: 518284-28-1
• 化学式: C₂₇H₃₉N₃O₂
• 分子量: 437.626
• InChiKey: ZYNQDRDOVFAHLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  62.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-吡啶甲醛 、 N-[1-[2-[1-(2-aminoethyl)cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide 在 三乙酰氧基硼氢化钠 、 溶剂黄146 、 碳酸氢钠 作用下， 以 1,2-二氯乙烷 、 水 为溶剂， 反应 18.0h， 以96%的产率得到N-[1-[2-[1-[2-[bis(pyridin-3-ylmethyl)amino]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide
  参考文献：
  名称：

  EP1621538

  摘要：

  公开号：
• 作为产物：
  描述：

  tert-butyl 2-[1-[2-[4-[N-(p-tolyl)-2-furancarboxamido]piperidin-1-yl]ethyl]cyclohexyl]ethylcarbamate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 生成 N-[1-[2-[1-(2-aminoethyl)cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide
  参考文献：
  名称：

  NOVEL 4-(2FUROYL)AMINOPIPERIDINES, INTERMEDIATES IN SYNTHESIZING THE SAME, PROCESS FOR PRODUCING THE SAME AND MEDICINAL USE OF THE SAME

  摘要：

  公开号：

  EP1443046B1

文献信息

• Novel 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
  申请人：Fukutomi Ryuuta

  公开号：US20050085508A1

  公开（公告）日：2005-04-21

  There are provided novel 4-(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is CH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH 2 or NH; W is O or S; T is O or N—R 15 wherein R 15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R 1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxycarbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

  提供了一种新的4-(2-呋喃酰基)氨基哌啶化合物，其通式表示为(I)，以及它们的合成中间体、制备过程和含有它们的药物。 在上述式中，X为CH或N，Y为以下通式(II)、式(II-a)或式(III)的基团： 其中a、b和c均为0-6的整数；Z为CH2或NH；W为O或S；T为O或N—R15，其中R15为H、C1-C6烷基、苄基或苯乙基；R1为H、C1-C6烷氧羰基、苄氧羰基或类似基团。本发明所述的4-(2-呋喃酰基)氨基哌啶衍生物具有阿片μ受体拮抗活性，可用于治疗或预防由μ受体激动剂引起的副作用，包括便秘、恶心/呕吐或瘙痒，或用于治疗或预防特发性便秘、术后肠梗阻、麻痹性肠梗阻、肠易激综合征或慢性瘙痒。
• Novel 4-(2-furoyl) aminopiperidienes, intermediates for synthesizing the same, processes for preparing the same and medicinal use of the same
  申请人：Fukutomi Ryuuta

  公开号：US20080194826A1

  公开（公告）日：2008-08-14

  A compound represented the general formula (V): wherein X is CH or N; and Y a is a group of the general formula selected from:

  一个化合物的一般式表示为(V)：其中X是CH或N; 而Y是从一般式中选择的一个基团：
• 4-(2-Furoyl) aminopiperidine compound useful as therapeutic agent for itching
  申请人：Muraki Yukiko

  公开号：US20060270632A1

  公开（公告）日：2006-11-30

  There are provided compounds represented by the following general formula (I): [where R 1 is 5-methylpyridin-2-yl, p-tolyl or mesityl, R 2 is one of the following general formulas (II)-(IX): (where R 3 is C1-C4 alkyl, R 4 is H or C1-C4 alkyl, R 5 is H, 3-pyridylmethyl or 4-pyridylmethyl, and R 6 is 2,4-dihydroxybenzyl, 3-pyridylmethyl or 4-pyridylmethyl), or when R 1 is mesityl, R 2 is the following formula (X)], and pharmaceutically acceptable salts thereof. The compounds exhibit pruritus-inhibiting action, and are useful for prevention or treatment of itching and pruritus caused by reaction against insect-inflicted wounds, reaction against environmental allergens, skin infections or external parasite infections, or caused to renal dialysis patient.

  提供了以下通式（I）所代表的化合物：[其中R1为5-甲基吡啶-2-基、对甲基苯基或二甲基苯基，R2为以下通式（II）-（IX）之一：（其中R3为C1-C4烷基，R4为H或C1-C4烷基，R5为H、3-吡啶甲基或4-吡啶甲基，R6为2,4-二羟基苯甲基、3-吡啶甲基或4-吡啶甲基），或当R1为二甲基苯基时，R2为以下通式（X）]，以及其药学上可接受的盐。这些化合物具有抑制瘙痒作用，可用于预防或治疗由对昆虫造成的伤口反应、对环境过敏原的反应、皮肤感染或外部寄生虫感染引起的瘙痒和瘙痒，或透析患者引起的瘙痒。
• 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
  申请人：Kyorin Pharmaceutical Co., Ltd.

  公开号：US07375115B2

  公开（公告）日：2008-05-20

  There are provided novel 4(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is OH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III): wherein a, b and c are each an integer of 0-6; Z is CH2 or NH; W is O or S; T is O or N—R15 wherein R15 is H, a C1-C6 alkyl group, a benzyl group or a phenethyl group; and R1 is H, a C1-C6 alkoxycarbonyl group, a benzyloxy-carbonyl group, or the like. The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid μ antagonistic activity and are useful for the treatment or prevention of side effects which are caused by μ receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

  提供了一种新型的4（2-呋喃基）氨基哌啶，其通式为（I），以及它们的合成中间体、制备方法和含有它们的药物。在上述公式中，X为OH或N，而Y为以下通式（II）、公式（II-a）或公式（III）的一种：其中a、b和c均为0-6的整数；Z为CH2或NH；W为O或S；T为O或N-R15，其中R15为H、C1-C6烷基、苄基或苯乙基；而R1为H、C1-C6烷氧羰基、苄氧羰基或类似物。根据本发明的4-(2-呋喃基)氨基哌啶衍生物具有阿片μ拮抗活性，并可用于治疗或预防由μ受体激动剂引起的副作用，包括便秘、恶心/呕吐或瘙痒，或用于治疗或预防特发性便秘、术后肠梗阻、麻痹性肠梗阻、肠易激综合征或慢性瘙痒。
• 4-(2-furoyl)aminopiperidine compound useful as therapeutic agent for itching
  申请人：Kyorin Pharmaceutical Co., Ltd

  公开号：US07601843B2

  公开（公告）日：2009-10-13

  There are provided compounds represented by the following general formula (I): [where R1 is 5-methylpyridin-2-yl, p-tolyl or mesityl, R2 is one of the following general formulas (II)-(IX): (where R3 is C1-C4 alkyl, R4 is H or C1-C4 alkyl, R5 is H, 3-pyridylmethyl or 4-pyridylmethyl, and R6 is 2,4-dihydroxybenzyl, 3-pyridylmethyl or 4-pyridylmethyl), or when R1 is mesityl, R2 is the following formula (X)], and pharmaceutically acceptable salts thereof. The compounds exhibit pruritus-inhibiting action, and are useful for prevention or of itching and pruritus caused by reaction against insect-inflicted wounds, reaction against environmental allergens, skin infections or external parasite infections, or caused to renal dialysis patient.

  以下是通用式（I）所代表的化合物：[其中R1是5-甲基吡啶-2-基，对甲基苯基或三甲基苯基，R2是以下通用式（II）-（IX）之一：（其中R3是C1-C4烷基，R4是H或C1-C4烷基，R5是H，3-吡啶甲基或4-吡啶甲基，R6是2,4-二羟基苯甲基，3-吡啶甲基或4-吡啶甲基），或当R1是三甲基苯基时，R2是以下式子（X）]，以及其药学上可接受的盐。这些化合物具有止痒作用，可用于预防或治疗由昆虫叮咬引起的瘙痒和瘙痒反应，环境过敏原引起的反应，皮肤感染或外部寄生虫感染引起的瘙痒，或透析患者引起的瘙痒。